TITLE

Evidence of Cross-Reactive Immunity to 2009 Pandemic Influenza A Virus in Workers Seropositive to Swine H1N1 Influenza Viruses Circulating in Italy

AUTHOR(S)
De Marco, Maria A.; Porru, Stefano; Cordioli, Paolo; Cesana, Bruno M.; Moreno, Ana; Calzoletti, Laura; Bonfanti, Lebana; Boni, Arianna; Di Carlo, Antonio Scotto; Arici, Cecilia; Carta, Angela; Castrucci, Maria R.; Donatelli, Isabella; Tomao, Paola; Peri, Vittoria M.; Di Trani, Livia; Vonesch, Nicoletta
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Pigs play a key epidemiologic role in the ecology of influenza A viruses (IAVs) emerging from animal hosts and transmitted to humans. Between 2008 and 2010, we investigated the health risk of occupational exposure to swine influenza viruses (SIVs) in Italy, during the emergence and spread of the 2009 H1N1 pandemic (H1N1pdm) virus. Methodology/Principal Findings: Serum samples from 123 swine workers (SWs) and 379 control subjects (Cs), not exposed to pig herds, were tested by haemagglutination inhibition (HI) assay against selected SIVs belonging to H1N1 (swH1N1), H1N2 (swH1N2) and H3N2 (swH3N2) subtypes circulating in the study area. Potential cross-reactivity between swine and human IAVs was evaluated by testing sera against recent, pandemic and seasonal, human influenza viruses (H1N1 and H3N2 antigenic subtypes). Samples tested against swH1N1 and H1N1pdm viruses were categorized into sera collected before (n. 84 SWs; n. 234 Cs) and after (n. 39 SWs; n. 145 Cs) the pandemic peak. HI-antibody titers ≥10 were considered positive. In both pre-pandemic and post-pandemic peak subperiods, SWs showed significantly higher swH1N1 seroprevalences when compared with Cs (52.4% vs. 4.7% and 59% vs. 9.7%, respectively). Comparable HI results were obtained against H1N1pdm antigen (58.3% vs. 7.7% and 59% vs. 31.7%, respectively). No differences were found between HI seroreactivity detected in SWs and Cs against swH1N2 (33.3% vs. 40.4%) and swH3N2 (51.2 vs. 55.4%) viruses. These findings indicate the occurrence of swH1N1 transmission from pigs to Italian SWs. Conclusion/Significance: A significant increase of H1N1pdm seroprevalences occurred in the post-pandemic peak subperiod in the Cs (p<0.001) whereas SWs showed no differences between the two subperiods, suggesting a possible occurrence of cross-protective immunity related to previous swH1N1 infections. These data underline the importance of risk assessment and occupational health surveillance activities aimed at early detection and control of SIVs with pandemic potential in humans.
ACCESSION #
87625547

 

Related Articles

  • Can Your Dog Make You Sick? WARGO, MEREDITH // Dog World;Jul2010, Vol. 95 Issue 7, p34 

    The article presents information on zoonotic diseases, diseases that are transmitted from animals to humans. According to the World Health Organization (WHO), the diseases are transmitted by parasites, bacteria, viruses and fungi. It references a study which identified the three different...

  • Elephant borne disease: An important concern. Err, Hai; Wiwanitkit, Viroj // Annals of Tropical Medicine & Public Health;Jan/Feb2014, Vol. 7 Issue 1, p78 

    The article discusses issues related to diseases that can be transmitted from pet elephants to human beings is presented.

  • Optimizing Vaccine Allocation at Different Points in Time during an Epidemic. Matrajt, Laura; Longini Jr., Ira M. // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Background: Pandemic influenza A(H1N1) 2009 began spreading around the globe in April of 2009 and vaccination started in October of 2009. In most countries, by the time vaccination started, the second wave of pandemic H1N1 2009 was already under way. With limited supplies of vaccine, we are left...

  • Influenza (H1N1) 2009 Epidemic in Saint Petersburg. Yakovlev, A. A.; Parkov, O. V.; Musatov, V. B.; Fedunyak, I. P.; Firsov, S. L.; Karnaukhov, E. V. // EpiNorth Journal;Sep2010, Vol. 11 Issue 3, p75 

    The article discusses the influenza A(H1N1) epidemic in Saint Petersburg, Russia in 2009. It says that the unpredictable transmission and incidence of the disease in areas with similar social, economic and environmental conditions should be the main concern. It mentions the need to develop...

  • Drug chains prepare for a busy flu season.  // Chain Drug Review;9/14/2009, Vol. 31 Issue 15, p1 

    The article reports on the plan of drugstores in the U.S. in preparation for the flu season and to lessen the spread of the H1N1 swine flu. They plan to begin administering flu shots in stores and through clinics. These actions will be implemented earlier than usual to meet the demand for both...

  • Swine flu vaccination: are we ready? Bishop, Tina // Practice Nurse;8/14/2009, Vol. 38 Issue 3, p5 

    The article describes the expected availability of swine flu vaccines in Great Britain and the foreseeable problems with administering a vaccination program. The author speculates about who will provide the swine flu vaccine and where it will be dispensed. She also believes that questions about...

  • Show Pig Group Sets Guidelines. Vansickle, Joe // National Hog Farmer;6/15/2009, Vol. 54 Issue 6, p15 

    The article features the biosecurity guidelines developed by the Show Pig Working Group to mitigate the effects of the H1N1 Influenza A virus outbreak in the U.S. It emphasizes the application of good biosecurity measures to reduce the chance of tracking the virus back to the farm or exposing...

  • HOW THINGS WORK.  // Business Today;4/29/2012, Vol. 21 Issue 9, p32 

    The article offers information on swine flu caused by H1N1 virus that spreads in humans from pigs and mentions that Indian states Pune and Maharashtra are worstly hit.

  • Free H1N1 flu shots.  // Lakelander (Whitney, TX);1/13/2010, Vol. 24 Issue 2, p1 

    The article announces that a series of free H1N1 immunization clinics will be held by the Texas Department of State Health Services Region 7 in January 2010 in Waco.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics