Increased Gastric IL-1β Concentration and Iron Deficiency Parameters in H. pylori Infected Children

Queiroz, Dulciene Maria Magalhaes; Rocha, Andreia Maria Camargos; Melo, Fabricio Freire; Rocha, Gifone Aguiar; Teixeira, Kádima Nayara; Carvalho, Simone Diniz; Bittencourt, Paulo Fernando Souto; Castro, Lucia Porto Fonseca; Crabtree, Jean E.
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Association between H. pylori infection, iron deficiency and iron deficiency anaemia has been described, but the mechanisms involved have not been established. We hypothesized that in H. pylori infected children increased gastric concentrations of IL-1β and/or TNF-α, both potent inhibitors of gastric acid secretion that is essential for iron absorption, are predictors for low blood concentrations of ferritin and haemoglobin, markers of early depletion of iron stores and anaemia, respectively. We evaluated 125 children undergoing endoscopy to clarify the origin of gastrointestinal symptoms. Gastric specimens were obtained for H. pylori status and cytokine evaluation and blood samples for determination of iron deficiency/iron deficiency anaemia parameters and IL1 cluster and TNFA polymorphisms that are associated with increased cytokine secretions. Higher IL-1β and TNF-α gastric concentrations were observed in H. pylori-positive (n = 47) than in -negative (n = 78) children. Multiple linear regression models revealed gastric IL-1β, but not TNF-α, as a significant predictor of low ferritin and haemoglobin concentrations; results were reproduced in young children in whom IL1RN polymorphic genotypes associated with higher gastric IL-1β expression and lower blood ferritin and haemoglobin concentrations. In conclusion, high gastric levels of IL-1β can be the link between H. pylori infection and iron deficiency/iron deficiency anaemia in childhood.


Related Articles

  • Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population. Melo Barbosa, Hivana Patricia; Martins, Luisa Caricio; Batista dos Santos, Sidney Emanuel; Demachki, Samia; Assumpção, Mônica Baraúna; Aragão, Charliana Damasceno; de Oliveira Corvelo, Tereza Cristina; Wagner, Siegfried // World Journal of Gastroenterology;3/28/2009, Vol. 15 Issue 12, p1465 

    AIM: To study the association between Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-α polymorphisms, infection by Helicobacter pylori ( H pylori) and the development of gastrointestinal diseases. METHODS: Genomic DNA was extracted from the peripheral blood of 177 patients with various...

  • Interleukin-1β genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection. Take, Susumu; Mizuno, Motowo; Ishiki, Kuniharu; Nagahara, Yasuhiro; Yoshida, Tomowo; Inaba, Tomoki; Yamamoto, Kazuhide; Okada, Hiroyuki; Yokota, Kenji; Oguma, Keiji; Shiratori, Yasushi // American Journal of Gastroenterology;Nov2003, Vol. 98 Issue 11, p2403 

    : ObjectivesGenetic polymorphism of interleukin (IL)–1β is associated with differences in gastric acid suppression in response to Helicobacter pylori (H. pylori) infection. Thus, the polymorphism might affect H. pylori eradication therapy, as antibiotics used in treatment regimens may...

  • Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors. Mejías-Luque, R.; Lindén, S. K.; Garrido, M.; Tye, H.; Najdovska, M.; Jenkins, B. J.; Iglesias, M.; Ernst, M.; de Bolós, C. // Oncogene;3/25/2010, Vol. 29 Issue 12, p1753 

    Infection of gastric mucosa by Helicobacter pylori induces an inflammatory response with increased levels of proinflammatory cytokines. Among them, tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 induce the activation of signaling pathways that regulate genes expression, such...

  • Importance of Sideropenic Anemia in the Diagnosis of Gastrointestinal Tract Tumors. Sahovic, Sanela; Vukobrat-Bijedic, Zora; Sahovic, Vahidin // Materia Socio Medica;Jun2012, Vol. 24 Issue 2, p81 

    Introduction: Sideropenic anemia is a hypochromic, microcytic anemia caused by insufficient iron level in the body. This is the most common anemia. In a large percentage it is the symptom of gastrointestinal tract cancer. Anemia was defined by hemoglobin level <119 g/dl, hematocrit <0.356 for...

  • Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Huang, Xiaolu // Postgraduate Medical Journal;May2010, Vol. 86 Issue 1015, p272 

    BACKGROUND: Recent guidelines on iron deficiency anaemia (IDA) have confirmed the aetiological role of Helicobacter pylori (H pylori), but the relationship still remains controversial. METHODS: Starting in May 2009, searches of the following databases were undertaken: Medline (1966 to April...

  • Helicobacter pylori Infection and Anemia in Taiwanese Adults. Hsiang-Yao Shih; Fu-Chen Kuo; Wang, Sophie S. W.; Yi-Chang Liu; Meng-Chieh Wu; Yang-Pei Chang; Guei-Fen Chiu; Pi-Yu Chang; Deng-Chyang Wu; Ming-Chia Hsieh; Yao-Li Chen // Gastroenterology Research & Practice;2013, p1 

    Background. Chronic Helicobacter pylori infection and iron-deficiency anemia (IDA) are common in adults. Although the most common causes of IDA usually arise from the gastrointestinal tract, the association between chronic Helicobacter pylori infection and anemia remains unclear. Aim. To...

  • An Insight into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugees: A Cross-Sectional Study. Cherian, Sarah; Forbes, David A.; Cook, Angus G.; Sanfilippo, Frank M.; Kemna, Erwin H.; Swinkels, Dorine W.; Burgner, David P. // PLoS ONE;2008, Vol. 3 Issue 12, p1 

    Background: Hepcidin, a key regulator of iron homeostasis, is increased in response to inflammation and some infections, but the in vivo role of hepcidin, particularly in children with iron deficiency anemia (IDA) is unclear. We investigated the relationships between hepcidin, cytokines and iron...

  • Dramatic and prompt efficacy of Helicobacter pylori eradication in the treatment of severe refractory iron deficiency anemia in adults. Yamanouchi, Jun; Azuma, Taichi; Yakushijin, Yoshihiro; Hato, Takaaki; Yasukawa, Masaki // Annals of Hematology;Oct2014, Vol. 93 Issue 10, p1779 

    A letter to the editor is presented related to efficacy of Helicobacter pylori eradication in the treatment of refractory iron deficiency anemia in adults, that was published in the previous issue.

  • Iron deficiency anemia in Helicobacter pylori infected children: What is the role of gastric secretions and gastrointestinal mucosa? Baysoy, G.; Ertem, D.; Kotiloglu, E.; Pehlivanoglu, E. // Gut;Sep2002 Supplement 2, Vol. 51, pA85 

    The prevalance of iron deficiency anemia (IDA) is fairly high in children. It has been claimed that Helicobacter pylori (Hp)-induced hypochlorhydria reflected as high serum fasting gastrin levels might impair iron absorption. The role of Hp-related changes in histology and gastric secretions and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics