The Risk of Cancer in Patients with Generalized Anxiety Disorder: A Nationwide Population-Based Study

Shen, Cheng-Che; Hu, Yu-Wen; Hu, Li-Yu; Hung, Man-Hsin; Su, Tung-Ping; Huang, Min-Wei; Tsai, Chia-Fen; Ou, Shuo-Ming; Yen, Sang-Hue; Tzeng, Cheng-Hwai; Chiou, Tzeon-Jye; Chen, Tzeng-Ji; Liu, Chia-Jen
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Objective: To evaluate the risk of cancer among patients with generalized anxiety disorder (GAD) in a nationwide population-based dataset. Methods: We recruited newly-diagnosed GAD patients aged 20 years or older without antecedent cancer from the Taiwan National Health Insurance Research database between 2000–2010. Standardized incidence ratios (SIRs) of cancers were calculated in GAD patients, and the subgroup of GAD patients diagnosed by psychiatric specialists. Results: A total of 559 cancers developed among 19,793 GAD patients with a follow-up of 89,485 person-years (median follow-up of 4.34 years), leading to a significantly increased SIR of 1.14 [95% confidence interval (CI) 1.05–1.24]. Male GAD patients had a significantly increased SIR overall (1.30, 95% CI 1.15–1.46) and for lung and prostate cancer (1.77, 95% CI 1.33–2.30 and 2.17, 95% CI 1.56–2.93, respectively). Patients over 80 years of age also had a significantly increased SIR (1.56, 95% CI 1.25–1.92), especially in males. However, psychiatrist-diagnosed GAD patients did not show increased cancer risk relative to the general population, perhaps due to having fewer physical comorbidities than non-psychiatrist-diagnosed GAD patients. Conclusion: This study found that overall cancer risk is elevated among patients with GAD. The risk of lung and prostate cancer also increased in male patients with GAD. This increased cancer risk may be due to physical comorbidities and surveillance bias. Further prospective study is necessary to confirm these findings.


Related Articles

  • Association of Dialysis with the Risks of Cancers. Lin, Ming Yen; Kuo, Mei Chuan; Hung, Chi Chih; Wu, Wen Jeng; Chen, Li Tzong; Yu, Ming Lung; Hsu, Chih-Cheng; Lee, Chien-Hung; Chen, Hung-Chun; Hwang, Shang-Jyh // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Background: To increase the survival span after dialysis in patients with end-stage renal disease (ESRD), identifying specific cancer risks is crucial in the cancer screening of these patients. The aim of this study was to investigate the risks of various cancers in an incident dialysis group...

  • Human Insulin Does Not Increase Bladder Cancer Risk. Tseng, Chin-Hsiao // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Background: Whether human insulin can induce bladder cancer is rarely studied. Methods: The reimbursement databases of all Taiwanese diabetic patients from 1996 to 2009 were retrieved from the National Health Insurance. An entry date was set at 1 January 2004 and a total of 785,234 patients with...

  • Nonsmoker and "Nonnicotine" Hiring Policies: The Implications of Employment Restrictions for Tobacco Control. Voigt, Kristin // American Journal of Public Health;Nov2012, Vol. 102 Issue 11, p2013 

    Smoking has been restricted in workplaces for some time. A number of organizations with health promotion or tobacco control goals have taken the further step of implementing employment restrictions. These restrictions apply to smokers and, in some cases, to anyone testing positive on cotinine...

  • The Collateral Damage of Mass Incarceration: Risk of Psychiatric Morbidity Among Nonincarcerated Residents of High-Incarceration Neighborhoods. Hatzenbuehler, Mark L.; Keyes, Katherine; Hamilton, Ava; Uddin, Monica; Galea, Sandro // American Journal of Public Health;Jan2015, Vol. 105 Issue 1, p138 

    Objectives. We examined whether residence in neighborhoods with high levels of incarceration is associated with psychiatric morbidity among nonincarcerated community members. Methods. We linked zip code–linked information on neighborhood prison admissions rates to individual-level data on...

  • Challenges in Assessment and Diagnosis of Generalized Anxiety Disorder. Portman, Michael E.; Starcevic, Vladan; Beck, Aaron T. // Psychiatric Annals;Feb2011, Vol. 41 Issue 2, p79 

    The article reports on the challenges in the diagnosis and assessment of generalized anxiety disorder (GAD), a comorbid disease. The diagnostic criteria for GAD according to the Diagnostic Statistical Manual of Mental Disorders (DSM) is presented including excessive worry lasting over six...

  • Estimating cancer risk in relation to tritium exposure from routine operation of a nuclear-generating station in Pickering, Ontario. Wanigaratne, S.; Holowaty, E.; Jiang, H.; Norwood, T. A.; Pietrusiak, M. A.; Brown, P. // Chronic Diseases & Injuries in Canada;Sep2013, Vol. 33 Issue 4, p247 

    Introduction: Evidence suggests that current levels of tritium emissions from CANDU reactors in Canada are not related to adverse health effects. However, these studies lack tritium-specific dose data and have small numbers of cases. The purpose of our study was to determine whether tritium...

  • IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis. Wei Dai; Qing Zhou; Xuexin Tan; Changfu Sun // OncoTargets & Therapy;2014, Vol. 7, p703 

    Interleukin (IL)-17 has been shown to play an important role in the pathogenesis of inflammation and cancer. The IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms have been extensively investigated with cancer risk, but individually published results have been inconclusive. The aim of this...

  • Short Telomere Length, Cancer Survival, and Cancer Risk in 47102 Individuals. Weischer, Maren; Nordestgaard, Børge G.; Cawthon, Richard M.; Freiberg, Jacob J.; Tybjærg-Hansen, Anne; Bojesen, Stig E. // JNCI: Journal of the National Cancer Institute;4/3/2013, Vol. 105 Issue 7, p459 

    Background Recent meta-analyses have suggested that short telomere length was associated with increased risk of cancer. We therefore tested the hypotheses that short telomere length was associated with increased risk of cancer and with increased risk of early death after cancer. Methods We...

  • Renal Carcinoma After Childhood Cancer: A Report From the Childhood Cancer Survivor Study. Wilson, Carmen L.; Ness, Kirsten K.; Neglia, Joseph P.; Hammond, Sue; Shnorhavorian, Margarett; Leisenring, Wendy L.; Stovall, Marilyn; Robison, Leslie L.; Armstrong, Gregory T. // JNCI: Journal of the National Cancer Institute;4/3/2013, Vol. 105 Issue 7, p504 

    Adult survivors of childhood cancer are known to be at increased risk of subsequent malignancy, but only limited data exist describing the incidence and risk factors for secondary renal carcinoma. Among 14 358 5-year survivors diagnosed between 1970 and 1986, we estimated standardized incidence...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics