Respiratory Impairment and Systemic Inflammation in Cedar Asthmatics Removed from Exposure

Carlsten, Chris; Dybuncio, Anne; Pui, Mandy M.; Chan-Yeung, Moira
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Prior research has shown that removing occupational asthmatics from exposure does not routinely lead to significant improvements in respiratory impairment. These studies were of limited duration and factors determining recovery remain obscure. Our objective was to evaluate residual respiratory impairment and associated sputum and blood biomarkers in subjects with Western red cedar asthma after exposure cessation. Methods: Subjects previously diagnosed with cedar asthma, and removed from exposure to cedar dust for at least one year, were recruited. Subjects completed a questionnaire and spirometry. PC20 (methacholine concentration that produces 20% fall in FEV1 (forced expiratory volume at 1 second)) sputum cellularity and select Th1/Th2 (T helper cells 1 and 2) cytokine concentrations in peripheral blood were determined. The asthma impairment class was determined and multivariate analyses were performed to determine its relationship with sputum cell counts and serum cytokines. Results: 40 non-smoking males (mean age 62) were examined at a mean interval of 25 years from cedar asthma diagnosis and 17 years from last cedar exposure. 40% were in impairment class 2/3. On average, the PC20 had increased by 2.0 mg/ml; the FEV1 decreased by 1.5 L, with greater decrease in those with greater impairment. Higher impairment was associated with serum interferon-gamma (mean = 1.3 pg/ml in class 2/3 versus 0.62 pg/ml in class 0/1, p = 0.04), mainly due to the FEV1 component (correlation with interferon-gamma = −0.46, p = 0.005). Conclusion: Years after exposure cessation, patients with Western red cedar asthma have persistent airflow obstruction and respiratory impairment, associated with systemic inflammation.


Related Articles

  • Opinion: Childhood asthma: biomarking the spot.  // PharmaWatch: Monthly Review;Oct2005, Vol. 4 Issue 10, p27 

    Presents information about new research which has shown that childhood asthma control could be improved by using biomarkers. Focus on returning patients with asthma towards a disease-free state; Lack of any proven biomarkers for the optimal assessment and monitoring of asthma treatments;...

  • Differential Regulation of Inflammation and Immunity in Mild and Severe Experimental Asthma. Sagar, Seil; Verheijden, Kim A. T.; Georgiou, Niki A.; Garssen, Johan; Kraneveld, Aletta D.; Vos, Arjan P.; Folkerts, Gert // Mediators of Inflammation;2013, Vol. 2013, p1 

    This study aimed at exploring innate and adaptive immunity in allergic asthma by investigation of mRNA expression of pattern recognition receptors, T-cell-specific cytokines, and transcription factors. Mouse models for mild and severe asthma, with similar pathological characteristics observed in...

  • Work related asthma. Liss, G.M.; Tarlo, S.M. // Occupational & Environmental Medicine;Aug2002, Vol. 59 Issue 8, p503 

    Editorial. Provides information on occupational asthma (OA), the most frequently reported work related respiratory disease in most countries. Complications associated with the diagnosis of OA; Causes of work-related asthma; Definition of work-related asthma.

  • THE TWO SIDES OF THE "ENDOTOXIN COIN". Radon, K. // Occupational & Environmental Medicine;Jan2006, Vol. 63 Issue 1, p73 

    The article discusses positive and negative aspects of endotoxins. It is observed that exposure to endotoxins increases the chances of organic dust toxic syndrome, chronic bronchitis, and asthma-like syndrome. It has also been shown that exposure to endotoxins in the occupational and...

  • Can HRCT be used as a marker of airway remodelling in children with difficult asthma? Saglani, S.; Papaioannou, G.; Khoo, L.; Ujita, M.; Jeffery, P. K.; Owens, C.; Hansell, D. M.; Payne, D. N.; Bush, A. // Respiratory Research;2006, Vol. 7, p1 

    Background: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult asthma (DA), in whom RBM thickening is a...

  • What is the best strategy to reduce the burden of occupational asthma and allergy in bakers? Meijster, Tim; Warren, Nick; Heederik, Dick; Tielemans, Erik // Occupational & Environmental Medicine;Mar2011, Vol. 68 Issue 3, p176 

    Rationale Insight into the effectiveness of intervention strategies will help realise a decrease in the occupational disease burden from (allergic) respiratory diseases in the bakery population. Objectives To use a simulation model to assess the impact of different intervention strategies on the...

  • Chlamydia pneumoniae-Specific IgE Is Prevalent in Asthma and Is Associated with Disease Severity. Hahn, David L.; Schure, Allison; Patel, Katir; Childs, Tawanna; Drizik, Eduard; Webley, Wilmore // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Background: Several Chlamydia pneumoniae (Cp) biomarkers have been associated with asthma but Cp-specific IgE (Cp IgE) has not been investigated extensively. Our objective was to investigate Cp IgE in community adult asthma patients. Methods:(1) Prevalence of Cp IgE (measured by immunoblotting)...

  • Discovery of genetic difference between asthmatic children with high IgE level and normal IgE level by whole genome linkage disequilibrium mapping using 763 autosomal STR markers. Wang, Jiu-Yao; Lin, Cherry Guan-Ju; Bey, Monica Shian-Jy; Wang, Lingmei; Lin, Felicia Yi-Fang; Huang, Lichih; Wu, Lawrence Shih-Hsin // Journal of Human Genetics;May2005, Vol. 50 Issue 5, p249 

    The genome-wide linkage disequilibrium screen for loci associated with genetic difference between allergic and nonallergic asthma was conducted with 763 autosomal STR markers and included 190 asthmatic children. Evidence for association with differences between the two forms of asthma was...

  • Abdominal and Total Body Adiposity Markers in Asthmatic Patients. Morsi, Mohamed Galal // Journal of Medical Sciences;2009, Vol. 9 Issue 2, p59 

    This study aimed to evaluate the total and abdominal adiposity markers in asthmatic patients and their relation to asthma severity and PFTs. Seventy non-smoking adult asthmatics, aged 38.6&11.8, (42.9% male), were subjected to history, clinical and radiological examination, measurement of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics