Ten-a Affects the Fusion of Central Complex Primordia in Drosophila

Cheng, Xuebo; Jiang, Huoqing; Li, Weizhe; Lv, Hailong; Gong, Zhefeng; Liu, Li
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
The central complex of Drosophila melanogaster plays important functions in various behaviors, such as visual and olfactory memory, visual orientation, sleep, and movement control. However little is known about the genes regulating the development of the central complex. Here we report that a mutant gene affecting central complex morphology, cbd (central brain defect), was mapped to ten-a, a type II trans-membrane protein coding gene. Down-regulation of ten-a in pan-neural cells contributed to abnormal morphology of central complex. Over-expression of ten-a by C767-Gal4 was able to partially restore the abnormal central complex morphology in the cbd mutant. Tracking the development of FB primordia revealed that C767-Gal4 labeled interhemispheric junction that separated fan-shaped body precursors at larval stage withdrew to allow the fusion of the precursors. While the C767-Gal4 labeled structure did not withdraw properly and detached from FB primordia, the two fan-shaped body precursors failed to fuse in the cbd mutant. We propose that the withdrawal of C767-Gal4 labeled structure is related to the formation of the fan-shaped body. Our result revealed the function of ten-a in central brain development, and possible cellular mechanism underlying Drosophila fan-shaped body formation.


Related Articles

  • Differential Effects of Human L1CAM Mutations on Complementing Guidance and Synaptic Defects in Drosophila melanogaster. Kudumala, Sirisha; Freund, Julie; Hortsch, Michael; Godenschwege, Tanja A. // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    A large number of different pathological L1CAM mutations have been identified that result in a broad spectrum of neurological and non-neurological phenotypes. While many of these mutations have been characterized for their effects on homophilic and heterophilic interactions, as well as...

  • Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects.  // PLoS Genetics;Oct2010, Vol. 6 Issue 10, p1 

    No abstract available.

  • The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action. Fletcher, Rachael; Gribben, Christopher; Ma, Xuiquan; Burchfield, James G.; Thomas, Kristen C.; Krycer, James R.; James, David E.; Fazakerley, Daniel J. // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    The Niemann-Pick disease, type C1 (NPC1) gene encodes a transmembrane protein involved in cholesterol efflux from the lysosome. SNPs within NPC1 have been associated with obesity and type 2 diabetes, and mice heterozygous or null for NPC1 are insulin resistant. However, the molecular mechanism...

  • The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Miron, Mathieu; VerdĂș, Javier; Lachance, Pascal E.D.; Birnbaum, Morris J.; Lasko, Paul F.; Sonenberg, Nahum // Nature Cell Biology;Jun2001, Vol. 3 Issue 6, p596 

    The initiation factor 4E for eukaryotic translation (eIF4E) binds the messenger RNA 5'-cap structure and is important in the regulation of protein synthesis[SUP1]. Mammalian eIF4E activity is inhibited when the initiation factor binds to the translational repressors, the 4E-binding proteins...

  • Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Ruel, Laurent; Rodriguez, Ralph; Gallet, Armel; Lavenant-Staccini, Laurence; Therond, Pascal P. // Nature Cell Biology;Oct2003, Vol. 5 Issue 10, p907 

    The mechanisms involved in transduction of the Hedgehog (Hh) signal are of considerable interest to developmental and cancer biologists. Stabilization of the integral membrane protein Smoothened (Smo) at the plasma membrane is a crucial step in Hh signalling but the molecular events immediately...

  • The Rate of Concentration Change and How It Determines the Resolving Power of Olfactory Receptor Neurons. Tichy, Harald; Hellwig, Maria; Zopf, Lydia M.; Kloppenburg, Peter; Stengl, Monika // Frontiers in Physiology;12/27/2016, Vol. 7, p1 

    The response characteristics of olfactory receptor neurons (ORNs) and their corollary, the differential sensitivity and the resolving power, are fundamental to understand olfactory coding and the information extracted from a fluctuating olfactory signal. Previous work has focused on the temporal...

  • Restricting the spreading. Kritikou, Ekat // Nature Reviews Molecular Cell Biology;Mar2006, Vol. 7 Issue 3, p155 

    Presents two research on the role of lipid modifications in Hedgehog (Hh) signalling by affecting multimerization, Hh spreading and signalling activity. Comparison of the behavior of lipidated Hh with that of a non-cholesterol-modified Hh for in epithelial tissues; Analysis on the role Hh lipid...

  • The Contributions of Protein Kinase A and Smoothened Phosphorylation to Hedgehog Signal Transduction in Drosophila melanogaster. Qianhe Zhou; Apionishev, Sergey; Kalderon, Daniel // Genetics;Aug2006, Vol. 173 Issue 4, p2049 

    Protein kinase A (PKA) silences the Hedgehog (Hh) pathway in Drosophila in the absence of ligand by phosphorylating the pathway's transcriptional effector, Cubitus interruptus (Ci). Smoothened (Smo) is essential for Hh signal transduction but loses activity if three specific PKA sites or...

  • Jelly belly shapes up. Bussell, Katrin // Nature Reviews Molecular Cell Biology;Nov2003, Vol. 4 Issue 11, p827 

    Discusses research being done on a receptor and a signaling pathway downstream of the secreted protein Jelly belly in Drosophila melanogaster embryogenesis. Reference to two studies published in the 2003 issue of "Nature."


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics