The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population

Hu, Miao; Zhao, Lianying; Hu, Surong; Yang, Jingting
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Emerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) located in the miRNAs may influence the function of mature miRNAs and then affect the processing of carcinogenesis. It has been suggested that two common SNPs rs2910164 in miR-146a and rs3746444 in miR-499 are associated with susceptibility to hepatocellular carcinoma (HCC). However, published results are inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and HCC risk, we performed this meta-analysis. Methodology/Principal Findings: We have conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs3746444 with susceptibility to HCC in PubMed, ScienceDirect, Cochrane Central Register of Controlled Trials, and Chinese National Knowledge Infrastructure databases for the period up to Sep 10th, 2012. A total of 6 studies were identified with 2071 cases and 2350 controls for miR-146a rs2910164 polymorphism, 667 cases and 1006 controls for miR-499 rs3746444 polymorphism. It was found that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk of HCC in all genetic models. Similarly, subgroup analysis in Asian population showed no associations between the two SNPs and the susceptibility to HCC. Conclusions/Significance: This meta-analysis suggests that miR-146a rs2910164 and miR-499 rs3746444 polymorphisms may not be associated with the risk of HCC, especially for Asian population. However, well-designed studies with larger sample size and more detailed data are needed to confirm these conclusions.


Related Articles

  • Associations of miR-499 and miR-34b/c Polymorphisms with Susceptibility to Hepatocellular Carcinoma: An Evidence-Based Evaluation. Zhongxia Wang; Junhua Wu; Guang Zhang; Yin Cao; Chunping Jiang; Yitao Ding // Gastroenterology Research & Practice;2013, p1 

    Background. Hepatocellular carcinoma (HCC) represents the sixth common cancer in the world. Single nucleotide polymorphisms (SNPs) in microRNA genes may be associated with susceptibility to HCC. Recently, several studies have reported possible associations of SNPs miR-499 T>C rs3746444 and...

  • Molecular Evolution of Genetic Susceptibility to Hepatocellular Carcinoma. Ngamruengphong, Saowanee; Patel, Tushar // Digestive Diseases & Sciences;May2014, Vol. 59 Issue 5, p986 

    Background: Hepatocellular carcinoma (HCC) is a leading cancer-related cause of death worldwide. There are widespread global differences in HCC risk. Although the impact of geographic prevalence of specific causes of chronic liver disease on HCC is recognized, the contribution of the underlying...

  • MDM2 SNP309 rs2279744 Polymorphism and Gastric Cancer Risk: A Meta-Analysis. Ma, Yong; Bian, Jianmin; Cao, Hongyong // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Background: MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including gastric cancer....

  • Association between the CYP2E1 polymorphisms and lung cancer risk: a meta-analysis. Ye, Xiang-Hua; Song, Liang; Peng, Ling; Bu, Zhibin; Yan, Sen-Xiang; Feng, Jie; Zhu, Xin-Li; Liao, Xin-Biao; Yu, Xue-Lin; Yan, Danfang // Molecular Genetics & Genomics;Apr2015, Vol. 290 Issue 2, p545 

    The previous, published data on the association between CYP2E1 RsaI (rs2031920), DraI (rs6413432) polymorphisms and lung cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between lung cancer and CYP2E1 RsaI (5,074 cases and 6,828 controls from...

  • Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases. Gong, Wen-Feng; Zhong, Jian-Hong; Xiang, Bang-De; Ma, Liang; You, Xue-Mei; Zhang, Qiu-Ming; Li, Le-Qun // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Background: The onset and progression of breast cancer (BC) is influenced by many factors, including the single nucleotide polymorphism (SNP) rs13281615 at 8q24. However, studies of the potential association between rs13281615 at 8q24 and risk of BC have given inconsistent results. We performed...

  • Assessing the Impact of Differential Genotyping Errors on Rare Variant Tests of Association. Mayer-Jochimsen, Morgan; Fast, Shannon; Tintle, Nathan L. // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Genotyping errors are well-known to impact the power and type I error rate in single marker tests of association. Genotyping errors that happen according to the same process in cases and controls are known as non-differential genotyping errors, whereas genotyping errors that occur with different...

  • Y-SNP haplogroups related to the Yqh+ heteromorphism in the Mexican northwestern population. ROMO-MARTÍNEZ, ENRIQUE; MARTÍNEZ-CORTÉS, GABRIELA; BARAJAS-TORRES, REYNA; RUBI-CASTELLANOS, RODRIGO; MAGAÑA-TORRES, MARÍA; RANGEL-VILLALOBOS, HÉCTOR; GONZÁLEZ-GARCÍA, JUAN // Journal of Genetics;Dec2012, Vol. 91 Issue 3, p297 

    Morphological variation of the Y chromosome has been observed in different populations. This variation is mostly related to the heteromorphic Yq12 band, which is composed of a variable block of constitutive heterochromatin. The Yqh+ heteromorphism has a worldwide frequency of 2.85% and is...

  • Association study of miR-149 rs2292832 and miR-608 rs4919510 and the risk of hepatocellular carcinoma in a large-scale population. RUI WANG; JUN ZHANG; YANYUN MA; LINQI CHEN; SHICHENG GUO; XIAOJIAO ZHANG; YUNFANG MA; LIJUN WU; XIAOYU PEI; SIRAN LIU; JIUCUN WANG; HEPING HU; JIE LIU // Molecular Medicine Reports;2014, Vol. 10 Issue 5, p2736 

    Polymorphisms in pre-microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. The present study aimed to evaluate whether miR-149 rs2292832 (C>T) and miR-608 rs4919510 (G>C) are associated with the risk and...

  • Association of the miR-146aC>G, miR-149T>C, and miR-196a2T>C polymorphisms with gastric cancer risk and survival in the Greek population. Dikeakos, Panagiotis; Theodoropoulos, George; Rizos, Spyros; Tzanakis, Nikolaos; Zografos, George; Gazouli, Maria // Molecular Biology Reports;Feb2014, Vol. 41 Issue 2, p1075 

    MicroRNAs (miRNAs) play an important role in regulating gene expression at the post-transcriptional level and are involved in numerous physiological processes. Accumulating evidence suggests that single-nucleotide polymorphisms (SNPs) in human miRNA genes may affect miRNA biogenesis pathway and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics