TITLE

Aurora-A Identifies Early Recurrence and Poor Prognosis and Promises a Potential Therapeutic Target in Triple Negative Breast Cancer

AUTHOR(S)
Xu, Jie; Wu, Xing; Zhou, Wei-hua; Liu, An-wen; Wu, Jian-bing; Deng, Jin-yun; Yue, Cai-feng; Yang, Shao-bing; Wang, Jing; Yuan, Zhong-yu; Liu, Quentin
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Triple negative breast cancer (TNBC) acquires an unfavorable prognosis, emerging as a major challenge for the treatment of breast cancer. In the present study, 122 TNBC patients were subjected to analysis of Aurora-A (Aur-A) expression and survival prognosis. We found that Aur-A high expression was positively associated with initial clinical stage (P = 0.025), the proliferation marker Ki-67 (P = 0.001), and the recurrence rate of TNBC patients (P<0.001). In TNBC patients with Aur-A high expression, the risk of distant recurrence peaked at the first 3 years and declined rapidly thereafter, whereas patients with Aur-A low expression showed a relatively constant risk of recurrence during the entire follow-up period. Univariate and multivariate analysis showed that overexpression of Aur-A predicted poor overall survival (P = 0.002) and progression-free survival (P = 0.012) in TNBC. Furthermore, overexpression of Aur-A, associated with high Ki-67, predicted an inferior prognosis compared with low expression of both Aur-A and Ki-67. Importantly, we further found that Aur-A was overexpressed in TNBC cells, and inhibition of this kinase inhibited cell proliferation and prevented cell migration in TNBC. Our findings demonstrated that Aur-A was a potential therapeutic target for TNBC and inhibition of Aur-A kinase was a promising regimen for TNBC cancer therapy.
ACCESSION #
87625051

 

Related Articles

  • Evaluation of Ki67 Expression across Distinct Categories of Breast Cancer Specimens: A Population-Based Study of Matched Surgical Specimens, Core Needle Biopsies and Tissue Microarrays. Knutsvik, Gøril; Stefansson, Ingunn M.; Aziz, Sura; Arnes, Jarle; Eide, Johan; Collett, Karin; Akslen, Lars A. // PLoS ONE;Nov2014, Vol. 9 Issue 11, p1 

    Introduction: Tumor cell proliferation in breast cancer is strongly prognostic and may also predict response to chemotherapy. However, there is no consensus on counting areas or cut-off values for patient stratification. Our aim was to assess the matched level of proliferation by Ki67 when...

  • Breast cancer screening and diagnosis in the 21st century within the U.K. Murray, Philip J.; Wivell, Glynis; Denton, Erika // Post Reproductive Health;Sep2015, Vol. 21 Issue 3, p105 

    In the UK, breast cancer represents the most commonly diagnosed cancer in females and carries with it a significant morbidity and mortality. An established national screening programme is in place to identify those with the disease at an early stage in order to optimise treatment and prognosis....

  • An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ⩽40 years at breast cancer diagnosis. Maishman, T; Copson, E; Stanton, L; Gerty, S; Dicks, E; Durcan, L; Wishart, G C; Pharoah, P; Eccles, D // British Journal of Cancer;3/17/2015, Vol. 112 Issue 6, p983 

    Background:Breast cancer is the most common cancer in younger women (aged ⩽40 years) in the United Kingdom. PREDICT (http://www.predict.nhs.uk) is an online prognostic tool developed to help determine the best available treatment and outcome for early breast cancer. This study was conducted...

  • Male Breast Cancer. Yalaza, Metin; İnan, Aydın; Bozer, Mikdat // Meme Sagligi Dergisi / Journal of Breast Health;Jan2016, Vol. 12 Issue 1, p1 

    Male breast cancer (MBC) is a rare disease, accounting for less than 1% of all breast cancer diagnoses worldwide. Although breast carcinomas share certain characteristics in both genders, there are notable differences. Most studies on men with breast cancer are very small. Thus, most data on...

  • Diagnostic performance of ADCs in different ROIs for breast lesions. Wei Zhang; Guan-Qiao Jin; Jun-Jie Liu; Dan-Ke Su; Ning-Bin Luo; Dong Xie; Shao-Lv Lai; Xiang-Yang Huang; Wei-Li Huang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 8, p12096 

    Objective: The purpose of this study was to explore the diagnostic performance of apparent diffusion coefficient (ADC) values for breast lesions by different measuring methods and find out the optimum measuring method. Methods: ADCW-mean and ADCW-min were obtained by whole-measurement method,...

  • Risking 'Safety': Breast Cancer, Prognosis, and the Strategic Enterprise of Life. Ehlers, Nadine // Journal of Medical Humanities;Mar2016, Vol. 37 Issue 1, p81 

    Living in modern biopolitical risk culture might be seen as synonymous with living in prognosis time, in the sense that risk of illness is endlessly forecast (prognosticated) in the broad social arena. 'Safety,' in this context, is framed as the anticipatory guarding against risk or disease in...

  • Squamous cell carcinoma of the breast: particularity and clinical management. Xiao-Le Chen; Jie Luo; Fa-Liang Xu // International Journal of Clinical & Experimental Medicine;2016, Vol. 9 Issue 7, p14167 

    Objective: The clinical behavior and prognosis of breast squamous cell carcinoma (SCC) have not been fully characterized; this study aimed to further explore these issues. Methods: Twenty-three patients were identified as having primary SCC (PSCC) or metaplastic SCC (MSCC). Their...

  • Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients. Ren, Tingting; Zhang, Jian; Zhang, Jing; Liu, Xinping; Yao, Libo // Medical Oncology;Mar2013, Vol. 30 Issue 1, p1 

    The discoidin domain receptors, DDR1 and DDR2, have been linked with numerous human cancers. We sought to determine expression level and distribution of DDRs in human breast cancer, and investigate prognostic determinates to determine whether levels of DDRs could predict survival. Tumor samples...

  • Serum biomarker 3144 m/z for prognostic detection in Chinese postmenopausal breast cancer patients. Yun Gao; ShenHua Xu; Wenming Cao; Zhanhong Chen; Xiaojia Wang; Dehong Zou // Journal of Cancer Research & Therapeutics;2015 Sepcial Issue1, Vol. 11, pC68 

    Context: Breast cancer becomes more prevalent with advancing age. The increased risk of breast cancer needs to be considered when choosing a treatment plan and a kind of detection method for the postmenopausal woman. Better breast cancer prognostication may improve selection of patients for...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics