TITLE

A Key Role for Nectin-1 in the Ventral Hippocampus in Contextual Fear Memory

AUTHOR(S)
Fantin, Martina; van der Kooij, Michael A.; Grosse, Jocelyn; Krummenacher, Claude; Sandi, Carmen
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-interactions are important for the proper formation of synapses. In the hippocampus, nectin-1 and nectin-3 localize at puncta adherentia junctions and may play a role in synaptic plasticity, a mechanism essential for memory and learning. We evaluated the potential involvement of nectin-1 and nectin-3 in memory consolidation using an emotional learning paradigm. Rats trained for contextual fear conditioning showed transient nectin-1—but not nectin-3—protein upregulation in synapse-enriched hippocampal fractions at about 2 h posttraining. The upregulation of nectin-1 was found exclusively in the ventral hippocampus and was apparent in the synaptoneurosomal fraction. This upregulation was induced by contextual fear conditioning but not by exposure to context or shock alone. When an antibody against nectin-1, R165, was infused in the ventral-hippocampus immediately after training, contextual fear memory was impaired. However, treatment with the antibody in the dorsal hippocampus had no effect in contextual fear memory formation. Similarly, treatment with the antibody in the ventral hippocampus did not interfere with acoustic memory formation. Further control experiments indicated that the effects of ventral hippocampal infusion of the nectin-1 antibody in contextual fear memory cannot be ascribed to memory non-specific effects such as changes in anxiety-like behavior or locomotor behavior. Therefore, we conclude that nectin-1 recruitment to the perisynaptic environment in the ventral hippocampus plays an important role in the formation of contextual fear memories. Our results suggest that these mechanisms could be involved in the connection of emotional and contextual information processed in the amygdala and dorsal hippocampus, respectively, thus opening new venues for the development of treatments to psychopathological alterations linked to impaired contextualization of emotions.
ACCESSION #
87625031

 

Related Articles

  • Cyclic AMP Pathway Modifies Memory through Neural Cell Adhesion Molecule Alterations in the Rat Hippocampus. Razmi, Ali; Sahebgharani, Mousa; Khani, Mohammad Hossein; Paylakhi, Seyed Hassan; Faizi, Mehrdad; Zarrindast, Mohammad-Reza // Acta Medica Iranica;2014, Vol. 52 Issue 4, p246 

    Neural Cell Adhesion Molecules (NCAMs) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. This study investigated the possible role of cAMP pathway in the expression of hippocampal NCAM and its polysialylated derivative (PSA-NCAM). The following...

  • Ventral Tegmental Area Inactivation Suppresses the Expression of CA1 Long Term Potentiation in Anesthetized Rat. Ghanbarian, Elham; Motamedi, Fereshteh // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA). Modulatory effect of dopamine on hippocampal long term potentiation (LTP) has been studied before, but there are conflicting results and some limitations in previous reports. Most of these studies show a...

  • Chronic effects of venlafaxine on synaptophysin and neuronal cell adhesion molecule in the hippocampus of cerebral ischemic mice. Shaokuan Fang; Bin Yan; Daoyi Wang; Xiaoying Bi; Yanbo Zhang; Jue He; Haiyun Xu; Yi Yang; Jiming Kong; Jiang Wu; Xin-Min Li // Biochemistry & Cell Biology;Aug2010, Vol. 88 Issue 4, p655 

    Venlafaxine, a novel antidepressant, inhibits serontonin and norepinephrine reuptake in the presynaptic cleft. Unlike typical selective serontonin reuptake inhibitors (SSRIs), venlafaxine may have modulatory effects on nerve terminals and neuronal plasticity. Our preliminary data found that 5...

  • Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2. Costa-Mattioli, Mauro; Gobert, Delphine; Harding, Heather; Herdy, Barbara; Azzi, Mounia; Bruno, Martin; Bidinosti, Michael; Ben Mamou, Cyrinne; Marcinkiewicz, Edwige; Yoshida, Madoka; Imataka, Hiroaki; Cuello, A. Claudio; Seidah, Nabil; Sossin, Wayne; Lacaille, Jean-Claude; Ron, David; Nader, Karim; Sonenberg, Nahum // Nature;8/25/2005, Vol. 436 Issue 7054, p1166 

    Studies on various forms of synaptic plasticity have shown a link between messenger RNA translation, learning and memory. Like memory, synaptic plasticity includes an early phase that depends on modification of pre-existing proteins, and a late phase that requires transcription and synthesis of...

  • IN BRIEF.  // Nature Reviews Neuroscience;Mar2007, Vol. 8 Issue 3, p169 

    The article presents several abstracts of neuroscience. They include "GABAergic spill-over transmission onto hippocampal mossy fiber boutons," by H. Alle and colleagues, "A deficit in the ability to form new human memories without sleep," by S.-S. Yoo and colleagues and "Molecular markers of...

  • Temporal Changes in Prosaposin Expression in the Rat Dentate Gyrus after Birth. Morishita, Midori; Nabeka, Hiroaki; Shimokawa, Tetsuya; Miyawaki, Kyojy; Doihara, Takuya; Saito, Shouichiro; Kobayashi, Naoto; Matsuda, Seiji // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Neurogenesis in the hippocampal dentate gyrus occurs constitutively throughout postnatal life. Adult neurogenesis includes a multistep process that ends with the formation of a postmitotic and functionally integrated new neuron. During adult neurogenesis, various markers are expressed, including...

  • Independent rate and temporal coding in hippocampal pyramidal cells. Huxter, John; Burgess, Neil; O'Keefe, John // Nature;10/23/2003, Vol. 425 Issue 6960, p828 

    In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes...

  • Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning. Lonergan, Mary E.; Gafford, Georgette M.; Jarome, Timothy J.; Helmstetter, Fred J. // Neural Plasticity;2010, Vol. 2010, p1 

    Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity underlying learning and memory. This study explored the temporal expression profiles of...

  • Sleep and plasticity. Ribeiro, Sidarta // Pflugers Archiv European Journal of Physiology;Jan2012, Vol. 463 Issue 1, p111 

    While there is ample agreement that the cognitive role of sleep is explained by sleep-dependent synaptic changes, consensus is yet to be established as to the nature of these changes. Some researchers believe that sleep promotes global synaptic downscaling, leading to a non-Hebbian reset of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics