TITLE

Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold Immersion in Primary Contact Urticaria

AUTHOR(S)
Meyer, Joseph; Gorbach, Alexander M.; Liu, Wei-Min; Medic, Nevenka; Young, Michael; Nelson, Celeste; Arceo, Sarah; Desai, Avanti; Metcalfe, Dean D.; Komarow, Hirsh D.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: While a number of the consequences of mast cell degranulation within tissues have been documented including tissue-specific changes such as bronchospasm and the subsequent cellular infiltrate, there is little known about the immediate effects of mast cell degranulation on the associated vasculature, critical to understanding the evolution of mast cell dependent inflammation. Objective: To characterize the microcirculatory events that follow mast cell degranulation. Methodology/Principal Findings: Perturbations in dermal blood flow, temperature and skin color were analyzed using laser-speckle contrast imaging, infrared and polarized-light colorimetry following cold-hand immersion (CHI) challenge in patients with cold-induced urticaria compared to the response in healthy controls. Evidence for mast cell degranulation was established by documentation of serum histamine levels and the localized release of tryptase in post-challenge urticarial biopsies. Laser-speckle contrast imaging quantified the attenuated response to cold challenge in patients on cetirizine. We found that the histamine-associated vascular response accompanying mast cell degranulation is rapid and extensive. At the tissue level, it is characterized by a uniform pattern of increased blood flow, thermal warming, vasodilation, and recruitment of collateral circulation. These vascular responses are modified by the administration of an antihistamine. Conclusions/Significance: Monitoring the hemodynamic responses within tissues that are associated with mast cell degranulation provides additional insight into the evolution of the acute inflammatory response and offers a unique approach to assess the effectiveness of treatment intervention.
ACCESSION #
87624916

 

Related Articles

  • Advances in mast cell biology: new understanding of heterogeneity and function. Moon, T. C.; St Laurent, C. D.; Morris, K. E.; Marcet, C.; Yoshimura, T.; Sekar, Y.; Befus, A. D. // Mucosal Immunology (1933-0219);Mar2010, Vol. 3 Issue 2, p111 

    Mast cells are classically viewed as effector cells of IgE-mediated allergic diseases. However, over the last decade our understanding has been enriched about their roles in host defense, innate and adaptive immune responses, and in homeostatic responses, angiogenesis, wound healing, tissue...

  • Characterization of Mast Cell Secretory Granules and Their Cell Biology. Azouz, Nurit Pereg; Hammel, Ilan; Sagi-Eisenberg, Ronit // DNA & Cell Biology;Oct2014, Vol. 33 Issue 10, p647 

    Exocytosis and secretion of secretory granule (SG) contained inflammatory mediators is the primary mechanism by which mast cells exert their protective immune responses in host defense, as well as their pathological functions in allergic reactions and anaphylaxis. Despite their central role in...

  • Classification and Treatment of Urticaria: A Brief Review. Guldbakke, Kjetil Kristoffer; Khachemoune, Amor // Dermatology Nursing;Oct2005, Vol. 17 Issue 5, p361 

    This article focuses on the classification and treatment of urticaria. Urticaria is characterized by short-lived swellings of the skin, mouth, and genitalia related to a transient leakage of plasma from small blood vessels into the surrounding connective tissues. Urticaria may manifest with...

  • Lipid Rafts in Mast Cell Biology. Souza, Adriana Maria Mariano Silveirae; Mazucato, Vivian Marino; Jamur, Maria Célia; Oliver, Constance // Journal of Lipids;2011, p1 

    Mast cells have long been recognized to have a direct and critical role in allergic and inflammatory reactions. In allergic diseases, these cells exert both local and systemic responses, including allergic rhinitis and anaphylaxis. Mast cellmediators are also related to many chronic inflammatory...

  • Vaccines: Mast cells key to new vaccine adjuvants. Flemming, Alexandra // Nature Reviews Drug Discovery;Jul2008, Vol. 7 Issue 7, p560 

    The article focuses on the research conducted by J. B. McLachlan and his colleagues on the role of mast cell (MC). The research team examined the effects of MC activators on the development of the adaptive immune response by administering the compound 48/80 (c48/80), together with the protein...

  • Solitary Mastocytoma of Infancy. Kilburn, H. Lee // Clinical Pediatrics;Jan1974, Vol. 13 Issue 1, p60 

    Presents cases of solitary mastocytoma. Classification of the mastocytosis syndrome as a spectrum of transitional forms based on the clinical presentation; Presentation of cutaneous mastocytosis as an isolated lesion or as generalized lesions; Presentation of systemic mastocytosis with or...

  • Dermal Mast Cell Activation by Autoantibodies Against the High Affinity IgE Receptor in Chronic Urticaria. Niimi, Naomasa; Francis, David M.; Kermani, Faiz; O'Donnell, Brigid F.; Hide, Michihiro; Kobza-Black, Anne; Winkelmann, Richard K.; Greaves, Malcolm W.; Barr, Robert M. // Journal of Investigative Dermatology;May96, Vol. 106 Issue 5, p1001 

    Previous studies identified autoantibodies against the IgE high affinity receptor α-chain, FcεRIα, in sera of selected patients with severe chronic idiopathic urticaria. We have now determined the incidence of anti-FcεRIα autoantibodies in a group of 163 patients. Intradermal...

  • Antieosinophilic activity of various subfractions of leaves of Vitex negundo. Patel, Jignesh I.; Deshpande, Shrikalp S. // International Journal of Nutrition, Pharmacology, Neurological D;Feb2013, Vol. 3 Issue 2, p135 

    Aim: The present study was undertaken to isolate and identify active constituent of leaves of Vitex negundo for their actions on bronchial hyperresponsiveness. Materials and Methods: Effects of aqueous subfraction, acetone subfraction, and chloroform sub-fraction on bronchial hyperresponsiveness...

  • Anaphylactic reactions after cisatracurium administration in two patients. Yangin Yoon; Byungdoo Lee; Hyung-Seok Seo; Jiyoun Bang; Seung Il Ha; Jun-Gol Song // Korean Journal of Anesthesiology;Aug2013, Vol. 65 Issue 2, p147 

    Cisatracurium was initially characterized to have no evident histamine-releasing potential with excellent cardiovascular stability. However, severe anaphylactic reactions to cisatracurium that resulted in bronchospasms and cardiovascular collapse have been reported worldwide. Two cases of severe...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics