Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study

Jünemann, Anselm G. M.; Stopa, Piotr; Michalke, Bernhard; Chaudhri, Anwar; Reulbach, Udo; Huchzermeyer, Cord; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich E.; Zrenner, Eberhart; Rejdak, Robert
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Trace elements might play a role in the complex multifactorial pathogenesis of age-related macular degeneration (AMD). The aim of this study was to measure alterations of trace elements levels in aqueous humor of patients with non-exsudative (dry) AMD. For this pilot study, aqueous humor samples were collected from patients undergoing cataract surgery. 12 patients with dry AMD (age 77.9±6.62, female 8, male 4) and 11 patients without AMD (age 66.6±16.7, female 7, male 4) were included. Aqueous levels of cadmium, cobalt, copper, iron, manganese, selenium, and zinc were measured by use of Flow-Injection-Inductively-Coupled-Plasma-Mass-Spectrometry (FI-ICP-MS), quality controlled with certified standards. Patients with AMD had significantly higher aqueous humor levels of cadmium (median: 0.70 µmol/L, IQR: 0.40–0.84 vs. 0.06 µmol/L; IQR: 0.01–.018; p = 0.002), cobalt (median: 3.1 µmol/L, IQR: 2.62–3.15 vs. 1.17 µmol/L; IQR: 0.95–1.27; p<0.001), iron (median: 311 µmol/L, IQR: 289–329 vs. 129 µmol/L; IQR: 111–145; p<0.001) and zinc (median: 23.1 µmol/L, IQR: 12.9–32.6 vs. 5.1 µmol/L; IQR: 4.4–9.4; p = 0.020) when compared with patients without AMD. Copper levels were significantly reduced in patients with AMD (median: 16.2 µmol/L, IQR: 11.4–31.3 vs. 49.9 µmol/L; IQR: 32.0–.142.0; p = 0.022) when compared to those without. No significant differences were observed in aqueous humor levels of manganese and selenium between patients with and without AMD. After an adjustment for multiple testing, cadmium, cobalt, copper and iron remained a significant factor in GLM models (adjusted for age and gender of the patients) for AMD. Alterations of trace element levels support the hypothesis that cadmium, cobalt, iron, and copper are involved in the pathogenesis of AMD.


Related Articles

  • Risk factors for exudative age-related macular degeneration in a large French case-control study. Zerbib, Jennyfer; Delcourt, Cécile; Puche, Nathalie; Querques, Giuseppe; Cohen, Salomon; Sahel, José; Korobelnik, Jean-François; Goff, Mélanie; Souied, Eric // Graefe's Archive of Clinical & Experimental Ophthalmology;Jun2014, Vol. 252 Issue 6, p899 

    Purpose: The purpose of the CAP (Creteil AMD PHRC-funded) Study was to analyze risk factors of exudative age-related macular degeneration (AMD) in a large French case-control population. Patients and methods: One thousand and twenty-four patients with exudative AMD and 275 controls were...

  • ARMD's hereditary link probed. Guttman, Cheryl // Ophthalmology Times;07/15/96, Vol. 21 Issue 20, p15 

    Reports on age-related macular degeneration (ARMD). Concept as a heritable disorder; Gene mapping; Implications for future research.

  • Gaining Ground In the War on AMD. Richer, Stuart // Review of Optometry;5/15/2004, Vol. 14 Issue 5, p78 

    Discusses the etiology and potential treatments for age-related macular degeneration (AMD). Common risk factors and associations; Diagnostic tests; Findings from the Age-Related Eye Disease Study (AREDS); Public health implications of AREDS; Laser therapy for AMD; AMD drug trials; AMD surgery. ...

  • Dear Doctor. Eisenberg, Jeffrey S. // Review of Optometry;11/15/2004 Supplement, Vol. 141, p3 

    Cites several studies on retinal disease in the U.S. Prevalence of blindness or low vision among older Americans; Estimation of the number of people with diabetic retinopathy; Result of survey on the incidence of age-related macular degeneration in the Hispanic American community.

  • MACULAR DEGENERATION EPIDEMIC. Pirisi, Angela // Life Extension;May2002, Vol. 8 Issue 5, p50 

    Focuses on the retinal degeneration epidemic. Effect of aging process on human eye; Implication of the diminishing concentrations of rhodopsin; Importance of carotenoids on maintaining eye health.

  • Smoke gets in your eyes.  // Total Health;Dec98/Jan99, Vol. 20 Issue 5, p10 

    Reveals that smoking may contribute to age-related macular degeneration (ARMD), a leading cause of legal blindness in the United States (US). Number of older people in the US affected by ARMD; Number of cigarette packs a day that may contribute to the risk of developing ARMD.

  • Low-intensity diode laser photocoagulation studied in ARMD. Guttman, Cheryl; Friberg, Thomas R. // Ophthalmology Times;12/01/98, Vol. 23 Issue 23, p19 

    Reports on an ongoing clinical trial that is evaluating the use of diode laser photocoagulation with subthreshold doses as a treatment for patients with age-related macular degeneration (ARMD). Follow-up to a pilot study where subthreshold diode laser treatment producing invisible burns was...

  • Visual hallucinations and Charles Bonnet syndrome after photodynamic therapy for age related macular degeneration. Cohen S Y; Bulik A; Tadayoni R; Quentel G // British Journal of Ophthalmology;Aug2003, Vol. 87 Issue 8, p977 

    AIMS: To report on visual hallucinations and Charles Bonnet syndrome (CBS) that may occur in patients with age related macular degeneration (AMD) treated by photodynamic therapy (PDT) with verteporfin for choroidal neovascularisation (CNV). METHODS: 100 consecutive patients were asked to respond...

  • Kale, Collards And Spinach Beat Carrots For Protecting Aging Eyes. Golub, Catherine // Environmental Nutrition;Apr2001, Vol. 24 Issue 4, p1 

    Reports the effectiveness of kale, collards and spinach over carrots in preventing the occurrence of age-related macular degeneration (ARMD). ARMD as the leading cause of blindness; Distinction of ARMD from cataracts; Low risk of ARMD in people with high intakes of antioxidant carotenoids.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics