TITLE

The Relationship between Cortical Blood Flow and Sub-Cortical White-Matter Health across the Adult Age Span

AUTHOR(S)
Chen, J. Jean; Rosas, H. Diana; Salat, David H.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Degeneration of cerebral white matter is commonly observed in aging, and the associated degradation in neural connectivity contributes to cognitive decline in older adults. Vascular dysfunction has been implicated as a potential mechanism for general age-related neural tissue deterioration; however, no prior study has examined the direct relationship between cortical vascular health and subcortical white-matter integrity. In this work, we aimed to determine whether blood supply to the brain is associated with microstructural integrity of connective tissue, and whether such associations are regionally specific and mainly accounted for by aging. We examined the association between cerebral blood flow (CBF) in the cortical mantle, measured using arterial spin labeling (ASL), and subcortical white-matter integrity, measured using diffusion tensor imaging (DTI), in a group of healthy adults spanning early to late adulthood. We found cortical CBF to be significantly associated with white-matter integrity throughout the brain. In addition, these associations were only partially tied to aging, as they remained even when statistically controlling for age, and when restricting the analyses to a young subset of the sample. Furthermore, vascular risk was not a prominent determinant of these effects. These findings suggest that the overall blood supply to the brain is an important indicator of white-matter health in the normal range of variations amongst adults, and that the decline in CBF with advancing age may potentially exacerbate deterioration of the connective anatomy of the brain.
ACCESSION #
87624877

 

Related Articles

  • Cerebral blood flow in Alzheimer's disease. Roher, Alex E.; Debbins, Josef P.; Malek-Ahmadi, Michael; Chen, Kewei; Pipe, James G.; Maze, Sharmeen; Belden, Christine; Maarouf, Chera L.; Thiyyagura, Pradeep; Hua Mo; Hunter, Jesse M.; Kokjohn, Tyler A.; Walker, Douglas G.; Kruchowsky, Jane C.; Belohlavek, Marek; Sabbagh, Marwan N.; Beach, Thomas G. // Vascular Health & Risk Management;2012 Part 2, Vol. 8, p599 

    Background: Alzheimer's disease (AD) dementia is a consequence of heterogeneous and complex interactions of age-related neurodegeneration and vascular-associated pathologies. Evidence has accumulated that there is increased atherosclerosis/arteriosclerosis of the intracranial arteries in AD and...

  • Dynamics of brain structure and cognitive function in the Alzheimer's disease neuroimaging initiative. Song, Xiaowei; Mitnitski, Arnold; Zhang, Ningnannan; Chen, Wei; Rockwood, Kenneth // Journal of Neurology, Neurosurgery & Psychiatry;Jan2013, Vol. 84 Issue 1, p71 

    Background: On average, cognition declines as people age, but improvement can also occur. Objective: To evaluate the dynamics of age-related changes in brain structure and cognitive function in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) and in healthy control...

  • Autism and Sensory Processing Disorders: Shared White Matter Disruption in Sensory Pathways but Divergent Connectivity in Social-Emotional Pathways. Chang, Yi-Shin; Owen, Julia P.; Desai, Shivani S.; Hill, Susanna S.; Arnett, Anne B.; Harris, Julia; Marco, Elysa J.; Mukherjee, Pratik // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Over 90% of children with Autism Spectrum Disorders (ASD) demonstrate atypical sensory behaviors. In fact, hyper- or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment is now included in the DSM-5 diagnostic criteria. However, there are children with...

  • The Complex and Multifactorial Nature of Alzheimer's Disease. Alkadhi, Karim; Eriksen, Jason // Current Neuropharmacology;Dec2011, Vol. 9 Issue 4, p586 

    No abstract available.

  • New Insights on Developmental Dyslexia Subtypes: Heterogeneity of Mixed Reading Profiles. Zoubrinetzky, Rachel; Bielle, Frédérique; Valdois, Sylviane // PLoS ONE;Jun2014, Vol. 9 Issue 6, p1 

    We examined whether classifications based on reading performance are relevant to identify cognitively homogeneous subgroups of dyslexic children. Each of the 71 dyslexic participants was selected to have a mixed reading profile, i.e. poor irregular word and pseudo-word reading performance...

  • The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage. Østergaard, Leif; Aamand, Rasmus; Karabegovic, Sanja; Tietze, Anna; Blicher, Jakob Udby; Mikkelsen, Irene Klærke; Iversen, Nina Kerting; Secher, Niels; Engedal, Thorbjørn Søndergaard; Anzabi, Mariam; Jimenez, Eugenio Gutierrez; Cai, Changsi; Koch, Klaus Ulrik; Næss-Schmidt, Erhard Trillingsgaard; Obel, Annette; Juul, Niels; Rasmussen, Mads; Sørensen, Jens Christian Hedemann // Journal of Cerebral Blood Flow & Metabolism;Dec2013, Vol. 33 Issue 12, p1825 

    The mortality after aneurysmal subarachnoid hemorrhage (SAH) is 50%, and most survivors suffer severe functional and cognitive deficits. Half of SAH patients deteriorate 5 to 14 days after the initial bleeding, so-called delayed cerebral ischemia (DCI). Although often attributed to vasospasms,...

  • Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Lace, G.; Savva, G. M.; Forster, G.; de Silva, R.; Brayne, C.; Matthews, F. E.; Barclay, J. J.; Dakin, L.; Ince, P. G.; Wharton, S. B. // Brain: A Journal of Neurology;May2009, Vol. 132 Issue 5, p1324 

    Deposits of abnormally phosphorylated tau protein are found in numerous neurodegenerative disorders; the ‘tauopathies’, which include Alzheimers and Picks diseases, but tau pathology is also found in the ageing brain. Variation in tau pathology in brain ageing and its relationship...

  • ApoER2 and VLDLr Are Required for Mediating Reelin Signalling Pathway for Normal Migration and Positioning of Mesencephalic Dopaminergic Neurons. Sharaf, Ahmed; Bock, Hans H.; Spittau, Björn; Bouché, Elisabeth; Krieglstein, Kerstin // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    The migration of mesencephalic dopaminergic (mDA) neurons from the subventricular zone to their final positions in the substantia nigra compacta (SNc), ventral tegmental area (VTA), and retrorubral field (RRF) is controlled by signalling from neurotrophic factors, cell adhesion molecules (CAMs)...

  • Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice. Toshio Takeda // Neurochemical Research;Apr2009, Vol. 34 Issue 4, p639 

    Abstract  The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968....

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics