TITLE

Efficacy and Safety of Traditional Chinese Medicine for Diabetes: A Double-Blind, Randomised, Controlled Trial

AUTHOR(S)
Ji, Linong; Tong, Xiaolin; Wang, Hongyuan; Tian, Haoming; Zhou, Huimin; Zhang, Lili; Li, Qifu; Wang, Yizhong; Li, Hongmei; Liu, Min; Yang, Hongjie; Gao, Yanbin; Li, Yan; Li, Quanmin; Guo, Xiaohui; Yang, Gangyi; Zhang, Zhongai; Zhou, Zhiguang; Ning, Guang; Chen, Yingli
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Treatment of diabetes mellitus with Traditional Chinese Medicine has a long history. The aim of this study is to establish the safety and efficacy of traditional Chinese medicine combined with glibenclamide to treat type 2 diabetes mellitus. Methods: In a controlled, double blind, multicentre non-inferiority trial, 800 patients with unsatisfactory glycemic control (fasting glucose 7–13 mmol/L and HbA1c 7–11%) were randomly assigned to receive Xiaoke Pill, a compound of Chinese herbs combined with glibenclamide, or Glibenclamide in two study groups – drug naive group, and patients previously treated with metformin monotherapy (metformin group). Outcome measures at 48 weeks were the incidence and rate of hypoglycemia, mean difference in HbA1c, and proportion of patients with HbA1c<6.5%. Findings: In drug naïve group, the total hypoglycemia rate and the mild hypoglycemic episode in the Xiaoke Pill arm were 38% (p = 0.024) and 41% (p = 0.002) less compared to Glibenclamide arm; in Metformin group, the average annual rate of hypoglycemia was 62% lower in Xiaoke Pill arm (p = 0.003). Respective mean changes in HbA1c from baseline were −0.70% and −0.66% for Xiaoke Pill and Glibenclamide, with a between-group difference (95% CI) of −0.04% (−0.20, 0.12) in the drug naïve group, and those in metformin group were −0.45% and −0.59%, 0.14% (−0.12, 0.39) respectively. The respective proportions of patients with a HbA1c level <6.5% were 26.6% and 23.4% in the drug naïve group and 20.1% and 18.9% in the metformin group. Interpretation: In patients with type 2 diabetes and inadequate glycaemic control, treatment with Xiaoke Pill led to significant reduction in risk of hypoglycemia and similar improvements in glycemic control after 48 weeks compared to Glibenclamide. Trial Registration: Chinese Clinical Trial Register number, ChiCTR-TRC-08000074
ACCESSION #
87624850

 

Related Articles

  • Wnt signalling sees spots. Povelones, Michael; Nusse, Roel // Nature Cell Biology;Nov2002, Vol. 4 Issue 11, pE249 

    The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt-Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the...

  • Alliance for cellular signaling: Into unknown territory. Abbott, Alison // Nature;12/12/2002, Vol. 420 Issue 6916, p600 

    Focuses on Alliance for Cellular Signaling's aim to explore the way in which research in cell biology is conducted. Plan to collate existing information about components of signaling pathways; Generation of robust data about pathways into two types of mouse cell; Development of the Molecule...

  • Proteomic and Computational Methods in Systems Modeling of Cellular Signaling. Kleppe, R.; Kjarland, E.; Selheim, F. // Current Pharmaceutical Biotechnology;Jun2006, Vol. 7 Issue 3, p135 

    Cellular signaling lies at the core of cellular behavior, and is central for the understanding of many pathologicconditions. To comprehend how signal transduction is orchestrated at the molecular level remains the ultimate challengefor cell biology. In the last years there has been a revolution...

  • Intercellular adhesion, signalling and the cytoskeleton. Jamora, Colin; Fuchs, Elaine // Nature Cell Biology;Apr2002, Vol. 4 Issue 4, pE101 

    Connections between the cytoskeleton and intercellular junctions profoundly influence cell shape and motility. It is becoming increasingly clear that in addition to structural functions, components of the adhesion apparatus also possess signalling capabilities. Recent studies suggest that their...

  • Beyond structure, to survival: activation of Stat3 by cadherin engagement. Raptis, Leda; Arulanandam, Rozanne; Vultur, Adina; Geletu, Mulu; Chevalier, Sébastien; Feracci, Hélène // Biochemistry & Cell Biology;Dec2009, Vol. 87 Issue 6, p835 

    Cells in normal tissues or in tumors have extensive opportunities for adhesion to their neighbors and the importance of cell to cell contact in the study of fundamental cellular processes is beginning to emerge. In this review, we discuss recent evidence of dramatic changes in the activity of an...

  • Crk family adaptors—signalling complex formation and biological roles. Feller, Stephan M // Oncogene;10/1/2001 Review, Vol. 20 Issue 44, p6348 

    Crk family adaptors are widely expressed and mediate the timely formation of signal transduction protein complexes upon a variety of extracellular stimuli, including various growth and differentiation factors. Selective formation of multi-protein complexes by the Crk and Crk-like (CRKL) proteins...

  • The ubiquitin connection. Riezman, Howard // Nature;3/28/2002, Vol. 416 Issue 6879, p381 

    Focuses on cell biology. Efforts of biologists in the use of the ubiquitin molecule in different ways; Regulation on the cell-to-cell signalling by internalizing activated receptors; Discussion on the process of endocytosis.

  • Cell Communication and Signaling is becoming the official journal of the Signal Transduction Society. Feller, Stephan M.; Hass, Ralf; Janssen, Ottmar; Friedrich, Karlheinz // Cell Communication & Signaling;2008, Vol. 6, Special section p1 

    The authors focus on the selection of "Cell Communication and Signaling" as the official journal of the Signal Transduction Society (STS). They note the aim of the periodical and the STS to play an active part in the signal transduction research community by offering a forum for the speedy...

  • Editorial of the Special Issue: Signaling Molecules and Signal Transduction in Cells. Schlossmann, Jens // International Journal of Molecular Sciences;Jun2013, Vol. 14 Issue 6, p11438 

    In the special issue "Signaling Molecules and Signal Transduction in Cells" authors were invited to submit papers regarding important and novel aspects of extra- and intracellular signaling which have implications on physiological and pathophysiological processes. These aspects included...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics