TITLE

Roles and Mechanism of miR-199a and miR-125b in Tumor Angiogenesis

AUTHOR(S)
He, Jun; Jing, Yi; Li, Wei; Qian, Xu; Xu, Qing; Li, Feng-Shan; Liu, Ling-Zhi; Jiang, Bing-Hua; Jiang, Yue
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
MicroRNAs (miRNAs) have been shown to be involved in different aspects of cancer biology including tumor angiogenesis. In this study, we identified that two miRNAs, miR-199a and miR-125b were downregulated in ovarian cancer tissues and cell lines. Overexpression of miR-199a and miR-125b inhibited tumor-induced angiogenesis associated with the decrease of HIF-1α and VEGF expression in ovarian cancer cells. Moreover, the levels of miR-199a and miR-125b were negatively correlated with VEGF mRNA levels in ovarian tissues. We further showed that direct targets of miR-199a and miR-125b HER2 and HER3 were functionally relevant. Forced expression of HER2 and HER3 rescued miR-199a- and miR-125b-inhibiting angiogenesis responses and Akt/p70S6K1/HIF-1α pathway. This study provides a rationale for new therapeutic approach to suppress tumor angiogenesis using miR-199a, miR-125b, or their mimics for ovarian cancer treatment in the future.
ACCESSION #
87624800

 

Related Articles

  • Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma. Zhu, Jing; Zhang, Shu; Gu, Liying; Di, Wen // Carcinogenesis;Dec2012, Vol. 33 Issue 12, p2334 

    Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1–DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer...

  • Interactome of Radiation-Induced microRNA-Predicted Target Genes. Lhakhang, Tenzin W.; Chaudhry, M. Ahmad // Comparative & Functional Genomics;2012, p1 

    The microRNAs (miRNAs) function as global negative regulators of gene expression and have been associated with a multitude of biological processes. The dysfunction of the microRNAome has been linked to various diseases including cancer. Our laboratory recently reported modulation in the...

  • Nuclear �-catenin localization is not sufficient for canonical Wnt signaling activation in human melanoma cell lines. Kulikova, K.; Posvyatenko, A.; Gnuchev, N.; Georgiev, G.; Kibardin, A.; Larin, S. // Molecular Biology;Oct2011, Vol. 45 Issue 5, p816 

    In most cases, advanced stages of melanoma are practically incurable due to high metastatic potential of tumor cells. Multiple observations support the idea that aberrations in the Wnt signaling pathway play a significant role in melanoma development and progression. Canonical Wnt signaling...

  • Role of Lefty in the anti tumor activity of human adult liver stem cells. Cavallari, C; Fonsato, V; Herrera, M B; Bruno, S; Tetta, C; Camussi, G // Oncogene;2/14/2013, Vol. 32 Issue 7, p819 

    Recent studies demonstrated that factors derived from embryonic stem cells inhibit the tumorigenicity of a variety of cancer cell lines. Embryonic stem cell-secreted Lefty, an inhibitor of Nodal-signalling pathway, was implicated in reprogramming cancer cells. Whether adult stem cells exhibited...

  • Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth. Wang, Zhan-xiang; Chen, Yu-ying; Li, Bo-an; Tan, Guo-wei; Liu, Xi-yao; Shen, Shang-hang; Zhu, Hong-wei; Wang, Hai-dong // Journal of Neuro-Oncology;Nov2010, Vol. 100 Issue 1, p31 

    Gliomas are common malignant tumors of the human neural system, and Wnt signaling activation is closely related to glioma malignancy. Human Pygopus 2 (Pygo2) was recently discovered to be a component of the Wnt signaling pathway, which is required for β-catenin/Tcf-dependent transcription....

  • Knockdown of AGR2 induces cellular senescence in prostate cancer cells. Hu, Zhongyi; Gu, Yuanyuan; Han, Bo; Zhang, Jinsan; Li, Zunling; Tian, Keli; Young, Charles Y.F.; Yuan, Huiqing // Carcinogenesis;Jun2012, Vol. 33 Issue 6, p1178 

    Anterior-gradient 2 (AGR2), overexpressed in many tumors including prostate cancer (PCa), is implicated in stimulation of cell proliferation, adhesion, anti-apoptosis and cell cycle regulation. Here, a potential role of AGR2 in cellular senescence was investigated. We first observed that AGR2...

  • Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells. Lamb, Rebecca; Ablett, Matthew P.; Spence, Katherine; Landberg, Göran; Sims, Andrew H.; Clarke, Robert B. // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Introduction: Wnt signalling has been implicated in stem cell regulation however its role in breast cancer stem cell regulation remains unclear. Methods: We used a panel of normal and breast cancer cell lines to assess Wnt pathway gene and protein expression, and for the investigation of Wnt...

  • Functional properties of a new Wnt11 isoform expressed in colon carcinoma cell line HT29. Posvyatenko, A.; Kulikova, K.; Gnuchev, N.; Georgiev, G.; Kibardin, A.; Larin, S. // Molecular Biology;Feb2012, Vol. 46 Issue 1, p117 

    Colon carcinoma is a common type of neoplastic transformation. The mechanisms of its establishment and progression have been studied for several decades. Aberrant activation of canonical Wnt signaling is frequently observed in colon carcinoma cells. Moreover, expression of 'noncanonical' Wnt...

  • Bridge-1 is expressed in human breast carcinomas: silencing of Bridge-1 decreases Smad2, Smad3 and Smad4 expression in MCF-7 cells, a human breast cancer cell line. Banz-Jansen, Constanze; Münchow, Birte; Diedrich, Klaus; Finas, Dominique // Archives of Gynecology & Obstetrics;Dec2011, Vol. 284 Issue 6, p1543 

    Purpose: The aim of the study was to investigate the expression of Bridge-1 in human breast carcinomas, and to determine the in vitro regulation of Bridge-1 by activin A and the influence of Bridge-1 on activin A signaling in the human breast cancer cell line MCF-7. Method: Bridge-1 expression...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics