TITLE

Dose-Response Association of Uncontrolled Blood Pressure and Cardiovascular Disease Risk Factors with Hyperuricemia and Gout

AUTHOR(S)
Juraschek, Stephen P.; Kovell, Lara C.; Miller, Edgar R.; Gelber, Allan C.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: First-line therapy of hypertension includes diuretics, known to exert a multiplicative increase on the risk of gout. Detailed insight into the underlying prevalence of hyperuricemia and gout in persons with uncontrolled blood pressure (BP) and common comorbidities is informative to practitioners initiating antihypertensive agents. We quantify the prevalence of hyperuricemia and gout in persons with uncontrolled BP and additional cardiovascular disease (CVD) risk factors. Methods and Findings: We performed a cross-sectional study of non-institutionalized US adults, 18 years and older, using the National Health and Nutrition Examination Surveys in 1988–1994 and 1999–2010. Hyperuricemia was defined as serum uric acid >6.0 mg/dL in women; >7.0 mg/dL in men. Gout was ascertained by self-report of physician-diagnosed gout. Uncontrolled BP was based on measured systolic BP≥140 mmHg and diastolic BP≥90 mmHg. Additional CVD risk factors included obesity, reduced glomerular filtration rate, and dyslipidemia. The prevalence of hyperuricemia was 6–8% among healthy US adults, 10–15% among adults with uncontrolled BP, 22–25% with uncontrolled BP and one additional CVD risk factor, and 34–37% with uncontrolled BP and two additional CVD risk factors. Similarly, the prevalence of gout was successively greater, at 1–2%, 4–5%, 6–8%, and 8–12%, respectively, across these same health status categories. In 2007–2010, those with uncontrolled BP and 2 additional CVD risk factors compared to those without CVD risk factors had prevalence ratios of 4.5 (95% CI 3.5–5.6) and 4.5 (95% CI: 3.1–6.3) for hyperuricemia and gout respectively (P<0.01). Conclusions: Health care providers should be cognizant of the incrementally higher prevalence of hyperuricemia and gout among patients with uncontrolled BP and additional CVD risk factors. With one in three people affected by hyperuricemia among those with several CVD risk factors, physicians should consider their anti-hypertensive regimens carefully and potentially screen for hyperuricemia or gout.
ACCESSION #
87624709

 

Related Articles

  • Individualization of Antihypertensive Drug Treatment. MANCIA, GIUSEPPE; GRASSI, GUIDO // Diabetes Care;Aug2013 Supplement, Vol. 36 Issue S2, pS301 

    The article discusses factors that may help physicians toward individualized antihypertensive treatment approach. These drugs are classified to help physicians select the drug most suitable for treatment for the individual patient. It is noted that antihypertensive drugs to be used to control...

  • Measurement of Arterial Pressure Waves and Central Blood Pressure: Opportunities and Challenges. Kotchen, Theodore A. // American Journal of Hypertension;Sep2015, Vol. 28 Issue 9, p1075 

    The article presents the author's views on opportunities and challenges in measurement of arterial blood pressure. Topics discussed include predictions of cardiovascular risks through measurement of central blood pressure (CBP), impact of aging on arterial stiffness and variable effects produced...

  • Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships. Blumberg, Jeffrey B.; Chen, C. -Y. Oliver; Vita, Joseph A. // Nutrients;Dec2015, Vol. 7 Issue 12, p10032 

    Pure fruit juices provide nutritional value with evidence suggesting some of their benefits on biomarkers of cardiovascular disease risk may be derived from their constituent polyphenols, particularly flavonoids. However, few data from clinical trials are available on the dose-response...

  • Correlation of Central Blood Pressure to Hypertensive Target Organ Damages During Antihypertensive Treatment: The J-TOP Study. Motohiro Shimizu; Satoshi Hoshide; Joji Ishikawa; Yuichiro Yano; Kazuo Eguchi; Kazuomi Kario // American Journal of Hypertension;Aug2015, Vol. 28 Issue 8, p980 

    BACKGROUND Some previous studies have shown that central blood pressure (BP) is more closely related to cardiovascular risks than brachial BP. This study compared the correlations between asymptomatic organ damages and each of central BP, brachial clinic BP, and home BP during antihypertensive...

  • Is Isolated Nocturnal Hypertension A Reproducible Phenotype? Abdalla, Marwah; Goldsmith, Jeff; Muntner, Paul; Diaz, Keith M.; Reynolds, Kristi; Schwartz, Joseph E.; Shimbo, Daichi // American Journal of Hypertension;Jan2016, Vol. 29 Issue 1, p33 

    BACKGROUND: Isolated nocturnal hypertension (INH), defined as nocturnal without daytime hypertension on ambulatory blood pressure (BP) monitoring (ABPM), has been observed to be associated with an increased risk of cardiovascular disease (CVD) events and mortality. The aim of this study was to...

  • Framingham Ten-Year General Cardiovascular Disease Risk: Agreement between BMI-Based and Cholesterol-Based Estimates in a South Asian Convenience Sample. Jones, Charlotte A.; Ross, Leanne; Surani, Nadia; Dharamshi, Narissa; Karmali, Karima // PLoS ONE;Mar2015, Vol. 10 Issue 3, p1 

    The goal of this analysis was to determine the agreement between body mass index-based and cholesterol-based ten-year Framingham general cardiovascular disease risk scores among a convenience sample of 773 South Asian Canadian adults attending community-based screening clinics. Scores were...

  • EFICIENÅ¢A TERAPIEI CU INHIBITORI AI ENZIMEI DE CONVERSIE A ANGIOTENSINEI LA HIPERTENSIVII ARGEÅžENI. ŢÂNŢU, MONICA; CÎRLIG, VALENTIN; DOMNARIU, CARMEN DANIELA // Acta Medica Transilvanica;sep2013, Vol. 18 Issue 3, p94 

    Hypertension (High Blood Pressure) with its complications is a real and important public health problem even for the county of ArgeÅŸ. Angiotensin converting enzyme inhibitors (ACEI) appear as a pharmacological class recommended to be used in most clinical situations in which hypertension is...

  • Effects of Antihypertensive Drugs on Central Blood Pressure in Humans: A Preliminary Observation. Agnoletti, Davide; Zhang, Yi; Borghi, Claudio; Blacher, Jacques; Safar, Michel E. // American Journal of Hypertension;Aug2013, Vol. 26 Issue 8, p1045 

    BACKGROUND Central blood pressure (BP) is considered a better predictor of cardiovascular events than brachial BP. Modifications of central, beyond brachial BP, can be assessed by pressure amplification, a potential new cardiovascular risk factor. Comparison between drugs’ effect on...

  • Antihypertensive Medications Adherence Among Nigerian Hypertensive Subjects in a Specialist Clinic Compared to a General Outpatient Clinic. Akintunde, A. A.; Akintunde, T. S. // Annals of Medical & Health Sciences Research;May2015, Vol. 5 Issue 3, p173 

    Background: Poor adherence to antihypertensive medications has been linked with increased cardiovascular risk and mortality in many population. Africans have been shown to have a worse prognosis from hypertension, poorer blood pressure control, and increased risk of complications arising from...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics