Effect of Calcitriol on Bone Turnover and Osteocalcin in Recent-Onset Type 1 Diabetes

Napoli, Nicola; Strollo, Rocky; Pitocco, Dario; Bizzarri, Carla; Maddaloni, Ernesto; Maggi, Daria; Manfrini, Silvia; Schwartz, Ann; Pozzilli, Paolo
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined. Methodology/Principal Findings: We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1∶1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P<0.01) while no other metabolic parameters as HbA1c and C-peptide differed between gender. No significant correlations were found in relation to HbA1c, insulin requirement and C-peptide. At 1 year follow-up, no significant differences were observed between calcitriol and placebo groups for osteocalcin and β-CrossLaps. In the placebo group osteocalcin levels were unrelated with parameters of metabolic control, such as C-peptide, insulin requirement or HbA1c. Changes of C-peptide, insulin requirement and HbA1c were not related to osteocalcin levels. Conclusions: Supplementation with 0.25 µg calcitriol per day to patients with new-onset T1D does not affect circulating markers of bone turnover. OC levels were unrelated to β-cell function and other metabolic parameters suggesting that OC is ineffective to control pancreatic function in presence of aggressive autoimmune destruction.


Related Articles

  • Vitamin D supplementation in obese type 2 diabetes subjects in Ajman, UAE: a randomized controlled double-blinded clinical trial. Sadiya, A; Ahmed, S M; Carlsson, M; Tesfa, Y; George, M; Ali, S H; Siddieg, H H; Abusnana, S // European Journal of Clinical Nutrition;Jun2015, Vol. 69 Issue 6, p707 

    Objectives:To study the effect of Vitamin D3 supplementation on metabolic control in an obese type 2 diabetes Emirati population.Methods:This randomized double-blind clinical trial was conducted with 87 vitamin D-deficient obese, type 2 diabetic participants. The vitamin D-group (n=45) and the...

  • Clinical implications of vitamin D deficiency. Matyjaszek-Matuszek, Beata; Lenart-Lipińska, Monika; Woźniakowska, Ewa // Menopausal Review / Przeglad Menopauzalny;2015, Vol. 14 Issue 2, p75 

    Vitamin D deficiency is a common medical problem worldwide and its prevalence rises along with latitude, obesity, sedentary lifestyle, limited sunlight exposure and aging. A great body of evidence has shown that patients with vitamin D deficiency have increased cardiovascular risks and total...

  • AAP Doubles Recommended Vitamin D Intake in Children. ARMSTRONG, CARRIE // American Family Physician;7/15/2009, Vol. 80 Issue 2, p196 

    The article announces the move of the American Academy of Pediatrics (AAP) to double the recommended intake of vitamin D to 400 international units (IU) each day for infants, older children and teenagers. Vitamin D supplementation for infants who are breastfed are recommended in the first few...

  • Nutritional supplements could produce significant savings.  // PharmacoEconomics & Outcomes News;10/9/2004, Issue 463, p12 

    Discusses two research concerning the healthcare savings associated with the use of nutritional supplements. Annual treatment costs saved by the use of chromium and biotin supplementation by patients with type 2 diabetes; Estimated net savings in healthcare expenditure resulting from the use of...

  • Diet and behaviour: Are they linked? Seabert, Heidi // Adoption & Fostering;Spring2009, Vol. 33 Issue 1, p92 

    The article focuses on the relationship between children's diet and their behavior. Some studies found that certain food additives such as carmosine and the preservative sodium benzoate cause an increase in hyperactive behaviour. It recommends that children aged one to five take a supplement...

  • THE D LIST.  // Joe Weider's Muscle & Fitness;Jul2011, Vol. 72 Issue 7, p30 

    The article says that vitamin D deficiency may result in muscle and bone pain, and one should increase vitamin D intake by taking supplements and foods like salmon, yogurt, milk and eggs.

  • VITAMIN D CAUSES CANCER.  // Muscle & Performance;Apr2011, Vol. 3 Issue 4, p22 

    The article discusses the health benefits of taking daily vitamin D supplements including its efficacy for strengthening bones, reducing the risk of cancer, and increasing the probability of long life.

  • Vitamin D's benefits multiply.  // Chain Drug Review;7/18/2011, Vol. 33 Issue 12, p32 

    The article focuses on the growing benefits of vitamin D supplements in human nutrition.

  • A pilot randomized controlled trial of oral calcium and vitamin D supplementation using fortified laddoos in underprivileged Indian toddlers. Ekbote, V H; Khadilkar, A V; Chiplonkar, S A; Hanumante, N M; Khadilkar, V V; Mughal, M Z // European Journal of Clinical Nutrition;Apr2011, Vol. 65 Issue 4, p440 

    Background/Objectives:Low habitual dietary calcium intake and vitamin D deficiency are common among Indian children. Using 'laddoo', an Indian snack, as a vehicle for administering calcium and vitamin D supplements, a randomized double-blind controlled trial was conducted for 12 months to assess...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics