TITLE

CD133 Expression and the Prognosis of Colorectal Cancer: A Systematic Review and Meta-Analysis

AUTHOR(S)
Chen, Shicai; Song, Xinming; Chen, Zhihui; Li, Xinxin; Li, Mingzhe; Liu, Haiying; Li, Jianchang
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In this study, we aimed to evaluate the association between the expression of CD133 and clinicopathological features and the outcome of CRC patients by performing a meta-analysis. Methods: A comprehensive literature search for relevant studies published up to December 2012 was performed using PubMed, MEDLINE and ISI Web of Science. Only articles in which CD133 antigen was detected in situ localisation by immunohistochemical staining were included. This meta-analysis was done using RevMan 4.2 software. Results: We found that a total of 15 studies involving 810 CD133-high and 1487 CD133-low patients met the inclusion criteria for the analysis of 5-year overall survival (OS) rate. In a random-effects model, the results showed that CD133-high expression in colorectal cancer was an independent prognostic marker correlating with both OS rate (RR = 0.67, 95%CI 0.54–0.82, P<0.01) and disease free survival (DFS) rate (RR = 0.71, 95%CI 0.52–0.96, P = 0.03). CD133-high expression was also associated with more T3,4 tumor invasion, N positive and vascular invasion cases, corresponding to a risk difference of 1.12 (95%CI 1.01–1.23, P = 0.03), 1.31 (95%CI 1.06–1.63, P = 0.01) and 1.24 (95%CI 1.08–1.41, P<0.01), respectively. However, when types of histology, lymphatic invasion and distant metastasis were considered, CD133 overexpression was not significantly related with these clinicopathological parameters. Conclusion: Our meta-analysis results suggest that CD133 is an efficient prognostic factor in CRC. Higher CD133 expression is significantly associated with poorer clinical outcome and some clinicopathological factors such as T category, N category and vascular invasion in CRC patients.
ACCESSION #
87624552

 

Related Articles

  • Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature. Peng, Ling; Zhou, Yun; Wang, Yina; Mou, Haibo; Zhao, Qiong // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Background: Cyclooxygenase-2 (COX-2) is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Correlations between the expression of COX-2 with tumor growth and distant metastasis have become an issue; thus, attention has been paid to COX-2 as a prognostic factor....

  • Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis. Krieg, Andreas; Werner, Thomas A.; Verde, Pablo E.; Stoecklein, Nikolas H.; Knoefel, Wolfram T. // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin expression in CRC are heterogeneous. Thus, to clarify the prognostic relevance of survivin in patients with CRC and its association with...

  • Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis. Xia, Xiaochun; Yang, Baixia; Zhai, Xiaogang; Liu, Xiangyang; Shen, Kang; Wu, Zhijun; Cai, Jing // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Background:To date, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. The present meta-analysis summarizes the recent advances in the use of microRNA-21 (miR-21) in the assessment of...

  • S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer. Li-Yong Huang; Ye Xu; Guo-Xiang Cai; Zu-Qing Guan; Wei-Qi Sheng; Hong-Fen Lu; Li-Qi Xie; Hao-Jie Lu; San-Jun Cai // Annals of Gastroenterology & Hepatology;2011, Vol. 9 Issue 91, p69 

    AIM: To develop lymph node metastasis (LNM)-associated biomarkers for colorectal cancer (CRC) using quantitative proteome analysis. METHODS: Differences in protein expression between primary CRC with LNM (LNM CRC) and without LNM (non-LNM CRC) were assessed using methyl esterification stable...

  • S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer. Li-Yong Huang; Ye Xu; Guo-Xiang Cai; Zu-Qing Guan; Wei-Qi Sheng; Hong-Fen Lu; Li-Qi Xie; Hao-Jie Lu; San-Jun Cai // Annals of Gastroenterology & Hepatology;2011, Vol. 9 Issue 92, p69 

    AIM: To develop lymph node metastasis (LNM)-associated biomarkers for colorectal cancer (CRC) using quantitative proteome analysis. METHODS: Differences in protein expression between primary CRC with LNM (LNM CRC) and without LNM (non-LNM CRC) were assessed using methyl esterification stable...

  • Identification of Circulating MicroRNAs as Novel Potential Biomarkers for Gastric Cancer Detection: A Systematic Review and Meta-Analysis. Zhu, Xingya; Lv, Mengmeng; Wang, Hao; Guan, Wenxian // Digestive Diseases & Sciences;May2014, Vol. 59 Issue 5, p911 

    Background: Recent studies show that microRNAs (miRNAs) in serum or plasma can be stably detected and used as potential biomarkers in cancer diagnosis. Objectives: To systematically evaluate circulating miRNAs from numerous gastric cancer (GC) expression profiling studies and to determine miRNA...

  • Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. Chen, Jinhuang; Xia, Qinghua; Jiang, Bin; Chang, Weilong; Yuan, Wenzheng; Ma, Zhijun; Liu, Zhengyi; Shu, Xiaogang // PLoS ONE;12/18/2015, Vol. 10 Issue 12, p1 

    Objective: Many studies have indicated the prognostic and clinicopathological value of aldehyde dehydrogenase 1 (ALDH1) in colorectal cancer (CRC) patients still remains controversial. Thus we performed this study to clarify the relationship between high ALDH1 expression in CRC and its impact...

  • The Worse Prognosis of Right-Sided Compared with Left-Sided Colon Cancers: a Systematic Review and Meta-analysis. Yahagi, Masashi; Okabayashi, Koji; Hasegawa, Hirotoshi; Tsuruta, Masashi; Kitagawa, Yuko // Journal of Gastrointestinal Surgery;Mar2016, Vol. 20 Issue 3, p648 

    Background: Right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are of different embryological origins, and various differences exist between them. However, the survival difference has not been assessed. The aim of this meta-analysis was to quantify the prognostic...

  • Loss of vinculin and membrane-bound ß-catenin promotes metastasis and predicts poor prognosis in colorectal cancer. Ting Li; Hanqing Guo; Ying Song; Xiaodi Zhao; Yongquan Shi; Yuanyuan Lu; Sijun Hu; Yongzhan Nie; Daiming Fan; Kaichun Wu // Molecular Cancer;2014, Vol. 13 Issue 1, p62 

    Background Loss of cell-cell adhesion is important for the development of cancer invasion and metastasis. Vinculin, a key adhesion-related protein, can affect metastasis and prognosis in several tumours. Here, we determined the biological roles of vinculin in the metastasis of colorectal cancer...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics