Reduced Expression of ZDHHC2 Is Associated with Lymph Node Metastasis and Poor Prognosis in Gastric Adenocarcinoma

Yan, Shu-Mei; Tang, Jian-Jun; Huang, Chun-Yu; Xi, Shao-Yan; Huang, Ma-Yan; Liang, Jian-Zhong; Jiang, Yuan-Xue; Li, Yu-Hong; Zhou, Zhi-Wei; Ernberg, Ingemar; Wu, Qiu-Liang; Du, Zi-Ming
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Zinc finger, DHHC-type containing 2 (ZDHHC2), originally named as reduced expression associated with metastasis protein (REAM), has been proposed as a putative tumor/metastasis suppressor gene and is often aberrantly decreased in human cancers. However ZDHHC2 expression pattern and its clinical significance have not yet been investigated in gastric adenocarcinoma. Methodology/Principal Findings: Quantitative Real-Time PCR (qRT-PCR) and immunostaining were performed to detect ZDHHC2 expression in gastric adenocarcinoma, and then the correlation between ZDHHC2 expression and clinicpathologic parameters, and patient survival was analyzed. Compared to the adjacent normal tissues, ZDHHC2 expression was significantly reduced in gastric tumor tissues as shown by qRT-PCR and immunostaining. Low expression of ZDHHC2 was observed in 44.7% (211/472) of gastric adenocarcinoma patients, and was associated significantly with lymph node metastasis (p<0.001) and histological grade (p<0.001). Multivariate Cox regression analysis indicated that ZDHHC2 expression had a significant, independent predictive value for survival of gastric cancer patients (HR = 0.627, p = 0.001). Conclusions/Significance: Our data suggest that reduced ZDHHC2 expression is associated with lymph node metastasis and independently predicts an unfavorable prognosis in gastric adenocarcinoma patients.


Related Articles

  • miR-185 is an independent prognosis factor and suppresses tumor metastasis in gastric cancer. Tan, Zhiqin; Jiang, Hao; Wu, Youhua; Xie, Liming; Dai, Wenxiang; Tang, Hailin; Tang, Sanyuan // Molecular & Cellular Biochemistry;Jan2014, Vol. 386 Issue 1/2, p223 

    miR-185 has been identified as an important factor in several cancers such as breast cancer, ovarial cancer, and prostate cancer. However, its effect and prognostic value in gastric cancer are still poorly known. In this study, we found that the expression levels of miR-185 were strongly...

  • Comparative Evaluation of p53 Expression in Primary Tumors, Lymph Node Metastasis and Recurrent Tumors of Oral Cavity. Agarwal, Priyanka; Patil, Swati; Chaudhary, Minal; Agarwal, Puneet; Wadhwan, Vijay // Indian Journal of Stomatology;2014, Vol. 5 Issue 4, p117 

    Aim: The study was designed to evaluate correlation of p53 expression and disease progression. The present study was undert-aken with the purpose to evaluate and compare the p53 expression in 30 cases of primary tumor tissue and recurrent tumor tissue and tumor with metastasis and without...

  • Overexpression of focal adhesion kinase correlates with increased lymph node metastasis and poor prognosis in non-small-cell lung cancer. Ji, Hong-Fei; Pang, Da; Fu, Song-Bin; Jin, Yan; Yao, Lei; Qi, Ji-Ping; Bai, Jing // Journal of Cancer Research & Clinical Oncology;Mar2013, Vol. 139 Issue 3, p429 

    Background: The aim of this study was to investigate whether focal adhesion kinase (FAK) overexpression correlates with lymph node metastases and prognosis. Methods: The protein expression of FAK was investigated in 153 paraffin-embedded tissues by immunohistochemical analysis and then...

  • mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma. Baren, J P; Stewart, G D; Stokes, A; Gray, K; Pennington, C J; O'Neill, R; Deans, D A C; Paterson-Brown, S; Riddick, A C P; Edwards, D R; Fearon, K C H; Ross, J A; Skipworth, R J E // British Journal of Cancer;6/26/2012, Vol. 107 Issue 1, p143 

    Background:Degradation of the extracellular matrix is fundamental to tumour development, invasion and metastasis. Several protease families have been implicated in the development of a broad range of tumour types, including oesophago-gastric (OG) adenocarcinoma. The aim of this study was to...

  • Telomerase reverse transcriptase methylation predicts lymph node metastasis and prognosis in patients with gastric cancer. Yongxin Wu; Guichao Li; Dong He; Fengping Yang; Guang He; Lin He; Hui Zhang; Yun Deng; Ming Fan; Lijun Shen; Daizhan Zhou; Zhen Zhang // OncoTargets & Therapy;Jan2016, Vol. 9, p279 

    Purpose: Telomerase activity is associated with cellular immortalization and is present in most human tumors but absent in normal tissues. The activity of telomerase reverse transcriptase (TERT), a catalytic telomerase subunit, correlates with telomerase activity in tumors. The objective of this...

  • Lymph Node Metastasis, a Unique Independent Prognostic Factor in Early Gastric Cancer. Zhao, Bai-Wei; Chen, Yong-Ming; Jiang, Shan-Shan; chen, Yin-Bo; Zhou, Zhi-Wei; Li, Yuan-Fang // PLoS ONE;7/8/2015, Vol. 10 Issue 7, p1 

    Background: Lymph node metastasis (LNM) has been shown to be related to the prognosis of early gastric cancer (EGC). The choice of optimal treatment depends on an accurate pre-operative assessment of LNM status in EGC patients. However, in China, where EGC cases account for only a small part of...


    Background: Lymph node ratio and lymph node status are the most important prognostic factors in the patients with gastric carcinoma, and the depth of wall invasion, and the prognostic significance of the histological type is unclear. The extent of stomach resection in gastric cancer depends on...

  • Surgical treatment for isolated inguinal lymph node metastasis in lower rectal adenocarcinoma patients improves outcome. Adachi, Tomohiro; Hinoi, Takao; Egi, Hiroyuki; Ohdan, Hideki // International Journal of Colorectal Disease;Dec2013, Vol. 28 Issue 12, p1675 

    Purpose: No consensus has been formed on the optimal treatment strategy for the prognosis of patients with inguinal lymph node (ILN) metastasis from lower rectal adenocarcinoma. We, therefore, retrospectively analyzed outcomes of patients with ILN metastasis from lower rectal adenocarcinoma....

  • Clinical and pathological features of five-year survivors after pancreatectomy for pancreatic adenocarcinoma. Kenjiro Kimura; Ryosuke Amano; Bunzo Nakata; Sadaaki Yamazoe; Keiichiro Hirata; Akihiro Murata; Kotaro Miura; Kohei Nishio; Toshiki Hirakawa; Masaichi Ohira; Kosei Hirakawa // World Journal of Surgical Oncology;2014, Vol. 12 Issue 1, p1 

    Background Clinical factors determining short-term survival after pancreatectomy have been well studied, but factors predicting long-term survival with curative resection are poorly understood in pancreatic carcinoma. Our objective was to identify clinical and pathological features of five-year...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics