TITLE

Cognitive Performance as a Zeitgeber: Cognitive Oscillators and Cholinergic Modulation of the SCN Entrain Circadian Rhythms

AUTHOR(S)
Gritton, Howard J.; Stasiak, Ashley M.; Sarter, Martin; Lee, Theresa M.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals that can synchronize or entrain to environmental cues. Although light exerts powerful influences on SCN output, other non-photic stimuli can modulate the SCN as well. We recently demonstrated that daily performance of a cognitive task requiring sustained periods of attentional effort that relies upon basal forebrain (BF) cholinergic activity dramatically alters circadian rhythms in rats. In particular, normally nocturnal rats adopt a robust diurnal activity pattern that persists for several days in the absence of cognitive training. Although anatomical and pharmacological data from non-performing animals support a relationship between cholinergic signaling and circadian rhythms, little is known about how endogenous cholinergic signaling influences SCN function in behaving animals. Here we report that BF cholinergic projections to the SCN provide the principal signal allowing for the expression of cognitive entrainment in light-phase trained animals. We also reveal that oscillator(s) outside of the SCN drive cognitive entrainment as daily timed cognitive training robustly entrains SCN-lesioned arrhythmic animals. Ablation of the SCN, however, resulted in significant impairments in task acquisition, indicating that SCN-mediated timekeeping benefits new learning and cognitive performance. Taken together, we conclude that cognition entrains non-photic oscillators, and cholinergic signaling to the SCN serves as a temporal timestamp attenuating SCN photic-driven rhythms, thereby permitting cognitive demands to modulate behavior.
ACCESSION #
87624385

 

Related Articles

  • An Approach for Identifying Brainstem Dopaminergic Pathways Using Resting State Functional MRI. Vytlacil, Jason; Kayser, Andrew; Miyakawa, Asako; D’Esposito, Mark // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal...

  • Working Memory and Its Relation to Deterministic Sequence Learning. Martini, Markus; Furtner, Marco R.; Sachse, Pierre // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Is there a relation between working memory (WM) and incidental sequence learning? Nearly all of the earlier investigations in the role of WM capacity (WMC) in sequence learning suggest no correlations in incidental learning conditions. However, the theoretical view of WM and operationalization...

  • Insights from neuropsychology: pinpointing the role of the posterior parietal cortex in episodic and working memory. Berryhill, Marian E. // Frontiers in Integrative Neuroscience;Jun2012, Vol. 6, p1 

    The role of posterior parietal cortex (PPC) in various forms of memory is a current topic of interest in the broader field of cognitive neuroscience. This large cortical region has been linked with a wide range of mnemonic functions affecting each stage of memory processing: encoding,...

  • Consolidation Differentially Modulates Schema Effects on Memory for Items and Associations. van Kesteren, Marlieke T. R.; Rijpkema, Mark; Ruiter, Dirk J.; Fernández, Guillén // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Newly learned information that is congruent with a preexisting schema is often better remembered than information that is incongruent. This schema effect on memory has previously been associated to more efficient encoding and consolidation mechanisms. However, this effect is not always...

  • Neural Dynamics of Attentional Cross-Modality Control Rabinovich, Mikhail; Tristan, Irma; Varona, Pablo // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    Attentional networks that integrate many cortical and subcortical elements dynamically control mental processes to focus on specific events and make a decision. The resources of attentional processing are finite. Nevertheless, we often face situations in which it is necessary to simultaneously...

  • Mathematical disabilities: Reflections on cognitive, neuropsychological, and genetic components. Geary, David C. // Learning & Individual Differences;Apr2010, Vol. 20 Issue 2, p130 

    Abstract: The collection of articles in this special issue and related studies over the past decade provides a fine example of the substantial progress that has been made in our understanding and remediation of mathematical learning disabilities and difficulties since 1993 (Geary, 1993). The...

  • Memory Dysfunction. Budson, Andrew E.; Price, Bruce H. // New England Journal of Medicine;2/17/2005, Vol. 352 Issue 7, p692 

    Presents the latest concepts about memory dysfunction. New classifications of memory which result from neuropsychological studies of patients; Understanding that memory is a collection of mental abilities that depend on several systems within the brain; Discussion of the four memory systems that...

  • Executive frontal functions. Fuster, Joaquín M. // Experimental Brain Research;Jul2000, Vol. 133 Issue 1, p66 

    This chapter presents a conceptual model of the representational and executive functions of the cortex of the frontal lobe derived from empirical evidence obtained principally in the monkey. According to this model, the neuronal networks of the frontal lobe that represent motor or executive...

  • New Cognitive Robotics Lab Tests Theories of Human Thought.  // Journal of Artificial Intelligence;2011, Vol. 4 Issue 2, p167 

    In a new Cognitive Robotics Lab, students at Rensselaer are exploring how human thought outwits brute force computing in the real world? The lab's 20 programmable robots allow students to test the real-world performance of computer models that mimic human thought.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics