Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View

Yang, Jin; Yang, Zongxing; Lv, Hangjun; Lou, Yi; Wang, Juan; Wu, Nanping
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency. Given that the most overlapping characteristics found between HIV-1 LTNP and latency, detailed analysis of the difference would disclose the essentials of latency. In this study, microarray data from our previous study was combined with HIV-1 latency and LTNP data obtained from NCBI GEO database. Principal variance component analysis and hierarchical clustering verified the removal of batch effect across platform. The analysis revealed a total of 456 differential expressed genes with >2-fold change and B-statistic >0. Bayesian inference was used to reconstitute the transcriptional network of HIV-1 latency or LTNP, respectively. Gene regulation was reprogrammed under different disease condition. By network interference, KPNA2 and ATP5G3 were identified as the hubs in latency network which mediate nuclear export and RNA processing. These data offer comparative insights into HIV-1 latency, which will facilitate the understanding of the genetic basis of HIV-1 latency in vivo and serve as a clue for future treatment dealing with key targets in HIV-1 latency.


Related Articles

  • Carlavirus. Foster, Gary D. // Springer Index of Viruses;2002, p1224 

    The article offers information on Carlavirus. The virus' genome and replication strategy is described. A chronological list of the virus' history of discovery and research is presented as well. Its genus members are also listed, which include the species Carnation latent virus and American hop...

  • Antibodies to the E4, E6, and E7 Proteins of Human Papillomavirus (HPV) Type 16 in Patients with HPV-Associated Diseases and in the Normal Population. Müller, Martin; Viscidi, Raphael P.; Ulken, Vera; Bavinck, Jan Nico Bouwes; Hill, Peter M.; Fisher, Susan G.; Reid, Richard; Munoz, Nubia; Schneider, Achim; Shah, Keerti V.; Gissmann, Lutz // Journal of Investigative Dermatology;Jan1995, Vol. 104 Issue 1, p138 

    In a cross-sectional study, titers of antibodies to the E4 and E7 proteins of human papillomavirus (HPV) type 16 were measured by peptide-based enzyme-linked immunosorbent assay in 1707 sera. Sera were obtained from healthy individuals (ages 1 to 95 years), from patients with HPV-associated...

  • Virus Proteins Prevent Cell Suicide Long Enough to Establish Latent Infection. Gross, Liza // PLoS Biology;Dec2005, Vol. 3 Issue 12, pe430 

    The article presents information about the role of viral protein in latent infection. A virus cannot reproduce without the help from cell which it ultimately may destroy. A virus slips inside the cell after attaching to the cell membrane and then co-opts its transcription and replication...

  • Latent Viral Infection.  // Encyclopedic Reference of Cancer;2001, p491 

    A definition of the term "latent viral infection" is presented. This term refers to a condition wherein the virus persists in the infected host throughout the latter's life in a non-replicative state. The virus replicates productively upon its reactivation and may cause recurrent infections upon...

  • SUMMARY REPORT: TREATING HIV/AIDS. Rabah, Raida // Ethnicity & Disease;Summer2007 Supplement 3, Vol. 17, pS3100 

    The article discusses some advances in treating HIV/AIDS. It is estimated that only eight percent of the four million infected people in Africa are receiving antiretrovirals. Drugs that target different stages and steps in viral replications have been developed and are best used in combinations...

  • Amount of AIDS Virus in Genital Secreations Predicts Risk of Heterosexual Transmission.  // Trends in Medical Research;2011, Vol. 6 Issue 4, p316 

    No abstract available.

  • Gene- and Protein-Delivered Zinc Finger–Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus. Mino, Takashi; Mori, Tomoaki; Aoyama, Yasuhiro; Sera, Takashi // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Previously, we reported that artificial zinc-finger proteins (AZPs) inhibited virus DNA replication in planta and in mammalian cells by blocking binding of a viral replication protein to its replication origin. However, the replication mechanisms of viruses of interest need to be disentangled...

  • Effects of HCV on Basal and Tat-Induced HIV LTR Activation. Sengupta, Satarupa; Powell, Eleanor; Kong, Ling; Blackard, Jason T. // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Hepatitis C virus (HCV) co-infection occurs in ∼30–40% of the HIV-infected population in the US. While a significant body of research suggests an adverse effect of HIV on HCV replication and disease progression, the impact of HCV on HIV infection has not been well studied. Increasing...

  • Inferring Host Gene Subnetworks Involved in Viral Replication. Chasman, Deborah; Gancarz, Brandi; Hao, Linhui; Ferris, Michael; Ahlquist, Paul; Craven, Mark // PLoS Computational Biology;May2014, Vol. 10 Issue 5, p1 

    Systematic, genome-wide loss-of-function experiments can be used to identify host factors that directly or indirectly facilitate or inhibit the replication of a virus in a host cell. We present an approach that combines an integer linear program and a diffusion kernel method to infer the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics