Association of Dyslipidemia with Renal Outcomes in Chronic Kidney Disease

Chen, Szu-Chia; Hung, Chi-Chih; Kuo, Mei-Chuan; Lee, Jia-Jung; Chiu, Yi-Wen; Chang, Jer-Ming; Hwang, Shang-Jyh; Chen, Hung-Chun
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia with renal outcomes in patients with moderate to advanced CKD remains controversial. Hence, our objective is to determine whether dyslipidemia is independently associated with rapid renal progression and progression to renal replacement therapy (RRT) in CKD patients. The study analyzed the association between lipid profile, RRT, and rapid renal progression (estimated glomerular filtration rate [eGFR] slope <−6 ml/min/1.73 m2/yr) in 3303 patients with stages 3 to 5 CKD. During a median 2.8-year follow-up, 1080 (32.3%) participants commenced RRT and 841 (25.5%) had rapid renal progression. In the adjusted models, the lowest quintile (hazard ratios [HR], 1.23; 95% confidence interval [CI], 1.01 to 1.49) and the highest two quintiles of total cholesterol (HR, 1.25; 95% CI, 1.02 to 1.52 and HR, 1.35; 95% CI, 1.11 to 1.65 respectively) increased risks for RRT (vs. quintile 2). Besides, the highest quintile of total cholesterol was independently associated with rapid renal progression (odds ratio, 1.36; 95% CI, 1.01 to 1.83). Our study demonstrated that certain levels of dyslipidemia were independently associated with RRT and rapid renal progression in CKD stage 3–5. Assessment of lipid profile may help identify high risk groups with adverse renal outcomes.


Related Articles

  • Prevalence and Predictors of Post-traumatic Stress Disorder in Adults One Year Following Traumatic Brain Injury: A Population-based Study. Barker-Collo, Suzanne; Theadom, Alice; Ameratunga, Shanthi; Jones, Kelly; Jones, Amy; Starkey, Nicola; Feigin, Valery L. // Brain Impairment;Dec2013, Vol. 14 Issue 3, p425 

    Objective: Experiencing a traumatic brain injury (TBI) may increase the risk of post-traumatic stress disorder (PTSD); however, this has not been examined in a population-based context. This study examined prevalence and predictors (demographic and injury related) of PTSD 1 year after TBI in a...

  • Change in the estimated glomerular filtration rate over time and risk of all-cause mortality. Turin, Tanvir C; Coresh, Josef; Tonelli, Marcello; Stevens, Paul E; de Jong, Paul E; Farmer, Christopher K T; Matsushita, Kunihiro; Hemmelgarn, Brenda R // Kidney International;Apr2013, Vol. 83 Issue 4, p684 

    Using a community-based cohort we studied the association between changes in the estimated glomerular filtration rate (eGFR) over time and the risk of all-cause mortality. We identified 529,312 adults who had at least three outpatient eGFR measurements over a 4-year period from a provincial...

  • Plasma beta-2 microglobulin is associated with cardiovascular disease in uremic patients. Liabeuf, Sophie; Lenglet, Aurélie; Desjardins, Lucie; Neirynck, Nathalie; Glorieux, Griet; Lemke, Horst-Dieter; Vanholder, Raymond; Diouf, Momar; Choukroun, Gabriel; Massy, Ziad A // Kidney International;Dec2012, Vol. 82 Issue 12, p1297 

    Since beta-2 microglobulin (B2M) is a surrogate marker for middle molecular weight uremic toxins and the major protein component in dialysis-related amyloidosis, it has been frequently studied in dialysis patients. It is not known, however, whether B2M has an impact in patients with chronic...

  • Transumbilical laparoendoscopic single-site pyeloplasty in infants and children: initial experience and short-term outcome. Zhou, Huixia; Sun, Ning; Zhang, Xu; Xie, Huawei; Ma, Lifei; Shen, Zhou; Zhou, Xiaoguang; Tao, Tian // Pediatric Surgery International;Mar2012, Vol. 28 Issue 3, p321 

    Background: Scar-free abdominal wall surgery is a research hotspot in recent years. This study presented surgical skills of transumbilical laparoendoscopic single-site pyeloplasty (LESS-P) for pediatric patients with ureteropelvic junction obstruction (UPJO) and its clinical application....

  • Poor renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and normal renal function at diagnosis. Hanaoka, Hironari; Ota, Yuichiro; Takeuchi, Tsutomu; Kuwana, Masataka // Clinical Rheumatology;Feb2016, Vol. 35 Issue 2, p495 

    The aim of this study is to investigate the renal outcomes of anti-neutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis in patients with normal estimated glomerular filtration rate (eGFR) at diagnosis. Twenty-seven patients with biopsy-proven ANCA-associated crescentic...

  • Conversion from calcineurin inhibitors to sirolimus of recipients with chronic kidney graft disease grade III for a period 2003-2011. Ignjatović, Ljiljana; Hrvačević, Rajko; Jovanović, Dragan; Kovačević, Zoran; Vavić, Neven; Rabrenović, Violeta; Tomić, Aleksandar; Aleksić, Predrag; Drašković-Pavlović, Biljana; Dujić, Aleksandar; Karan, Željko; Maksić, Djoko // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Sep2013, Vol. 70 Issue 9, p848 

    Background/Aim. Tremendous breakthrough in solid organ transplantation was made with the introduction of calcineurin inhibitors (CNI). At the same time, they are potentially nephrotoxic drugs with influence on onset and progression of renal graft failure. The aim of this study was to evaluate...

  • Impact of left ventricular dyssynchrony by phase analysis on cardiovascular outcomes in patients with end-stage renal disease. AlJaroudi, Wael; Aggarwal, Himanshu; Venkataraman, Rajesh; Heo, Jaekyeong; Iskandrian, Ami; Hage, Fadi // Journal of Nuclear Cardiology;Nov2010, Vol. 17 Issue 6, p1058 

    Background: Cardiovascular disease is the leading cause of mortality in patients with end-stage renal disease (ESRD). While left ventricular (LV) perfusion pattern and ejection fraction (EF) are important determinant of outcome, the prognostic importance of LV dyssynchrony, which can also be...

  • Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts. Gansevoort, Ron T.; Matsushita, Kunihiro; van der Velde, Marije; Astor, Brad C.; Woodward, Mark; Levey, Andrew S.; Jong, Paul E. de; Coresh, Josef; de Jong, Paul E.; El-Nahas, Meguid; Eckardt, Kai-Uwe; Kasiske, Bertram L.; Ninomiya, Toshiharu; Chalmers, John; MacMahon, Stephen; Tonelli, Marcello; Hemmelgarn, Brenda; Wang, Yaping; Atkins, Robert C.; Polkinghorne, Kevan R. // Kidney International;Jul2011, Vol. 80 Issue 1, p93 

    Both a low estimated glomerular filtration rate (eGFR) and albuminuria are known risk factors for end-stage renal disease (ESRD). To determine their joint contribution to ESRD and other kidney outcomes, we performed a meta-analysis of nine general population cohorts with 845,125 participants and...

  • Defining Incident Chronic Kidney Disease in the Research Setting: The ARIC Study. Lori D. Bash; Josef Coresh; Anna Köttgen; Rulan S. Parekh; Tibor Fulop; Yaping Wang; Brad C. Astor // American Journal of Epidemiology;Aug2009, Vol. 170 Issue 4, p414 

    Deaths of participants and losses to follow-up pose challenges for defining outcomes in epidemiologic studies. The authors compared several definitions of incident chronic kidney disease (CKD) in terms of incidence, agreement, and risk factor associations. They used data from 14,873 participants...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics