Exercise Attenuates Renal Dysfunction with Preservation of Myocardial Function in Chronic Kidney Disease

Luiz, Rafael da Silva; Silva, Kleiton Augusto Santos; Rampaso, Rodolfo Rosseto; Antônio, Ednei Luiz; Montemor, Jairo; Bocalini, Danilo Sales; dos Santos, Leonardo; Moura, Luiz; Tucci, Paulo José Ferreira; de Abreu, Nayda Parísio; Schor, Nestor
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Previous studies have suggested that exercise improves renal and cardiac functions in patients with chronic kidney disease. The aim of this study was to evaluate the effects of long-term aerobic swimming exercise with overload on renal and cardiac function in rats with 5/6 nefrectomy (5/6Nx). Eight Wistar rats were placed into 4 groups: Control (C), Control+Exercise (E), Sedentary 5/6Nx (NxS) and 5/6Nx+Exercise (NxE). The rats were subjected to swimming exercise sessions with overload for 30 min five days per week for five weeks. Exercise reduced the effect of 5/6Nx on creatinine clearance compared to the NxS group. In addition, exercise minimized the increase in mean proteinuria compared to the NxS group (96.9±10.0 vs. 51.4±9.9 mg/24 h; p<0.05). Blood pressure was higher in the NxS and NxE groups compared to the C and E groups (216±4 and 178±3 vs. 123±2 and 124±2 mm Hg, p<0.05). In the 200 glomeruli that were evaluated, the NxS group had a higher sclerosis index than did the NxE group (16% vs. 2%, p<0.05). Echocardiography demonstrated a higher anterior wall of the left ventricle (LV) in diastole in the NxS group compared with the C, E and NxE groups. The NxS group also had a higher LV posterior wall in diastole and systole compared with the E group. The developed isometric tension in Lmax of the heart papillary muscle was lower in the NxS group compared with the C, E and NxE groups. These results suggested that exercise in 5/6Nx animals might reduce the progression of renal disease and lessen the cardiovascular impact of a reduction in renal mass.


Related Articles

  • The effects of the number of sessions of continuous and intermittent aerobic training in a week on markers of healthy heart in menopause Wistars rats. Roshan, Valiollah Dabidy; Jolazadeh, Tala // Journal of Mazandaran University of Medical Sciences (JMUMS);Feb/Mar2010, Vol. 20 Issue 74, p43 

    Background and purpose: The purpose of the present study was to determine the effects of three and five sessions of continuous and intermittent aerobic training in a week on some markers of healthy heart (high sensitive C- reactive protein [HS-CRP], LDL-C and HDL-C) in female Wistars rats of...

  • Renal metabolism of glutamine in rats with acute renal failure. Anderson, Norma McFarlane; Hortelano, Paloma; Alleyne, Goerge A. O. // Kidney International;Dec1982, Vol. 22 Issue 6, p640 

    Acute renal failure induced by glycerol results in increased metabolism of glutamine by renal cortical slices of rats 16 and 36 hr after onset, and there is also increased glutamine uptake by the kidney in vivo. Metabolism of glutamine and glutamate to glucose is inhibited. At 8 days after onset...

  • Role of 5-HT Serotonin Receptor Agonist in the Regulation of Pumping Function of the Heart. Abzalov, R.; Valeev, A.; Abzalov, N.; Gulyakov, A. // Bulletin of Experimental Biology & Medicine;Jul2015, Vol. 159 Issue 3, p302 

    The effect of α-methyl-5-hydroxytryptamine maleate, an agonist of 5-HT serotonin receptors, on the pumping function of the heart was examined in rats with forced motor behavior. At rest, swim-trained rats demonstrated lower HR and greater stroke volume and cardiac output than untrained rats....

  • P765 Diabetic cardiomyopathy: a comparative investigation in diabetic rat models. Matyas, C; Korkmaz, S; Olah, A; Nemeth, BT; Hidi, L; Birtalan, E; Torok, M; Merkely, B; Szabo, G; Radovits, T // Cardiovascular Research;Jul2014, Vol. 103 Issue suppl_1, pS140 

    Purpose: Diabetic cardiomyopathy, a cardiac manifestation of diabetes mellitus (DM), is characterised by specific structural, molecular and functional alterations of the myocardium. Upon this concept we investigated whether type-1 or type-2 diabetes lead to different alterations in cardiac...

  • Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD). Zafar, Iram; Belibi, Franck A.; He, Zhibin; Edelstein, Charles L. // Nephrology Dialysis Transplantation;Aug2009, Vol. 24 Issue 8, p2349 

    Background. Short-term studies have demonstrated that rapamycin or everolimus treatment decreases cyst formation and improves renal function in animal models of polycystic kidney disease (PKD). Autosomal dominant polycystic kidney disease (ADPKD) patients would likely require life-long treatment...

  • Effect of Adaptation to Graduated Physical Exercises on the Function of the Rat Myocardium. S. Talanov; V. Buryi; V. Sagach // Neurophysiology;Feb2009, Vol. 41 Issue 1, p37 

    On isolated hearts obtained from control rats and rats subjected to regular physical exercises (forced swimming) during 6 weeks, we studied the contractile activity of the heart, resistance of the myocardium to ischemia/reperfusion-induced injuries, as well as the dependence of the developed and...

  • Hepatocellular transport and gastrointestinal absorption of lanthanum in chronic renal failure. Bervoets, An R. J.; Behets, Geert J.; Schryvers, Dominick; Roels, Frank; Zhang Yang; Verberckmoes, Steven C.; Damment, Stephen J. P.; Dauwe, Simonne; Mubiana, Valentine K.; Blust, Ronny; De Broe, Marc E.; D'Haese, Patrick C. // Kidney International;Feb2009, Vol. 75 Issue 4, p389 

    Lanthanum carbonate is a new phosphate binder that is poorly absorbed from the gastrointestinal tract and eliminated largely by the liver. After oral treatment, we and others had noticed 2–3 fold higher lanthanum levels in the livers of rats with chronic renal failure compared to rats...

  • Effect of acute potassium load on reabsorption in Henle's loop in chronic renal failure in the rat. Milanes, Carmen L.; Jamison, Rex L. // Kidney International;Jun1985, Vol. 27 Issue 6, p919 

    To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed anti branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied...

  • Phosphate depletion arrests progression of chronic renal failure independent of protein intake. Lumlertgul, Dusit; Burke, Thomas J.; Gillum, David M.; Alfrey, Allen C.; Harris, David C.; Hammond, William S.; Schrier, Robert W. // Kidney International;Mar1986, Vol. 29 Issue 3, p658 

    Phosphate depletion arrests progression of chronic renal failure independent of protein intake. Following 5⁄6 nephrectomy, 18 rats were fed a normal diet. After 30 days, serum creatinine (SCr), urine protein excretion and urine volume were increased compared to pre-nephrectomy (0.27 ±...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics