Re-Emergence of Dengue Virus Type 3 in Canton, China, 2009–2010, Associated with Multiple Introductions through Different Geographical Routes

Liang, Huiying; Luo, Lei; Yang, Zhicong; Di, Biao; Bai, Zhijun; He, Peng; Jing, Qinlong; Zheng, Xueli
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Endemic dengue virus type 3 (DENV-3) infections have not been reported in Canton, China, since 1980. In March 2009, DENV-3 was isolated for the second time, occurring about 30 years after the previous circulation. In August, 3 other cases emerged. One much larger outbreak occurred again in 2010. To address the origin and particularly to determine whether the outbreaks were caused by the same viral genotype, we investigated the epidemiological and molecular characteristics of the introduction, spread and genetic microevolution of DENV-3 involved. Methodology/Principal Findings: Three imported cases (index-1,2,3) separately traveled back from Vietnam, India and Tanzania, resulted in 1, 3 and 60 secondary autochthonous cases, respectively. In autochthonous cases, 64.6% positive in IgM anti-DENV and 18.6% in IgG from a total of 48 submitted serum samples, accompanied by 7 DENV-3 isolates. With 99.8%, 99.7%, and 100% envelope gene nucleotidic identity, 09/GZ/1081 from index-1 and endemic strain (09/GZ/1483) belonged to genotype V; 09/GZ/10616 from index-2 and endemic strains (09/GZ/11144 and 09/GZ/11194) belonged to genotype III Clade-A; and 10/GZ/4898 from index-3 and all four 2010 endemic DENV-3 strains belonged to genotype III Clade-B, respectively. Conclusions/Significance: Both epidemiological and phylogenetic analyses showed that the 2010 outbreak of dengue was not a reemergence of the 2009 strain. Introductions of different genotypes following more than one route were important contributory factors for the 2009–2010 dengue epidemics/outbreaks in Canton. These findings underscore the importance of early detection and case management of imported case in preventing large-scale dengue epidemics among indigenous peoples of Canton.


Related Articles

  • Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation. Samsa, Marcelo M.; Mondotte, Juan A.; Iglesias, Nestor G.; Assunção-Miranda, Iranaia; Barbosa-Lima, Giselle; Da Poian, Andrea T.; Bozza, Patricia T.; Gamarnik, Andrea V. // PLoS Pathogens;Oct2009, Vol. 5 Issue 10, p1 

    Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals. In recent years, a great deal has been learned about the...

  • DENGUE: Past, Present and Future. CARRINGTON, CHRISTINE // UWI Today;Apr2013, p8 

    The article focuses on the increasing number of dengue cases in the Americas. It notes that people in the region experience the debilitating and the life-threatening effects of dengue virus infection, suggesting that the disease costs the Caribbean nearly $321 million every year. Several studies...

  • Zika in Yap. Deresinski, Stan // Travel Medicine Advisor;Oct2007, Vol. 17 Issue 10, p47 

    An outbreak of dengue-like illness that began in May, 2007, on Yap, one of the Carolina islands of the Federated States of Micronesia, proved to be due to Zika virus. As of early August, 99 confirmed and 54 probable cases had been identified, with the most recent case dating from July 17th....

  • Final characterization of and lessons leaned from the dengue 3 epidemic in Cuba, 2001-2002. Guzmán, María G.; Peláez, Otto; Kourí, Gustavo; Quintana, Ibrahim; Vázquez, Susana; Pentón, Macdelín; Ávila, Luis Carlos // Revista Panamericana de Salud Publica;Abr2006, Vol. 19 Issue 4, p282 

    Over the past 10 years, the American Region has witnessed the reintroduction and dissemination of dengue virus serotype 3. In this paper we describe the main clinical and epidemiologic features of the dengue 3 epidemic that broke out in Cuba between June 2001 and March 2002, as well as the...

  • Dengue Virus 3 Genotype 1 Associated with Dengue Fever and Dengue Hemorrhagic Fever, Brazil. Figueiredo, Leandra Barcelos; Cecílio, Alzira Batista; Ferreira, Gustavo Portela; Drumond, Betânia Paiva; De Oliveira, Jaquelline Germano; Bonjardim, Cláudio Antônio; Ferreira, Paulo César Peregrino; Kroon, Erna Geessien // Emerging Infectious Diseases;Feb2008, Vol. 14 Issue 2, p314 

    Dengue serotype 3 viruses were isolated from patients in Brazil from 2002 through 2004. On the basis of phylogenetic analyses, these isolates were assigned genotype 1. This genotype had never been reported in South America before. Its appearance indicates a major risk factor for dengue epidemics...

  • Dengue Virus Surveillance for Early Warning, Singapore. Kim-Sung Lee; Yee-Ling Lai; Lo, Sharon; Barkham, Timothy; Aw, Pauline; Peng-Lim Ooi; Ji-Choong Tai; Hibberd, Martin; Johansson, Patrik; Seow-Poh Khoo; Lee-Ching Ng // Emerging Infectious Diseases;May2010, Vol. 16 Issue 5, p847 

    In Singapore, after a major outbreak of dengue in 2005, another outbreak occurred in 2007. Laboratory-based surveillance detected a switch from dengue virus serotype 1 (DENV-1) to DENV-2. Phylogenetic analysis showed a clade replacement within DENV-2 cosmopolitan genotype, which accompanied the...

  • Co-Circulation of Dengue Virus Type 3 Genotypes in Vientiane Capital, Lao PDR. Lao, Malayvanh; Caro, Valérie; Thiberge, Jean-Michel; Bounmany, Phaitong; Vongpayloth, Khamsing; Buchy, Philippe; Duong, Veasna; Vanhlasy, Chansamone; Hospied, Jean-Marie; Thongsna, Manichanh; Choumlivong, Khamla; Vongkhamchanh, Phonesavanh; Oudavong, Bounleua; Brey, Paul T.; Grandadam, Marc // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    During the 2012 epidemic of dengue in Vientiane capital, Lao PDR, a major serotype switch from dengue 1 to 3 was observed. A molecular epidemiology study demonstrated that dengue 3 remained the predominant serotype in 2013, but also revealed the co-circulation of two genotypes, supporting the...

  • Cities spawn epidemic dengue viruses. Gubler, Duane J. // Nature Medicine;Feb2004, Vol. 10 Issue 2, p129 

    This article reports about the major countrywide and regional epidemics of dengue and dengue hemorrhagic fever (DHF), that occurs in Southeast Asia every three to five years. Dengue viruses are the most important arboviruses causing human disease, with 2.5-3 billion people living in areas of...

  • First genome sequence of St. Louis encephalitis virus (SLEV) isolated from a human in Brazil. Vedovello, Danila; Drumond, Betânia; Marques, Rafael; Ullmann, Leila; Fávaro, Eliane; Terzian, Ana; Figueiredo, Luiz; Teixeira, Mauro; Junior, João; Nogueira, Maurício // Archives of Virology;May2015, Vol. 160 Issue 5, p1189 

    St. Louis encephalitis virus (SLEV), a member of the family Flaviviridae, genus Flavivirus, is a causative agent of encephalitis in the Americas. In Brazil, sporadic cases of SLEV infection have been reported since 1953, but the first outbreak of SLEV in Brazil was identified only in 2007,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics