TITLE

Effect of Gum Arabic on Oxidative Stress and Inflammation in Adenine–Induced Chronic Renal Failure in Rats

AUTHOR(S)
Ali, Badreldin H.; Al-Husseni, Isehaq; Beegam, Sumyia; Al-Shukaili, Ahmed; Nemmar, Abderrahim; Schierling, Simone; Queisser, Nina; Schupp, Nicole
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inflammation and oxidative stress are known to be involved in the pathogenesis of chronic kidney disease in humans, and in chronic renal failure (CRF) in rats. The aim of this work was to study the role of inflammation and oxidative stress in adenine-induced CRF and the effect thereon of the purported nephroprotective agent gum arabic (GA). Rats were divided into four groups and treated for 4 weeks as follows: control, adenine in feed (0.75%, w/w), GA in drinking water (15%, w/v) and adenine+GA, as before. Urine, blood and kidneys were collected from the rats at the end of the treatment for analysis of conventional renal function tests (plasma creatinine and urea concentration). In addition, the concentrations of the pro-inflammatory cytokine TNF-α and the oxidative stress markers glutathione and superoxide dismutase, renal apoptosis, superoxide formation and DNA double strand break frequency, detected by immunohistochemistry for γ-H2AX, were measured. Adenine significantly increased the concentrations of urea and creatinine in plasma, significantly decreased the creatinine clearance and induced significant increases in the concentration of the measured inflammatory mediators. Further, it caused oxidative stress and DNA damage. Treatment with GA significantly ameliorated these actions. The mechanism of the reported salutary effect of GA in adenine-induced CRF is associated with mitigation of the adenine-induced inflammation and generation of free radicals.
ACCESSION #
87623651

 

Related Articles

  • Comparative Efficacy of Three Brands of Gum Acacia on Adenine- Induced Chronic Renal Failure in Rats. ALI, B. H.; BEEGAM, S.; AL-LAWATI, I.; WALY, M. I.; ZA'ABI, M. AL; NEMMAR, A. // Physiological Research;2013, Vol. 62 Issue 1, p47 

    Gum acacia (GA) is used in pharmaceutical, cosmetic and food industries as an emulsifier and stabilizer, and in some countries in the traditional treatment of patients with chronic kidney disease (CKD). We have previously found that GA ameliorates adenine -induced chronic renal failure (CRF) in...

  • Effect of Atracylodes Rhizome Polysaccharide in Rats with Adenine-Induced Chronic Renal Failure. YANG, C.; LIU, C.; ZHOU, Q.; XIE, Y. C.; QIU, X. M.; FENG, X. // Indian Journal of Pharmaceutical Sciences;Jan/Feb2015, Vol. 77 Issue 1, p103 

    The aim of the study was to elucidate the therapeutic effects of Atracylodes rhizome polysaccharide on adenine-induced chronic renal failure in rats. Fifty male Sprague Dawley rats were selected and randomly divided in to 5 groups (n=10 rats per group): The normal control group, the chronic...

  • Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Zhu, Wan-Jun; Nakayama, Masaaki; Mori, Takefumi; Nakayama, Keisuke; Katoh, Junichiro; Murata, Yaeko; Sato, Toshinobu; Kabayama, Shigeru; Ito, Sadayoshi // Nephrology Dialysis Transplantation;Jul2011, Vol. 26 Issue 7, p2112 

    Background. Hydrogen (H2) reportedly produces an antioxidative effect by quenching cytotoxic oxygen radicals. We studied the biological effects of water with dissolved H2 on ischemia-induced cardio-renal injury in a rat model of chronic kidney disease (CKD).Methods. Dahl salt-sensitive rats (7...

  • Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats. Ali, Badreldin H.; Adham, Sirin A.; Al Za’abi, Mohammed; Waly, Mostafa I.; Yasin, Javed; Nemmar, Abderrahim; Schupp, Nicole // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    Chrysin (5, 7- dihydroxyflavone) is a flavonoid with several pharmacological properties that include antioxidant, anti-inflammatory and antiapoptotic activities. in this work, we investigated some effects of three graded oral doses of chrysin (10, 50 and 250 mg/kg) on kidney structure and...

  • Anti-aging Effects of Co-enzyme Q10 on Periodontal Tissues. Yoneda, T.; Tomofuji, T.; Ekuni, D.; Azuma, T.; Endo, Y.; Kasuyama, K.; Machida, T.; Morita, M. // Journal of Dental Research;Aug2013, Vol. 92 Issue 8, p735 

    Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention of age-related inflammatory reactions. We examined the effects of topically applied rCoQ10 on...

  • Oxidative Stress, Inflammation, and DNA Damage in Rats after Intratracheal Instillation or Oral Exposure to Ambient Air and Wood Smoke Particulate Matter. Danielsen, Pernille Høgh; Loft, Steffen; Jacobsen, Nicklas Raun; Jensen, Keld Alstrup; Autrup, Herman; Ravanat, Jean-Luc; Wallin, Håkan; Møller, Peter // Toxicological Sciences;Dec2010, Vol. 118 Issue 2, p574 

    Wood combustion is a significant source of ambient particulate matter (PM) in many regions of the world. Exposure occurs through inhalation or ingestion after deposition of wood smoke particulate matter (WSPM) on crops and food. We investigated effects of ambient PM and WSPM by intragastric or...

  • Effect of Mirtazapine on Gastric Oxidative Stress and DNA Injury Created With Methotrexate in Rats. DEMIRYILMAZ, ISMAIL; UZKESER, HULYA; CETIN, NIHAL; HACIMUFTUOGLU, AHMET; BAKAN, EBUBEKIR; ALTUNER, DURDU // Asian Journal of Chemistry;Apr2013, Vol. 25 Issue 4, p2047 

    In this study, effect of mirtazapine on gastric oxidative stress and DNA injury created with methotrexate was investigated. Experimental results showed that GSH (nmol/g protein), MDA (µmol/g protein) and MPO (µ/g protein) in the gastric tissue of the control group rats receiving...

  • Impact of Kidney Transplantation on Biomarkers of Oxidative Stress and Inflammation. Soleymanian, Tayebeh; Ranjbar, Akram; Alipour, Masoumeh; Ganji, Mohammad Reza; Najafi, Iraj // Iranian Journal of Kidney Diseases;Sep2015, Vol. 9 Issue 5, p400 

    Introduction. Hemodialysis patients face oxidative stress and inflammation induced by both kidney dysfunction and hemodialysis procedure. These are supposed to be partly responsible for the excessive cardiovascular morbidity and mortality in hemodialysis patients. We investigated the impact of...

  • Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. Taal, Maarten W.; Brenner, Barry M. // Kidney International;May2000, Vol. 57 Issue 5, p1803 

    Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. In landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (ACEIs) attenuated the decline in renal function associated with chronic...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics