TITLE

Livestock-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) as Causes of Human Infection and Colonization in Germany

AUTHOR(S)
Köck, Robin; Schaumburg, Frieder; Mellmann, Alexander; Köksal, Mahir; Jurke, Annette; Becker, Karsten; Friedrich, Alexander W.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pigs, cattle and poultry are colonized with MRSA and the zoonotic transmission of such MRSA to humans via direct animal contact, environmental contaminations or meat are a matter of concern. Livestock-associated (LA) MRSA are mostly belonging to clonal complex (CC) 398 as defined by multilocus sequence typing. However, MRSA of other clonal lineages including CC5, CC9 and CC97 have also been detected in livestock animals in Germany. Within the framework of a Dutch-German network project (EUREGIO), 14,036 MRSA isolated from clinical and screening specimens (January 2008 - June 2012) derived from human patients in hospitals as well as general or specialized practices in a German region characterized by a high density of livestock production, were subjected to S. aureus protein A (spa) sequence typing. The prevalence of putative LA-MRSA among the human MRSA isolates was determined by analyzing the detection of livestock-indicator (LI) spa types which had already been reported in German livestock. Overall, 578 spa types were detected among the MRSA isolates. LI spa types t011, t034, t108, t1451, t2011, t571, t1456, t1250, t1255, t1580, t2970, t2346, t1344, t2576, t2330 and t2510 (all of which are indicative for LA-MRSA CC398) accounted for 18.6% of all human isolates. The LI spa types t1430 (CC9), t3992 (CC97), t002 (CC5) and t007 (CC30) were found in 0.14%, 0.01%, 1.01% and 0.04% of all human MRSA isolates, respectively. LI spa types associated with CC398 represented 23% of all MRSA from screening samples and a varying proportion among isolates from clinical specimens ranging between 0% in cerebrospinal fluid, 8% in blood cultures and 14% in deep respiratory fluids. Our findings indicate that LA-MRSA are a major cause for human infection and stress the need for close surveillance. Although LA-MRSA CC398 predominates, the occurrence of putative LA-MRSA from other clonal lineages should be monitored.
ACCESSION #
87623579

 

Related Articles

  • Why antibodies disobey the Hippocratic Oath and end up doing harm: a new clue. Pirofski, Liise-anne // Journal of Clinical Investigation;Sep2010, Vol. 120 Issue 9, p3099 

    The appearance of methicillin-resistant Staphylococcus aureus (MRSA) as an endemic microbe, first in hospital and health care settings and more recently in the community, has led to a disastrous situation in which use of the available antibiotic armamentarium is increasingly ineffective and...

  • Sccmec type II gene is common among clinical isolates of methicillin-resistant Staphylococcus aureus in Jakarta, Indonesia. Buntaran, Latre; Hatta, Mochammad; Sultan, Andi R.; Dwiyanti, Ressy; Sabir, Muhammad // BMC Research Notes;2013, Vol. 6 Issue 1, p1 

    Background: Community Acquired Methicillin Resistant Staphylococcus aureus (CA-MRSA) is a strain of MRSA that can cause infections in patients in the community, in which these patients had no previous risk factors for MRSA infection and the patient received 72 hours prior to infection when...

  • Testing for MRSA patients.  // McKnight's Long-Term Care News;Mar2010, Vol. 31 Issue 3, p25 

    The article reports on the six-month project in Maine that would require acute-care hospitals to screen high-risk patients for methicillin-resistant staphylococcus aureus (MRSA).

  • Nurses launch swab screening for MSSA.  // Nursing Standard;8/11/2010, Vol. 24 Issue 49, p7 

    The author reports that the Blackpool, Fylde and Wyre, England Hospitals National Health Service Foundation Trust has introduced a rapid screening swab test for methicillin-sensitive staphylococcus aureus (MSSA).

  • Screening and Decolonization: Does Methicillin-Susceptible Staphylococcus aureus Hold Lessons for Methicillin-Resistant S. aureus? Lucet, Jean-Christophe; Regnier, Bernard // Clinical Infectious Diseases;9/1/2010, Vol. 51 Issue 5, p585 

    Methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) have few structural differences, but their epidemiologies differ profoundly in terms of colonization, infection, and transmission.We compare strategies for controlling hospital infection due to MSSA...

  • Molecular epidemiology of MRSA in 13 ICUs from eight European countries. Hetem, D. J.; Derde, L. P. G.; Empel, J.; Mroczkowska, A.; Orczykowska-Kotyna, M.; Kozińska, A.; Hryniewicz, W.; Goossens, H.; Bonten, M. J. M.; MOSAR WP3 Study Group // Journal of Antimicrobial Chemotherapy (JAC);Jan2016, Vol. 71 Issue 1, p45 

    Objectives: The European epidemiology of MRSA is changing with the emergence of community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA). In this study, we investigated the molecular epidemiology of MRSA during 2 years in 13 ICUs in France, Greece, Italy, Latvia,...

  • MRSA screenings of ICU patients can reduce hospital costs. Clark, Cheryl // HealthLeaders Magazine;Mar2011, Vol. 14 Issue 3, p11 

    The article cites a 2010 University of Minnesota, Minneapolis, study published in the "American Journal of Infection Control" which states that methicillin-resistant Staphylococcus aureus (MRSA) screening of patients admitted to the intensive care unit has proven to be a cost-effective procedure...

  • MRSA distribution and epidemiological procedures evaluation at two hospitals in Northern Poland. Paszko, Krystyna; Michnowska, Ewa; Kurlenda, Julianna; Grinholc, Mariusz; Nakonieczna, Joanna; Bielawski, Krzysztof Piotr // GMS Krankenhaushygiene Interdisziplinaer;2011, Vol. 6 Issue 1, p1 

    In the present study we have analyzed the impact of modified MRSA screening of carriers and patients on epidemiological situation of MRSA during 2008-2010, comparing two regional hospitals with similar bed numbers and similar ward profiles in Northern Poland. In 2008 the proportion of MRSA to...

  • Epidemiology of MRSA in southern Sweden: strong relation to foreign country of origin, health care abroad and foreign travel. Larsson, A.-K.; Gustafsson, E.; Johansson, P.; Odenholt, I.; Petersson, A.; Melander, E. // European Journal of Clinical Microbiology & Infectious Diseases;Jan2014, Vol. 33 Issue 1, p61 

    All notified MRSA cases in Skåne County have been followed since 2000. We have investigated the MRSA epidemiology over time, method of acquisition, whether some spa types are more prone to spread, and/or cause more infections, and the connection between spa type and country of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics