TITLE

Influenza A(H1N1)pdm09-Associated Pneumonia Deaths in Thailand

AUTHOR(S)
Bunthi, Charatdao; Thamthitiwat, Somsak; Baggett, Henry C.; Akarasewi, Pasakorn; Ruangchira-urai, Ruchira; Maloney, Susan A.; Ungchusak, Kumnuan
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The first human infections with influenza A(H1N1)pdm09 virus were confirmed in April 2009. We describe the clinical and epidemiological characteristics of influenza A(H1N1)pdm09-associated pneumonia deaths in Thailand from May 2009-January 2010. Methods: We identified influenza A(H1N1)pdm09-associated pneumonia deaths from a national influenza surveillance system and performed detailed reviews of a subset. Results: Of 198 deaths reported, 49% were male and the median age was 37 years; 146 (73%) were 20–60 years. Among 90 deaths with records available for review, 46% had no identified risk factors for severe influenza. Eighty-eight patients (98%) received antiviral treatment, but only 16 (18%) initiated therapy within 48 hours of symptom onset. Conclusions: Most influenza A(H1N1)pdm09 pneumonia fatalities in Thailand occurred in adults aged 20–60 years. Nearly half lacked high-risk conditions. Antiviral treatment recommendations may be especially important early in a pandemic before vaccine is available. Treatment should be considered as soon as influenza is suspected.
ACCESSION #
87623553

 

Related Articles

  • Oseltamivir (Tamiflu) Resistance in Seasonal Influenza A (H1N1) Viruses. Scully, Mary-Louise // Travel Medicine Advisor;Feb2009, Vol. 19 Issue 2, p5 

    INFLUENZA ACTIVITY HAS BEEN RELATIVELY LOW THUS FAR IN THE 2008-2009 season in the United States. However, of the influenza viruses isolated and tested to date there is significant resistance among the influenza A (H1N1) viruses to the antiviral oseltamivir. As of mid-December 2008, 50 influenza...

  • Influenza vaccines and influenza antiviral drugs in Africa: are they available and do guidelines for their use exist? Duque, Jazmin; McMorrow, Meredith L.; Cohen, Adam L. // BMC Public Health;2014, Vol. 14 Issue 1, p1 

    Background Influenza viruses cause significant morbidity and mortality in Africa, particularly among high-risk groups, but influenza vaccines and antiviral drugs may not be commonly available and used. The main aim of this study was to determine the availability and use of influenza vaccines and...

  • Antiviral drugs for seasonal influenza 2014-2015.  // JAMA: Journal of the American Medical Association;1/27/2015, Vol. 313 Issue 4, p413 

    The article focuses on the antiviral drugs used for the treatment of Influenza disease and considered as an adjunct to influenza vaccination for prophylaxis. Topics discussed include use of Oseltamivir (Tamiflu), and zanamivir (Relenza) for chemoprophylaxis and treatment of influenza, adverse...

  • Facemasks, Hand Hygiene, and Influenza among Young Adults: A Randomized Intervention Trial. Aiello, Allison E.; Perez, Vanessa; Coulborn, Rebecca M.; Davis, Brian M.; Uddin, Monica; Monto, Arnold S. // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Limited vaccine availability and the potential for resistance to antiviral medications have led to calls for establishing the efficacy of non-pharmaceutical measures formitigating pandemic influenza. Our objectivewas to examine if the use of facemasks and hand hygiene reduced rates of...

  • Facemasks, Hand Hygiene, and Influenza among Young Adults: A Randomized Intervention Trial. Aiello, Allison E.; Perez, Vanessa; Coulborn, Rebecca M.; Davis, Brian M.; Uddin, Monica; Monto, Arnold S. // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Limited vaccine availability and the potential for resistance to antiviral medications have led to calls for establishing the efficacy of non-pharmaceutical measures formitigating pandemic influenza. Our objectivewas to examine if the use of facemasks and hand hygiene reduced rates of...

  • Progress treating, preventing influenza. Stephenson, Joan; Stephenson, J // JAMA: Journal of the American Medical Association;11/25/98, Vol. 280 Issue 20, p1729 

    Reports that two experimental drugs which show promise as a treatment for influenza viruses. Details on studies reported at the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy; Clinical trials of the drugs, zanamivir and GS4104; Evidence that neuraminidase inhibitors may...

  • Oseltamivir Pharmacokinetics, Dosing, and Resistance Among Children Aged <2 Years With Influenza. Kimberlin, David W.; Acosta, Edward P.; Prichard, Mark N.; Sánchez, Pablo J.; Ampofo, Krow; Lang, David; Ashouri, Negar; Vanchiere, John A.; Abzug, Mark J.; Abughali, Nazha; Caserta, Mary T.; Englund, Janet A.; Sood, Sunil K.; Spigarelli, Michael G.; Bradley, John S.; Lew, Judy; Michaels, Marian G.; Wan, Wen; Cloud, Gretchen; Jester, Penelope // Journal of Infectious Diseases;Mar2013, Vol. 207 Issue 5, p709 

    Background. Children <2 years of age are at high risk of influenza-related mortality and morbidity. However, the appropriate dose of oseltamivir for children <2 years of age is unknown.Methods. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group...

  • Influenza: Update for the 2013-2014 Season. Campos-Outcalt, Doug // Clinician Reviews;Oct2013, Vol. 23 Issue 10, p28 

    The article focuses on updates for influenza for the 2013-2014 season from the U.S. Centers for Disease Control and Prevention (CDC). It mentions that influenza vaccination is available during the season to those who needed it. It states that the number of available influenza vaccine products...

  • New clues for broad-spectrum flu combat. Harrison, Charlotte // Nature Reviews Drug Discovery;Apr2009, Vol. 8 Issue 4, p276 

    The article presents studies on the strategies to create broad-spectrum influenza treatments. It references the studies by P. Yuan et al published in the February 4, 2009 issue of "Nature," and by D.C. Ekiert et al published in the February 26, 2009 issue of "Science." The development of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics