HIV Drug Resistance and Its Impact on Antiretroviral Therapy in Chinese HIV-Infected Patients

Xing, Hui; Ruan, Yuhua; Li, Jingyun; Shang, Hong; Zhong, Ping; Wang, Xia; Liao, Lingjie; Li, Hanping; Zhang, Min; Xue, Yile; Wang, Zhe; Su, Bin; Liu, Wei; Dong, Yonghui; Ma, Yanling; Li, Huiqin; Qin, Guangming; Chen, Lin; Pan, Xiaohong; Chen, Xi
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Background: Highly active antiretroviral therapy (HAART) has significantly decreased mortality among Chinese HIV patients. However, emerging HIV drug resistance (HIVDR) poses a growing threat to the long-term success and durability of HAART. Methods: Three cross-sectional surveys were conducted across the country from 2004 to 2006, respectively. Patients completed a questionnaire and provided blood for CD4 cell count, HIV viral load (VL), and HIV resistance genotyping. Factors associated with HIVDR were identified by logistic regression. Results: 3667 unique patients were included across the three surveys. Among 2826 treatment-experienced patients, median duration of treatment was 17.4 (IQR 8.6–28.4) months and HIVDR was identified in 543 (19.2%). Factors significantly associated with HIVDR included ART drug distribution location, CD4 cell count, initial HAART regimen, self-reported medication adherence, and province. Conclusions: Virologic failure increased over time on therapy but a significant proportion of patients in failure had no resistance mutations identified, suggesting that treatment adherence is suboptimal and must be emphasized. Due to the significantly higher risk of HIVDR in certain provinces, additional steps to reduce HIVDR should be taken.


Related Articles

  • Relationships Between HIV Disease History and Blood HIV-1 DNA Load in Perinatally Infected Adolescents and Young Adults: The ANRS-EP38-IMMIP Study. Avettand-Fenoel, Véronique; Blanche, Stéphane; Le Chenadec, Jérôme; Scott-Algara, Daniel; Dollfus, Catherine; Viard, Jean-Paul; Bouallag, Naima; Benmebarek, Yassine; Rivière, Yves; Warszawski, Josiane; Rouzioux, Christine; Buseyne, Florence // Journal of Infectious Diseases;May2012, Vol. 205 Issue 10, p1520 

    Background Our aim was to study the impact of lifelong human immunodeficiency virus (HIV) disease history on the current immune and virological status of perinatally infected patients reaching adulthood. We evaluated blood cell–associated HIV DNA load as an indicator of cell-associated...

  • Antiretroviral Treatment Breaks Limit CD4 Count Gains and Raise Death Risk.  // HIV Treatment ALERTS!;Mar2011, p3 

    The article presents a study on the effect of antiretroviral therapy on HIV patients in Switzerland. It shows that there are fewer CD4 cells in patients who interrupted their antiretroviral therapy and they have an increased risk of death and new AIDS diseases. According to the study, the risk...

  • Tetracycline and T-cell Activation. Winslow, Dean L. // Infectious Disease Alert;Jun2010, Vol. 29 Issue 9, p105 

    CD4+ T cells were obtained from HIV-negative donors and HIV-positive patients receiving HAART with suppressed viremia. Using a single-cycle replication system and an X4 pseudovirus used to infect cells, minocycline, at concentrations from 0-50 ug/mL, demonstrated a dose-dependent reduction in...

  • Long-Term CD4 Cell Count Recovery among Thai Naive HIV-Infected Patients Initiating HAART at Low CD4 Cell Count. Romanee Chaiwarith; Parichart Salee; Wilai Kotarathitithum; Thira Sirisanthana; Khuanchai Supparatpinyo // Current HIV Research;May2009, Vol. 7 Issue 3, p340 

    CD4 T cell recovery after highly active antiretroviral therapy (HAART) has been reported mostly from developed countries. A retrospective cohort study was conducted among naïve HIV-infected patients initiating HAART between July 1, 2001 and December 31, 2004 at Chiang Mai University,...

  • HIV-1 Plasma RNA level and CD4 cell count in a large urban HIV-1-infected patient population from 1997 to 2000. Shan, Hua; Piwowar-Manning, Estelle; Thompson, Richard E.; Brooks Jackson, J. // International Journal of STD & AIDS;Nov2003, Vol. 14 Issue 11, p740 

    We evaluated the change in plasma HIV-1 RNA level and CD4 cell counts in an HIV-1-infected population between 1997 and 2000. Both the mean and the median values of plasma HIV-1 RNA level decreased with time with the exception of 1998. The mean and medians for CD4 cell count appear to be fairly...

  • Valganciclovir Reduces T Cell Activation in HIV-infected Individuals With Incomplete CD4+ T Cell Recovery on Antiretroviral Therapy. Hunt, Peter W.; Martin, Jeffrey N.; Sinclair, Elizabeth; Epling, Lorrie; Teague, Juli; Jacobson, Mark A.; Tracy, Russell P.; Corey, Lawrence; Deeks, Steven G. // Journal of Infectious Diseases;May2011, Vol. 203 Issue 10, p1474 

    Background. Elevated immune activation persists during treated human immunodeficiency virus (HIV) infection and is associated with blunted CD4 recovery and premature mortality, but its causes remain incompletely characterized. We hypothesized that asymptomatic cytomegalovirus (CMV) replication...

  • Earlier start for HIV treatment indicated.  // Clinical Advisor;Jun2009, Vol. 12 Issue 6, p15 

    The article reports on the reduction of mortality risks by 94% of HIV patients if physicians in the U.S. start antiretroviral therapy when CD4 antigens counts are as high as 500 cells/uL. It notes that such advice was formulated from data based on older medications that produced more side...

  • Impact of long-term viral suppression in CD4+ recovery of HIV-children on Highly Active Antiretroviral Therapy. Resino, Salvador; Resino, Rosa; Leon, Juan A; Bellon, José M; Martin-Fontelos, Pablo; Ramos, Jose T; Gurbindo-Gutierrez, Dolores; de Jose, Maria I; Ciria, Luis; Muñoz-Fernandez, Maria A // BMC Infectious Diseases;2006, Vol. 6 Issue 1, p10 

    Background: The effects of HAART may differ between children and adults because children have a developing immune system, and the long-term immunological outcome in HIV-infected children on HAART is not well-known. A major aim of our study was to determine CD4+ evolution associated with...

  • Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance. Fogli, Manuela; Torti, Carlo; Malacarne, Fabio; Fiorentini, Simona; Albani, Melania; Izzo, Ilaria; Giagulli, Cinzia; Maggi, Fabrizio; Carosi, Giampiero; Caruso, Arnaldo // Clinical & Developmental Immunology;2012, p1 

    Alterations of B cell subpopulations have been described up to date as characterizing advanced stage of HIV-1 infection. However, whether such defects are relevant in subjects with a preserved number of CD4+ T cells (>350 cells/μL) is unclear. In a crosssectional study, we investigated if...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics