TITLE

Comparative Pharmacokinetics of Enrofloxacin, Danofloxacin, and Marbofloxacin After Intravenous and Oral Administration in Japanese Quail (Coturnix coturnix japonica)

AUTHOR(S)
Haritova, Aneliya; Dimitrova, Dimitrichka; Dinev, Toncho; Moutafchieva, Rumyana; Lashev, Lubomir
PUB. DATE
March 2013
SOURCE
Journal of Avian Medicine & Surgery;Mar2013, Vol. 27 Issue 1, p23
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A population approach was used to evaluate the pharmacokinetic parameters of 3 fluoroquinolones administered to Japanese quail (Coturnix coturnix japónica). Healthy adult quail (n = 50) were divided into 3 groups, each administered a separate intravenous and oral dose of the compounded drug: enrofloxacin at 10 mg/kg (n = 18; 9 male, 9 female), danofloxacin at 10 mg/kg (n = 12; 6 male, 6 female), and marbofloxacin at 5 mg/kg (n = 20; 10 male, 10 female). A fourth group was used as a control (n = 5). Enrofloxacin was metabolized extensively to ciprofloxacin, while no metabolites of either danofloxacin or marbofloxacin were detected. The volume of distribution was high, greater than 1 in all cases, and highest for danofloxacin, followed by enrofloxacin, then marbofloxacin. The total body clearance was higher in quail than that reported for other avian species with the exception of ostriches. As in mammals, the lowest clearance rate of the 3 fluoroquinolones was observed for marbofloxacin. Enrofloxacin was absorbed most rapidly, followed by marbofloxacin, then danofloxacin. The highest bioavailability was observed for danofloxacin followed by marbofloxacin, while very low bioavailability with significant conversion to ciprofloxacin was observed for enrofloxacin. Population analysis showed low intersubject variability for danofloxacin and marbofloxacin in contrast to that for enrofloxacin and its main metabolite, ciprofloxacin. Because of their more favorable pharmacokinetic properties after oral administration, either danofloxacin or marbofloxacin appears to be preferable to enrofloxacin for the treatment of susceptible bacterial infection in Japanese quail.
ACCESSION #
87602624

 

Related Articles

  • Development and Performances of a Japanese Quail Line Homozygous for the Diabetes Insipidus (di) Mutation. Minvielle, F.; Grossmann, R.; Gourichon, D. // Poultry Science;Feb2007, Vol. 86 Issue 2, p249 

    A strain of Japanese quail with the polyuria disorder (excessive urination) was developed from founders that regurgitated water spontaneously. A backcross with a nonpolyuric quail line showed that the polyuric strain was fixed for an autosomal recessive mutation that also induced polydipsia...

  • Comparative cytogenomics of poultry: mapping of single gene and repeat loci in the Japanese quail ( Coturnix japonica). McPherson, Marla; Robinson, Charmaine; Gehlen, Lida; Delany, Mary // Chromosome Research;Apr2014, Vol. 22 Issue 1, p71 

    Well-characterized molecular and cytogenetic maps are yet to be established in Japanese quail ( Coturnix japonica). The aim of the current study was to cytogenetically map and determine linkage of specific genes and gene complexes in Japanese quail through the use of chicken ( Gallus gallus) and...

  • Pharmacokinetic interaction between ketoconazole and SPP301 in healthy volunteers. Dieterle, W.; Mann, J. // International Journal of Clinical Pharmacology & Therapeutics;2006, Vol. 44 Issue 7, p326 

    Background: SPP301 is a potent and highly selective ETA receptor blocker. The primary aim of the present study was to investigate the effect of the potent CYP3A4 inhibitor ketoconazole on the pharmacokinetics of SPP301. Methods: In a randomized, open-label 2-period oral crossover study, 12...

  • Child-Proofing DRUGS. Zielinska, Edyta // Scientist;Mar2012, Vol. 26 Issue 3, p32 

    The article focuses on the administration of drugs in children. It says that researchers have studied the impact of drug pharmacokinetics in the changing physiology of a child from birth to adolescence. It states that the difference in the water content in the body of a child and an adult...

  • Metabolic Profile of Famprofazone Following Multidose Administration. Rodriguez, April T.; Valtier, Sandra; Cody, John T. // Journal of Analytical Toxicology;Sep2004, Vol. 28 Issue 6, p432 

    Evaluates the administration consistent with normal therapeutic use of famprofazone drug. Determination of the metabolic profile of methamphetamine and amphetamine; Challenges in analyzing and interpreting drug-test results for amphetamines; Analysis of the concentrations of the drug.

  • PHARMACOKINETICS OF TOPICAL PRODUCTS. McAuley, W. J.; Kravitz, L. // Dermatological Nursing;Jun2012, Vol. 11 Issue 2, p40 

    Pharmacokinetics is the study of changes in drug concentrations in the body with time. It is commonly considered in four main phases: absorption, distribution, metabolism and excretion. Following topical administration, drugs must first be absorbed into the skin, from where they distribute...

  • The Hows and Whys of Pharmacokinetics. Abelson, Mark B. // Review of Ophthalmology;Oct2015, Vol. 22 Issue 10, p74 

    The article discusses the principles that underlie the concept of pharmacokinetics in ophthalmology. Topics include a brief explanation of the concept, the methods used by clinicians for administering drugs to eye patients which include topical administration and injections, and the advantages...

  • 'Hedged' prescribing for partially compliant patients. Urquhart, John; Vrijens, Bernard // Clinical Pharmacokinetics;2006, Vol. 45 Issue 1, p105 

    The article focuses on the views of the author on several ways which can be used for counterbalancing omitted doses. The authors suggest these ways should be referred to as hedging. In cases of delayed or omitted doses, which is known as partial compliance, substantially higher doses should be...

  • Absence of time-dependent artesunate pharmacokinetics in healthy subjects during 5-day oral administration. Diem Thuy, L.; Ngoc Hung, L.; Danh, P.; Na-Bangchang, K. // European Journal of Clinical Pharmacology;Oct2008, Vol. 64 Issue 10, p993 

    The aim of the present study was to investigate the existence of time-dependent pharmacokinetics of artesunate (ARS) during 5 consecutive days of oral administration to 10 healthy Vietnamese subjects (aged 21–52 years and weighing 49–90 kg). Each volunteer received 200 mg oral...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics