TITLE

Neutrophil Gelatinase-Associated Lipocalin (NGAL) -- a potential biomarker for early diagnosis of acute rejection in renal transplantation

AUTHOR(S)
Moise, A.; Şerbănescu, B.; Gîngu, C.; Constantinescu, I.
PUB. DATE
October 2012
SOURCE
Romanian Journal of Urology;2012, Vol. 11 Issue 4, p26
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Early diagnosis of kidney allograft dysfunction and treatment of subclinical rejection is crucial to the management and long-term survival of the transplanted kidney. in our study, we sought to assess whether NGAL represented a novel, sensitive marker of kidney function in adult patients with kidney transplantations. Material and methods: We have evaluated thirty-eight patients (23 men and 15 women) who underwent kidney transplantation in 2012 in Fundeni Clinical Institute. The study design consist into two groups according to donor source: first group (A) have included patients who had living-related donor and the second group (B) recipients who received kidney harvested from cadaveric donor. Plasma NGAL concentrations was performed from samples collected prior transplantation and then on days 3, 10 and 30 after transplantation, using commercial kits (AntibodyShop, Gentofte, Denmark). Serum creatinine was assessed at the same time, using an automated analyzer Dimension (Siemens, Germany). Results: Pretransplant, NGAL values are significantly higher, closely correlated with serum creatinine. Posttransplantation, higher levels of NGAL were obtained on days 3 and 10, especially in group B. No significant difference between the two groups have been noted one month after transplantation. Also, five recipients had elevated NGAL plasma levels (>350ng/ml) a few days before the acute rejection occurrence. Conclusions: NGAL could be considered a sensitive biomarker of renal function. Routine measurement of serum/urinary NGAL could increase the chances of early diagnosis of acute rejection, even subclinical rejection, allowing promptly institution of therapeutic measures for the protection of renal function, thereby improving prognosis.
ACCESSION #
87600126

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics