Disfuncţia cronică de grefă, accident sau fatalitate?

Bucşa, Cristina Alina; Tacu, Beatrice Dorina; Kerezsy, Eminee; Sinescu, I.
October 2012
Romanian Journal of Urology;2012, Vol. 11 Issue 4, p10
Academic Journal
Kidney transplantation is the optimal therapy for the most of the patients with end stage renal disease. One year graft survival was significantly improved in the previous decades, thanks to the new immunosuppressive drugs that had decreased the incidence of acute rejection. However the late survival statistics remain unimproved. Late graft damage is not a specific entity, because both immunologic and non-immunologic factors, donor and recipient factors contribute to long term graft survival. Early detection and intervention are very important in the management of the risk factors before irreversible lesions will occur. This paper reviews recent studies searching the various causes of late allograft failure and the strategies for its prevention and treatment.


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