TITLE

Are the Serum Biomarkers Pepsinogen I and II Good Predictors for the Detection of Subjects with Atrophic Gastritis in Areas that have Different Gastric Cancer Incidence?

AUTHOR(S)
Mohamadkhani, Ashraf; Darvish Moghaddam, Sodaifam; Salmanroghani, Hassan; Allafsghari, Amin; Yazdanbod, Abbas; Mirzaei, Mahboobeh; Haj-Sheykholeslami, Arghavan; Bashiri, Jafar; Sadjadi, Alireza; Massarrat, Sadegh
PUB. DATE
April 2013
SOURCE
Archives of Iranian Medicine (AIM);Apr2013, Vol. 16 Issue 4, p208
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Northern Iran (Ardabil) is characterized by a high gastric cancer (GC) rate, whereas Southern Iran (Kerman and Yazd) has a low GC rate. The aim of this study is to verify the potential for pepsinogen I and II to detect atrophic gastritis (AG) in both high and low risk populations for GC. Methods: Sera of blood donors and patients with GC from Ardebil, Kerman and Yazd were used to measure levels of pepsinogen I, II and H. pylori IgG antibody. GC rates in these cities were determined according to the Cancer Registry and upper gastrointestinal (GI) endoscopy results. Results: There were 449 subjects with an average age of 45 ± 15 years. The GC rate in the endoscopy units of the hospital in Ardabil was four times higher than Kerman or Yazd. The mean serum pepsinogen I levels did not differ between Ardabil (102 ± 42.6 µg/mL), Kerman (103.3 ± 49.8 µg/mL), and Yazd (111.7 ± 39 µg/mL). Pepsinogen II levels were: 8.1 ± 4.7 µg/mL (Ardabil), 7.5 ± 5.3 µg/mL (Kerman), and 7.6 ± 4.4 µm\L (Yazd), which were not different. The H. pylori infection rates were: Ardabil (61 %), Kerman (55%), and Yazd (73%). A low ratio of pepsinogen I to II (<3) was seen in Ardabil (1.3%), Kerman (1.9%), and Yazd (0.0%), which was not significant. A total of 51.9% of GC patients from Ardabil had normal pepsinogen I (≥70 µg/mL) levels and pepsinogen I/II ratios that were >5. Conclusion: Serum biomarkers pepsinogen I and II and their ratios are probably not sensitive predictors of AG in areas that have either a high or low GC prevalence. This finding is likely related to the lack of an association between GC and advanced AG.
ACCESSION #
87590335

 

Related Articles

  • Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt. Anwar, M. M.; Youssef, A. I.; Sheta, M. I.; Zaki, A.; Bernaba, N. R.; El-Toukhi, M. A. // Eastern Mediterranean Health Journal;May2012, Vol. 18 Issue 5, p501 

    The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer (serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic...

  • Gastric Cancer Mortality in a High Incidence Area: Long-term follow-up of Helicobacter pylori-related Precancerous Lesions in the General Population. Boreiri, Majid; Samadi, Fatemeh; Etemadi, Arash; Babaei, Masoud; Ahmadi, Emad; Sharifi, Amir Houshang; Nikmanesh, Arash; Houshiar, Afshin; Pourfarzi, Farhad; Yazdanbod, Abbas; Alimohammadian, Masoomeh; Sotoudeh, Masoud // Archives of Iranian Medicine (AIM);Jun2013, Vol. 16 Issue 6, p343 

    Background: Due to a lack of clear criteria for recognizing subjects at risk of progression to gastric cancer (GC), this cohort study seeks to identify predictors of GC death in a high-risk population. Methods: During 2000-2001, 1011 randomly selected residents of Ardabil, Iran without a history...

  • Sobrevida de pacientes con cáncer gástrico en el Perú, 2009-2010. Tolentino, Carlos Alvarado // Revista Panamericana de Salud Publica;Mar2015, Vol. 37 Issue 3, p133 

    Objective. Determine the survival rate of patients diagnosed with stomach cancer in 2009-2010 in Peru. Methods. A retrospective cohort study was conducted of patients diagnosed with stomach cancer registered in the National Epidemiological Surveillance System (SNVE) of the Directorate...

  • The association between objective tongue color and endoscopic findings: results from the Kyushu and Okinawa population study (KOPS). Mosaburo Kainuma; Norihiro Furusyo; Yoshihisa Urita; Masaharu Nagata; Takeshi Ihara; Takeshi Oji; Toshiya Nakaguchi; Takao Namiki; Jun Hayashi // BMC Complementary & Alternative Medicine;10/16/2015, p1 

    Background: The relation between tongue color and gastroesophageal disease is unclear. This study was done to investigate the associations between tongue color (TC), endoscopic findings, Helicobacter.pylori infection status, and serological atrophic gastritis (SAG). Methods: The participants...

  • Serum Selenium Level in Patients with Gastric Non-Cardia Cancer and Functional Dyspepsia. Nezhad, Zahra Hosseini; Moghaddam, Sodaif Darvish; Zahedi, Mohammad Javad; Hayatbakhsh, Mehdi; Sharififar, Fariba; Meimand, Farzane Ebrahimi; Nazari, Mahdieh // Iranian Journal of Medical Sciences;May2015, Vol. 40 Issue 3, p214 

    Background: Gastric cancer (GC) is the most common gastrointestinal cancer in Iran. Helicobacter pylori (H. pylori) accounts as one of the main risk factors for gastric non-cardia cancer (GNCC). It is suggested that high serum selenium level may have a protective role in GNCC. In this...

  • Urinary CD80 levels as a diagnostic biomarker of minimal change disease. Ling, Chen; Liu, Xiaorong; Shen, Ying; Chen, Zhi; Fan, Jianfeng; Jiang, Yeping; Meng, Qun // Pediatric Nephrology;Feb2015, Vol. 30 Issue 2, p309 

    Background: Early diagnosis of minimal change disease (MCD) in nephrotic syndrome (NS) patients remains challenging. Doctors often make a diagnosis of MCD using invasive renal biopsy. CD80, a transmembrane protein, is present on podocytes in a number of experimental models of NS. Urinary CD80...

  • The Levels of Asymmetric Dimethylarginine in Patients with Isolated Coronary Artery Ectasia. Erden, İsmail; Çakcak Erden, Emine; Bahadır Sözen, Serhat; Kayapınar, Osman; Onur Çağlar, Sabri; Başar, Cengiz // European Journal of General Medicine;2010, Vol. 7 Issue 4, p404 

    No abstract available.

  • Endocan—A Novel Inflammatory Indicator in Newly Diagnosed Patients With Hypertension: A Pilot Study. Balta, Sevket; Mikhailidis, Dimitri P.; Demirkol, Sait; Ozturk, Cengiz; Kurtoglu, Ertugrul; Demir, Mustafa; Celik, Turgay; Turker, Turker; Iyisoy, Atila // Angiology;Oct2014, Vol. 65 Issue 9, p773 

    Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell–specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we...

  • Study of serum cystatin C as a reliable marker for metabolic syndrome. Amirrasoul, Hooshang; Asefy, Zahra; kazerouni, Faranak; Taghikhani, Mohammad // Iranian Journal of Diabetes & Lipid Disorders;2011, Vol. 10, p1 

    Background: Serum concentration of cystatin C, a marker of glomerular filtration, has been associated with cardiovascular disease (CVD). The aim of this study was to elucidate the association of serum C with metabolic syndrome as a constellation of cardiovascular risk factors. Methods: The study...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics