TITLE

Association of PPARG gene polymorphism (Pro12Ala) with type 2 diabetes in the Iranian population

AUTHOR(S)
Mohammadi-Asl, Javad; Soheil-Nezhad, Aniseh; Saremi, Leila; Rahim, Fakher
PUB. DATE
April 2013
SOURCE
HealthMed;2013, Vol. 7 Issue 4, p1329
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: The present study aimed to investigate the relationship between Pro12Ala polymorphism and T2DM occurrence in Iranian population. Methods: Totally, 80 cases and 80 healthy matched controls were included in the study. PCR-RFLP technique was applied to investigate the polymorphism. Data were analyzed by χ² test using SPSS software. Results: The G allele (Ala 12) may has a modest and protective association with the development of T2DM in Iranian population (OR=2.117; 95% CI: 1.016-4.455; P=0.022) while, Pro allele may consider as a risk factor to make individual prone to T2DM (OR=0.472; 95% CI: 0.224-0.984; P=0.022). There was a 1.9-fold increase in the risk of T2DM associated with the CC allele (adjusted OR: 1.94, 95% CL 0.92-4.01). In contrast, there was no association between the CG polymorphism and the risk of T2DM (adjusted OR: 0.51, 95% CL 0.24-1.03) Conclusions: The PPARG gene polymorphism has a modest association with the development of T2DM in Iranian patients.
ACCESSION #
87508736

 

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