TITLE

Anti diabetic Potential of Euphorbia neriifolia Linn. in Alloxan Induced Diabetic Rats

AUTHOR(S)
Mansuri, Mushir I.; Patel, Vishnu M.
PUB. DATE
May 2012
SOURCE
Journal of Pharmacy Research;2012, Vol. 5 Issue 5, p2571
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Euphorbia neriifolia Linn. (Euphorbiaceae) is traditionally used to treat diabetes mellitus. The extract of Euphorbia neriifolia Linn. are having potential in the development of drug for diabetes due to their antidiabetic activity. Purpose of the study was to evaluate the antidiabetic activity of ethanolic extracts of leaves of Euphorbia neriifolia Linn. (Euphorbiaceae) in alloxan induced diabetic rats. Ethanolic extracts (200 and 400 mg/kg body weight), were administered orally to Wistar albino rats of either sex. Alloxan monohydrate120mg/kg was used to induce diabetes mellitus. Glibenclamide 2.5mg/kg,p.o was used as standard drug. The parameters studied included oral glucose tolerance test, fasting blood glucose and serum lipid profile. In oral glucose tolerance test, reduction of fasting blood glucose levels took place from 60 min of extract administration. The extracts produced a dose-dependent fall in fasting blood glucose (FBG). After 15 days of treatment with extracts the maximum reduction in FBG was observed in diabetic rats treated with ethanolic extract 400 mg/kg dose. Serum lipid levels were reversed towards near normal in treated rats as compared to diabetic control. The results demonstrate that Euphorbia neriifolia Linn.(Euphorbiaceae) possesses significant antidiabetic activity in diabetic rats. The results suggest that Euphorbia neriifolia Linn. has antidiabetic activity.
ACCESSION #
87432698

 

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