Odumosu, Bamidele Tolulope; Adeniyi, Bolanle A.; Hannah, Dada-Adegbola; Chandra, Ram
July 2012
International Journal of Pharmaceutical Sciences Review & Resear;Jul/Aug2012, Vol. 15 Issue 2, p11
Academic Journal
Pseudomonas aeruginosa remains one of the most dreaded resistant pathogens mostly encountered in infections worldwide. However; serious infections due to this bacterium are predominantly hospital-acquired. This present study is aimed at investigating the resistance patterns and susceptibilities of P. aeruginosa isolated from hospitals in Southwest Nigeria. A total of 54 unrelated clinical strains of P. aeruginosa isolated from 5 hospitals in Southwest Nigeria comprises of 38.9% isolated from urine, 20.4% from wounds, and 11.1% from pus while the remaining 29.6% were distributed among other clinical sites. Antimicrobial susceptibility testing for 21 antibiotics and minimum inhibitory concentration (MIC) was done by disk diffusion and E-test method respectively. Each isolate was resistant to = 3 classes of antibiotics, 24 (44.44%) were resistant to 4-9 antibiotics; 17 (31.48%) were resistant to 10 ? 13 antibiotics; 11(20.37%) were resistant to 14 - 16 antibiotics and 2 (3.70%) were resistant to 17 - 19 antibiotics. Thirty (55.55%) isolates were resistant to = 10 antibiotics. High rates of resistance were recorded for ampicillin (100%), tetracycline (100%), amoxicillin/clavulanate acid (100%), ticarcillin/clavulanate acid (87.0%), kanamycin (79.6%), carbenicillin (63.0%) and cefotaxime (46.3%). Highest number of susceptible isolates (98.1%) and (92.6%) were recorded for colistin and imipenem respectively. The highest MIC recorded for cefotaxime, ciprofloxacin, ceftazidime, piperacillin, and amikacin were 30, 240, 240, 240, and 256μg/ml respectively. The resistance profiles observed in this study suggest a prevalence of P. aeruginosa strains harbouring multiple resistance mechanisms in Southwest Nigeria, which could limit available therapeutic options for infections caused by these multidrug resistant strains.


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