TITLE

DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CINITAPRIDE AND PANTOPRAZOLE IN COMBINED DOSAGE FORM

AUTHOR(S)
Mevada, Zalak N.; Kalsariya, Naresh; Chauhan, Renu; Shah, Shailesh; Shah, Dinesh
PUB. DATE
May 2012
SOURCE
International Journal of Pharmaceutical Sciences Review & Resear;May/Jun2012, Vol. 14 Issue 2, p102
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new, rapid, precise, selective and sensitive Q-absorbance ratio method is developed for the simultaneous estimation of cinitapride (CNT) and pantoprazole (PNT) in combined dosage form. In the developed method, absorbance was measured at 279 nm (isoabsorptive point) and 289.6 nm (λmax of Pantoprazole). The drugs obeyed the Beer's law in the concentration range of 1-5 μg/mL and 13-65 μg/mL respectively for cinitapride and pantoprazole. Accuracy of the method was determined by recovery studies and was found to be 101.32 % and 98.9 % for Pantoprazole and Cinitapride respectively. The developed method is simple, precise, rapid and selective. It can be used for routine analysis of both drugs in bulk as well as in pharmaceutical formulations.
ACCESSION #
87366710

Tags: DRUGS -- Dosage forms;  SPECTROPHOTOMETRY;  SIMULTANEOUS equations;  SOLID dosage forms;  PHARMACOLOGY;  BIOTECHNOLOGY

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics