Formulation and Evaluation of Enteric coated Sustained release tablets of Flurbiprofen for Chronotherapeutic treatment of Rheumatoid Arthrities

Hadi, Mohd Abdul; Rao, A. Srinivasa; Dattatray, Khope Hema; Jyothi, B
November 2012
Journal of Pharmacy Research;2012, Vol. 5 Issue 11, p5093
Academic Journal
Enteric coated tablets of Flurbiprofen were developed, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The drug excipient mixtures were subjected to pre-formulation studies. The tablets were prepared by using wet granulation technique using polymers HPMC K15, HPMC K100 as release retarding agents. And 20% solution of Eudragit L 100 with Iso propyl alcohol and Di Ethyl Phthalate used for enteric coat. The tablets were subjected to physicochemical studies, in- vitro drug release and stability studies. FTIR studies shown there was no interaction between drug and polymers. The physicochemical properties of tablets were found within the limits. The drug release from the optimized formulations was extended for a period of 12 hrs i.e. first 2 hrs no drug release was observed and gradually drug release was increased up to 12 hrs by using HPMC K100 with other excipients. The optimized formulations were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern.


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