TITLE

Formulation and Evaluation of Enteric coated Sustained release tablets of Flurbiprofen for Chronotherapeutic treatment of Rheumatoid Arthrities

AUTHOR(S)
Hadi, Mohd Abdul; Rao, A. Srinivasa; Dattatray, Khope Hema; Jyothi, B
PUB. DATE
November 2012
SOURCE
Journal of Pharmacy Research;2012, Vol. 5 Issue 11, p5093
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Enteric coated tablets of Flurbiprofen were developed, so that the variability in gastric emptying time can be overcome and a colon-specific release can be achieved. The drug excipient mixtures were subjected to pre-formulation studies. The tablets were prepared by using wet granulation technique using polymers HPMC K15, HPMC K100 as release retarding agents. And 20% solution of Eudragit L 100 with Iso propyl alcohol and Di Ethyl Phthalate used for enteric coat. The tablets were subjected to physicochemical studies, in- vitro drug release and stability studies. FTIR studies shown there was no interaction between drug and polymers. The physicochemical properties of tablets were found within the limits. The drug release from the optimized formulations was extended for a period of 12 hrs i.e. first 2 hrs no drug release was observed and gradually drug release was increased up to 12 hrs by using HPMC K100 with other excipients. The optimized formulations were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern.
ACCESSION #
87286013

 

Related Articles

  • Diethyl Phthalate Removal from Water by CTMAB-bentonite. Tang Jing; Fan Kai-min; Huang Xiao-mei; Wang Kun; Liu Dan // Advanced Materials Research;2014, Vol. 997, p728 

    For CTMAB-bentonite, bentonite and cetyltrimethyl ammonium bromide (CTMAB) were used as starting materials. The adsorbent was characterized by X-ray diffraction (XRD) and Fourier transform infrared (FTIR). According to the results of XRD and FTIR, it can be concluded that CTMAB has intercalated...

  • Synthesis and Characterization of Poly(hydroxyethyl methacrylate-co-methacrylic acid) Cross Linked Polymeric Network for the Delivery of Analgesic Agent. Rashid, Haroon; Ahmad, Mahmood; Minhas, Muhammad Usman; Sohail, Muhammad; Aamir, Muhammad Fakhruddin // Journal of the Chemical Society of Pakistan;10/31/2015, Vol. 37 Issue 5, p999 

    Objective of the study was to synthesize a chemically cross-linked poly(hydroxyethylmethacrylate-co-methacrylic acid) hydrogel [p(HEMA-co-MAA hydrogel)] for pH-responsive, controlled drug delivery of Flurbiprofen. pH-sensitive hydrogel drug delivery system was synthesized with the help of poly...

  • Examine the Presence of Chemical Constituents in Tecomella undulata and their Interaction with Lipids. Nagpal, Navneet; Arora, Manisha; Chawla, Amit; Rahar, Sandeep; Kapoor, Reni // International Journal of Research in Pharmacy & Science;Oct-Dec2012, Vol. 2 Issue 4, p60 

    During pre-formulation studies common methods like UV-Spectrophotometric methods, FTIR are used for the study of compatibility. In the present investigation drug-lipid compatibility study was conducted for Tecomella undulata with lipid mixture by using equal ratio of drug: lipid. Objective of...

  • The development of aceclofenac multiparticulate colon specific drug delivery using combination of time dependent polymers. Nicholas, Madhu E.; Panaganti, Shanker; Prabakaran, L.; Jayveera, K. N. // Journal of Pharmacy Research;Dec2011, Vol. 4 Issue 12, p4380 

    The purpose of this research was to develop novel colon specific drug delivery multiparticulate systems for aceclofenac using time dependent polymers, ethyl cellulose and hydroxy propyl cellulose. The pellets were evaluated for physicochemical properties, drug content, erosion characteristics...

  • Crystal Modification of Aceclofenac by Spherical Crystallization to Improve Solubility Dissolution Rate and Micromeritic Properties. Thenge, R. R. // Journal of Pharmacy Research;2012, Vol. 5 Issue 2, p974 

    Aceclofenac a non-steroidal anti-inflammatory drug widely used in the treatment of rheumatoid arthritis. The poor water solubility and poor micromeritic properties of aceclofenac lead to low dissolution rate and poor flow during tableting. The aim of present study was to improve dissolution rate...

  • Study of advanced rheumatoid arthritis. da Silva Carvalho, Carolina; Coelho Andrade, Luiz Eduardo; Keusseyan, Silene Peres; Rangel, João Lucas; Ferreira-Strixino, Juliana; Martin, Airton Abrahão; Raniero, Leandro José // Revista Brasileira de Engenharia Biomédica;Mar2014, Vol. 30 Issue 1, p54 

    Introduction: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose...

  • Development and In vitro Evaluation of Flurbiprofen Microcapsules Prepared by Modified Solvent Evaporation Technique. Sohail, Muhammad Farhan; Shah, Pervaiz Akhtar; Tariq, Imran; Saeed-ul-Hassan, Syed; Amin, Umair; Raza, Syed Atif; Saeed, Tariq; Sultana, Misbah; Hassan Jawa, Najam ul // Tropical Journal of Pharmaceutical Research;Jul2014, Vol. 13 Issue 7, p1031 

    Purpose: To develop modified release microcapsules of flurbiprofen for sustained release and reduced gastrointestinal side effects. Method: A co-polymer containing Eudragit RS 100 and hydroxypropyl methylcellulose (HPMC) in different drug/co-polymer ratios was used for microencapsulation of...

  • Hydrogen Bonding Interaction between 1-Propanol and Acrylic Esters in Non-polar Solvents: An FTIR Study. Dharmalingam, Kurunthu; Ramachandran, Krishnamurthy; Sivagurunathan, Periyasamy // South African Journal of Chemistry;2006, Vol. 59, p75 

    The association between 1-propanol and acrylic esters (methyl methacrylate, ethyl methacrylate and butyl methacrylate) in non-polar solvents, viz. n-heptane, CCl4, and benzene has been investigated by means of FTIR spectroscopy. The formation constants of the 1:1 complexes have been calculated...

  • The Effects of Al2O3 Addition and WO3 Modification on Catalytic Activities of NiO/TiO2 for Acid Catalysis. Jong Rack Sohn; Sung Gyu Lee // Catalysis Letters;Jan2008, Vol. 120 Issue 1/2, p116 

    NiO/Al2O3–TiO2/WO3 catalysts for acid catalysis were prepared by the addition of Al2O3 and the modification with WO3. The strong acid sites were formed through the bonding between dispersed WO3 and TiO2. The larger the dispersed WO3 amount, the higher both the acidity and catalytic...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics