Increases in Proinflammatory Cytokine Levels at Early Ages as a Risk Factor for the Development of Nervous and Mental Pathology

Zubareva, O.; Klimenko, V.
May 2013
Neuroscience & Behavioral Physiology;May2013, Vol. 43 Issue 4, p535
Academic Journal
Proinflammatory cytokines interleukin 1, interleukin 6 (IL-1, IL-6), and tumor necrosis factor α (TNF-α), key mediators in intersystem neuroimmune interactions, represent the common components in different types of prenatal pathology leading to severe neurological and mental disorders. This review describes the characteristics of the expression of proinflammatory cytokines and their receptors in the brain at early ages in normal and pathological conditions, along with their effects on the processes of cell maturation in the CNS; experimental and clinical data from studies of impairments to mental function arising in adults due to increases in IL-1, IL-6, and TNF-α levels in early ontogeny are presented. The roles of these cytokines in the pathogenesis of schizophrenia, attention deficit hyperactivity disorder, autism, and parkinsonism are discussed.


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