Relations between clusters of oxidatively damaged nucleotides and active or open nucleosomes in the rat Nth 1 gene

Nomoto, Minoru; Yamaguchi, Raizo; Kohno, Kimitoshi; Kasai, Hiroshi
March 2002
Oncogene;3/7/2002, Vol. 21 Issue 11, p1649
Academic Journal
Presents a study that examined the molecular mechanism of the restricted formation of damaged nucleotides. Background on the kinds of DNA damage induced by reactive oxygen species; Importance of litigation-mediated polymerase chain reaction in the detection of damaged nucleotides; Impact of ferric nitrilotriacetate, a renal carcinogen, on rats; Analysis of chromatin structures; Results and implications.


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