TITLE

Aripiprazole monotherapy in an adolescent worsens psychosis

AUTHOR(S)
Panigrahi, Mahima; Padhy, Susanta Kumar; Rathi, Rajesh
PUB. DATE
March 2013
SOURCE
Indian Journal of Pharmacology;Mar/Apr2013, Vol. 45 Issue 2, p195
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Early detection and treatment of early onset schizophrenia (EOS) can lead to better outcome. Aripiprazole, a partial agonist of dopamine and a second generation antipsychotic, has been approved specifically for treatment of children with schizophrenia of aged 13-17 years. Though the use of this drug in adults may be associated with worsening of psychosis in occasional cases, no such data is available in adolescents. We report a case of EOS, who had worsening of psychosis with aripiprazole monotherapy. We discuss the possible mechanisms and clinical implications relevant in adolescents, and alert the clinicians to be vigilant in monitoring the patients on aripiprazole, especially after an increase in the dose of this medication.
ACCESSION #
86738731

 

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