Oncogenic humans papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation

Thomas, Miranda; Laura, Richard; Hepner, Karin; Guccione, Ernesto; Sawyers, Charles; Lasky, Laurence; Banks, Lawrence
August 2002
Oncogene;8/1/2002, Vol. 21 Issue 33, p5088
Academic Journal
Presents a study that defined two membrane-associated guanylate kinase homologues (MAGUK) proteins, MAGI-2 and MAGI-3, as cellular targets of mucosal oncogenic human papilloma virus (HPV) E6 proteins. Discussion on the formation of multimolecular complexes; Analysis of homology within the MAGI protein sequences; Implications of the results.


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