TITLE

Reduced Beta-Catenin Expression in the Hippocampal CA1 Region Following Transient Cerebral Ischemia in the Gerbil

AUTHOR(S)
Cho, Jeong-Hwi; Yan, Bing; Lee, Young; Park, Joon; Ahn, Ji; Kim, In; Lee, Jae-Chul; Kim, Young-Myeong; Lee, Bonghee; Cho, Jun; Won, Moo-Ho
PUB. DATE
May 2013
SOURCE
Neurochemical Research;May2013, Vol. 38 Issue 5, p1045
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Beta-catenin, a transcription factor, plays a critical role in cell survival and degradation after stroke. In this study, we examined changes of expression in beta-catenin in the hippocampal CA1 region of the gerbil following 5 min of transient cerebral ischemia. We observed neuronal damage using cresyl violet staining, neuronal nuclei immunohistochemistry and Fluro-Jade B immunofluorescence. Four days after ischemia-reperfusion (I-R), most of pyramidal cells in the CA1 region were damaged. In addition, early damage in dendrites was detected 1 day after I-R by immunohistochemical staining for microtubule-associated protein 2 (MAP-2), and MAP-2 immunoreactivity was hardly detected in the CA1 region 4 days after I-R. We found that beta-catenin (a synapse-enriched cell adhesion molecule) was well expressed in dendrites before I-R. Its immunoreactivity was well colocalized with MAP-2. Chronological change of beta-catenin immunoreactivity was novelty in the present study. Twelve hours after I-R, its immunoreactivity was decreased in the stratum radiatum of the CA1 region, however, its immunoreactivity was increased 1 and 2 days after I-R, and decreased sharply 4 days after I-R. However, we did not find any change in beta-catenin immunoreactivity in the CA2 and CA3 region. In brief, we suggest that early change of beta-catenin expression in the stratum pyramidale of ischemic hippocampal CA1 region is associated with early dendrite damage following transient cerebral ischemia.
ACCESSION #
86449460

 

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