Generation of sub-femtoliter droplet by T-junction splitting on microfluidic chips

Yang, Yu-Jun; Feng, Xuan; Xu, Na; Pang, Dai-Wen; Zhang, Zhi-Ling
March 2013
Applied Physics Letters;3/25/2013, Vol. 102 Issue 12, p123502
Academic Journal
In the paper, sub-femtoliter droplets were easily produced by droplet splitting at a simple T-junction with orifice, which did not need expensive equipments, complex photolithography skill, or high energy input. The volume of the daughter droplet was not limited by channel size but controlled by channel geometry and fluidic characteristic. Moreover, single bead sampling and bead quantification in different orders of magnitude of droplet volumes were investigated. The droplets split at our T-junction chip had small volume and monodispersed size and could be produced efficiently, orderly, and controllably.


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