TITLE

The influence of -330 IL-2 gene polymorphism on relapsing remitting and secondary progressive multiple sclerosis in Iranian patients

AUTHOR(S)
Sayad, Aida; Allameh, Abdolamir; Sayad, Arezou; Noruzinia, Mehrdad; Sarzaeem, Ali
PUB. DATE
March 2013
SOURCE
Neurology Asia;Mar2013, Vol. 18 Issue 1, p83
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Interleukin-2 (IL-2) is identified as the crucial and main immunoregulatory cytokines. Previously, we showed significant association between -330 T/T IL-2 genotype and relapsing remitting MS among Iranian population. In this study we investigated 100 relapsing remitting, 30 secondary progressive MS and 125 healthy controls to compare the relapsing remitting and secondary progressive course MS in association to -330 IL-2 polymorphism. Our results showed that the -330 T/T IL-2 genotype was significantly more frequent in relapsing remitting and secondary progressive MS than controls. The significant increased frequency of -330 T/T IL-2 genotype in secondary progressive than relapsing remitting MS, imply -330 T/T IL-2 genotype can cause higher susceptibility to secondary progressive MS than relapsing remitting.
ACCESSION #
86442147

 

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