MRI features and anti-AQP4 antibody status in Idiopathic inflammatory demyelinating CNS disease (IIDCD) in Thai patients

Prayoonwiwat, Naraporn; Chawalparit, Orasa; Pienpuck, Waraporn; Ngamsombat, Chanon; Wongsripuemtet, Jitsupa; Siritho, Sasitorn
March 2013
Neurology Asia;Mar2013, Vol. 18 Issue 1, p73
Academic Journal
Objective: To evaluate the MRI findings in different status of anti-aquaporin 4 (AQP4) antibody in Thai patients with idiopathic inflammatory demyelinating CNS diseases (IIDCDs). Methods: A retrospective study of 135 IIDCDs patients was performed. The available brain and spinal MRI were reviewed. All were tested for anti-AQP4 antibody. The MRI findings were analyzed for any difference between patients with seronegative and seropositive anti-AQP4 antibody. Results: Eighty cases included 47 seronegative and 33 seropositive anti-AQP4 antibody were reviewed. Forty seven brain and 20 spinal MRIs from the seronegative group and 32 brain MRIs and 27 spinal MRIs (one with only spinal MRI) from the seropositive group were analyzed. There was no significant difference between the two groups upon the number of patients who fulfilled Barkhof's MRI Criteria. When the patients were classified according to the location and pattern of abnormal MRI findings, more cases in the seropositive group had lesions at corticospinal tract or subependymal third/fourth ventricles (p<0.05). Long-extensive spinal cord lesion and central gray matter location were found more in the seropositive group whereas the short segment, peripheral location were found more in the seronegative group (p<0.05). Most of the seropositive cases had lesions at the cervicothoracic level in contrast to the seronegative cases which had more lesions at the thoracic cord level. Conclusion: MRI features were different between IIDCDs patients with seronegative and seropositive anti-AQP4 antibody. The characteristics and locations of the MRI lesions were more appropriate in differentiating between the two conditions rather than the number of the lesions.


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