TITLE

PERK-ing up autophagy during MYC-induced tumorigenesis

AUTHOR(S)
Dey, Souvik; Tameire, Feven; Koumenis, Constantinos
PUB. DATE
April 2013
SOURCE
Autophagy;Apr2013, Vol. 9 Issue 4, p612
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
86440364

 

Related Articles

  • Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster. Nagy, Péter; Varga, Ágnes; Pircs, Karolina; Hegedűs, Krisztina; Juhász, Gábor // PLoS Genetics;Aug2013, Vol. 9 Issue 8, p1 

    Autophagy, a lysosomal self-degradation and recycling pathway, plays dual roles in tumorigenesis. Autophagy deficiency predisposes to cancer, at least in part, through accumulation of the selective autophagy cargo p62, leading to activation of antioxidant responses and tumor formation. While...

  • ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. Hart, Lori S.; Cunningham, John T.; Datta, Tatini; Dey, Souvik; Tameire, Feven; Lehman, Stacey L.; Bo Qiu; Haiyan Zhang; Cerniglia, George; Meixia Bi; Yan Li; Yan Gao; Huayi Liu; Changhong Li; Maity, Amit; Thomas-Tikhonenko, Andrei; Perl, Alexander E.; Albert Koong; Fuchs, Serge Y.; Diehl, J. Alan // Journal of Clinical Investigation;Dec2012, Vol. 122 Issue 12, p4621 

    The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc-induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorigenesis. The accumulation of unfolded proteins in...

  • Antimalarial therapy prevents Myc-induced lymphoma. Dang, Chi V. // Journal of Clinical Investigation;Jan2008, Vol. 118 Issue 1, p15 

    The two modes of self-destruction at the cellular level—apoptosis (self-killing) and autophagy (self-eating)—are thought to be tumor suppressive. In particular, germline loss of function of genes involved in autophagy has been associated with tumorigenesis. However, recent studies,...

  • The Importance of Autophagy Regulation in Breast Cancer Development and Treatment. Zarzynska, Joanna Magdalena // BioMed Research International;2014, Vol. 2014, p1 

    Breast cancer (BC) is a potentially life-threatening malignant tumor that still causes high mortality among women. One of the mechanisms through which cancer development could be controlled is autophagy. This process exerts different effects during the stages of cancer initiation and progression...

  • The Role of Autophagy in Hepatocellular Carcinoma. Yoo Jin Lee; Byoung Kuk Jang // International Journal of Molecular Sciences;Nov2015, Vol. 16 Issue 11, p26629 

    Autophagy is a catabolic process involved in cellular homeostasis under basal and stressed conditions. Autophagy is crucial for normal liver physiology and the pathogenesis of liver diseases. During the last decade, the function of autophagy in hepatocellular carcinoma (HCC) has been evaluated...

  • The Selectivity and Specificity of Autophagy in Drosophila. Nezis, Ioannis P. // Cells (2073-4409);Sep2012, Vol. 1 Issue 3, p248 

    Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite...

  • 3 OF THE BEST Concealer heroes!  // Mail on Sunday;9/ 1/2013, p19 

    BENEFIT PERK UP ARTIST

  • HOT LIST. CLAIRE HYLAND // Mail on Sunday;11/20/2016, p11 

    Getting all perked up

  • Macroautophagy as a Target of Cancer Therapy. Lorin, S�verine; Codogno, Patrice; Djavaheri-Mergny, Mojgan // Current Cancer Therapy Reviews;2007, Vol. 3 Issue 3, p199 

    Macroautophagy (hereafter referred as to autophagy) is a vacuolar lysosomal degradative pathway for cytoplasmic macromolecules and organelles. There is growing evidence that autophagy is controlled by tumor-regulating molecules, and that it is downregulated during the early stages of...

  • Role of autophagy in cancer. Mathew, Robin; Karantza-Wadsworth, Vassiliki; White, Eileen // Nature Reviews Cancer;Dec2007, Vol. 7 Issue 12, p961 

    Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative energy source during periods of metabolic stress to maintain homeostasis and viability. In tumour cells...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics