Involvement of autophagy in the response of tumor cells to PtdIns3K inhibitors

Arcaro, Alexandre
April 2013
Autophagy;Apr2013, Vol. 9 Issue 4, p607
Academic Journal
No abstract available.


Related Articles

  • Autophagic and Apoptotic Effects of HDAC Inhibitors on Cancer Cells. Rikiishi, Hidemi // Journal of Biomedicine & Biotechnology;2011, p1 

    Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and the promotion of tumorigenesis in cancers, novel compounds endowed with histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. Indeed, the potential of HDAC...

  • Autofagia - mechanizm molekularny, apoptoza i nowotwory. Polewska, Joanna // Advances in Hygiene & Experimental Medicine / Postepy Higieny i ;2012, Vol. 66, p921 

    Autophagy is a catabolic process involving the degradation of long-lived proteins and organelles through the lysosomal machinery. In eukaryotic cells, among the three types of autophagy the most extensively studied is macroautophagy. Macroautophagy (hereafter referred to as autophagy) is...

  • Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy. Thomas, Scott; Thurn, Kenneth; Bi�aku, Elona; Marchion, Douglas; M�nster, Pamela // Breast Cancer Research & Treatment;Nov2011, Vol. 130 Issue 2, p437 

    Modulation of estrogen signaling is one of the most successful modalities for the treatment of estrogen receptor (ER)-positive breast cancer, yet de novo and acquired resistance are frequent. Recent data suggests that the induction of autophagy may play a considerable role in promoting tumor...

  • Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway. Lee, C-H; Lin, S-T; Liu, J-J; Chang, W-W; Hsieh, J-L; Wang, W-K // Gene Therapy;Mar2014, Vol. 21 Issue 3, p309 

    Salmonella have been demonstrated to inhibit tumor growth. However, the mechanism of Salmonella-induced tumor cell death is less defined. Autophagy is a cellular process that mediates the degradation of long-lived proteins and unwanted organelles in the cytosol. Tumor cells frequently display...

  • Autophagic cell death: A new frontier in cancer research. Zappavigna, S.; Luce, A.; Vitale, G.; Merola, N.; Facchini, S.; Caraglia, M. // Advances in Bioscience & Biotechnology;Feb2013, Vol. 4 Issue 2, p250 

    Autophagy is a conserved and tightly regulated cellular catabolic process that involves the lysosomal degradation pathway. Intracellular recycling of macromolecules and organelles provided by autophagy is an integral part of normal cellular function and permits cells survival under starvation...

  • EGFR inhibitors and autophagy in cancer treatment. Cui, Jie; Hu, Yun-Feng; Feng, Xie-Min; Tian, Tao; Guo, Ya-Huan; Ma, Jun-Wei; Nan, Ke-Jun; Zhang, Hong-Yi // Tumor Biology;Dec2014, Vol. 35 Issue 12, p11701 

    Epidermal growth factor receptor (EGFR) inhibitor treatment is a strategy for cancer therapy. However, innate and acquired resistance is a major obstacle of the efficacy. Autophagy is a self-digesting process in cells, which is considered to be associated with anti-cancer drug resistance. The...

  • Autophagy in cancer stem/progenitor cells. Lin, Yi-Hui; Huang, Yu-Chun; Chen, Li-Hsin; Chu, Pei-Ming // Cancer Chemotherapy & Pharmacology;May2015, Vol. 75 Issue 5, p879 

    Macroautophagy is widely accepted as a cytoprotective mechanism against various environmental stresses. While inhibition of autophagy is generally considered to increase the susceptibility of cancer cells to therapeutic agents, whether it also plays a similar role in tumor stem cells is unclear...

  • Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells. LELE SONG; HAO LIU; LINYAN MA; XUDNG ZHANG; ZHIWEN JIANG; CHENCHEN JIANG // Oncology Letters;2013, Vol. 6 Issue 4, p1031 

    Radiotherapy and adjuvant cisplatin chemotherapy are the mainstream treatments for nasopharyngeal carcinoma (NPC), which effectively improve the outcome and reduce tumor recurrence. However, the resistance mechanism(s) involved in radiotherapy and chemotherapy, which is the main barrier in NPC...

  • Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster. Nagy, Péter; Varga, Ágnes; Pircs, Karolina; Hegedűs, Krisztina; Juhász, Gábor // PLoS Genetics;Aug2013, Vol. 9 Issue 8, p1 

    Autophagy, a lysosomal self-degradation and recycling pathway, plays dual roles in tumorigenesis. Autophagy deficiency predisposes to cancer, at least in part, through accumulation of the selective autophagy cargo p62, leading to activation of antioxidant responses and tumor formation. While...

  • 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells. Cui Zhang; Yingnan Jiang; Jin Zhang; Jian Huang; Jinhui Wang // International Journal of Molecular Sciences;Jul2015, Vol. 16 Issue 7, p14979 

    8-p-Hdroxybenzoyl tovarol (TAW) is a germacrane-type sesquiterpenoid that can be isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. In this study, the growth inhibitory effects induced by TAW were screened on some types of tumor cells, and the mechanism was investigated on TAW-induced...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics