Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

McAlpine, Fiona; Williamson, Leon E.; Tooze, Sharon A.; Chan, Edmond Y. W.
March 2013
Autophagy;Mar2013, Vol. 9 Issue 3, p361
Academic Journal
No abstract available.


Related Articles

  • Lysosome positioning coordinates mTORC1 activity and autophagy. Poüs, Christian; Codogno, Patrice // Nature Cell Biology;Apr2011, Vol. 13 Issue 4, p342 

    Under nutrient-rich conditions, the nutrient-sensitive kinase mTOR (mammalian target of rapamycin) is recruited to the surface of lysosomes where it becomes activated and can promote cell growth and inhibit autophagy. In contrast, mTOR is inhibited in nutrient-poor conditions, leading to the...

  • Autophagy regulation by nutrient signaling. Russell, Ryan C; Yuan, Hai-Xin; Guan, Kun-Liang // Cell Research;Jan2014, Vol. 24 Issue 1, p42 

    The ability of cells to respond to changes in nutrient availability is essential for the maintenance of metabolic homeostasis and viability. One of the key cellular responses to nutrient withdrawal is the upregulation of autophagy. Recently, there has been a rapid expansion in our knowledge of...

  • The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase. Onyenwoke, Rob U.; Sexton, Jonathan Z.; Feng Yan; Huertas Díaz, María Cristina; Forsberg, Lawrence J.; Major, Michael B.; Brenman, Jay E. // Biochemical Journal;9/15/2015, Vol. 470 Issue 3, p331 

    Autophagy is a complex pathway regulated by numerous signalling events that recycles macromolecules and may be perturbed in lysosomal storage disorders (LSDs). During autophagy, aberrant regulation of the lysosomal Ca2+ efflux channel TRPML1 [transient receptor potential mucolipin 1 (MCOLN1)],...

  • ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif. Shin, Sung Hwa; Lee, Eun Jeoung; Chun, Jaesun; Hyun, Sunghee; Kang, Sang Sun // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Uncoordinated 51-like kinase 2 (ULK2), a member of the serine/threonine kinase family, plays an essential role in the regulation of autophagy in mammalian cells. Given the role of autophagy in normal cellular homeostasis and in multiple diseases, improved mechanistic insight into this process...

  • Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes. Sciarretta, Sebastiano; Yee, Derek; Ammann, Paul; Nagarajan, Narayani; Volpe, Massimo; Frati, Giacomo; Sadoshima, Junichi // Clinical Science;Apr2015, Vol. 128 Issue 7, p387 

    In the past several years, it has been demonstrated that the reactive oxygen species (ROS) may act as intracellular signalling molecules to activate or inhibit specific signalling pathways and regulate physiological cellular functions. It is now well-established that ROS regulate autophagy, an...

  • Bioinformatic mining of kinase inhibitors that regulate autophagy through kinase signaling pathways. YANG YANG; BIAO MA; YE JIN; WEI BEN; DANDAN ZHANG; KEPING JIANG; SHUJUN FENG; LU HUANG; JIANHUA ZHENG // Molecular Medicine Reports;2014, Vol. 10 Issue 6, p3348 

    The aim of this study was to predict the kinase inhibitors that may regulate autophagy. A total of 62 kinases were obtained through text mining by importing the keyword 'autophagy' and a 'protein kinase' Excel file to PubMed. Subsequently, 146 kinases were derivated through screening in the...

  • Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase. Pozuelo-Rubio, M. // Cell Death & Differentiation;Mar2011, Vol. 18 Issue 3, p479 

    14-3-3s are binding proteins with survival functions in cells by interaction with proteins involved in the regulation of cell fate. The role of 14-3-3 during autophagy was investigated, thus, a forced expression of 14-3-3ζ reduces C2-ceramide-induced autophagy, whereas depletion of 14-3-3ζ...

  • Regulation of Autophagy by Kinases. Sridharan, Savitha; Jain, Kirti; Basu, Alakananda // Cancers;2011, Vol. 3 Issue 2, p2630 

    Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with...

  • Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Strohecker, A M; Joshi, S; Possemato, R; Abraham, R T; Sabatini, D M; White, E // Oncogene;11/5/2015, Vol. 34 Issue 45, p5662 

    Deregulation of autophagy has been linked to multiple degenerative diseases and cancer, thus the identification of novel autophagy regulators for potential therapeutic intervention is important. To meet this need, we developed a high content image-based short hairpin RNA screen monitoring levels...

  • The Association of AMPK with ULK1 Regulates Autophagy. Jong Woo Lee; Sungman Park; Takahashi, Yoshinori; Hong-Gang Wang // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Autophagy is a highly orchestrated intracellular bulk degradation process that is activated by various environmental stresses. The serine/threonine kinase ULK1, like its yeast homologue Atg1, is a key initiator of autophagy that is negatively regulated by the mTOR kinase. However, the molecular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics