Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia

Nakashima, Akitoshi; Yamanaka-Tatematsu, Mikiko; Fujita, Naonobu; Koizumi, Keiichi; Shima, Tomoko; Yoshida, Toshiko; Nikaido, Toshio; Okamoto, Aikou; Yoshimori, Tamotsu; Saito, Shigeru
March 2013
Autophagy;Mar2013, Vol. 9 Issue 3, p303
Academic Journal
No abstract available.


Related Articles

  • Maternal serum endoglin as an early marker of pre-eclampsia in high-risk patients. Elhawary, Tarek M.; El-Bendary, Aml S.; Demerdash, Hala // International Journal of Women's Health;2012 Part 2, Vol. 4, p521 

    Background: Pre-eclampsia is a potentially serious condition that still accounts for significant morbidity and mortality for the affected mother and neonate. Although the pathogenesis is not fully understood, it is now widely accepted that vascular endothelial dysfunction is the most important...

  • Before and After Preeclampsia: What Biomarkers are there? Donato, Valentina; Lacquaniti, Antonio; Cernaro, Valeria; Buemi, Antoine; Lupica, Rosaria; Lucisano, Silvia; Buemi, Michele // Current Women's Health Reviews;Nov2012, Vol. 8 Issue 4, p269 

    Preeclampsia is now recognized as a risk factor for developing cardiovascular and renal disease in the mother later in life. Recently, certain substances have been identified, that are be either over- or under-expressed in patients with preeclampsia. One of these biomarkers that is...

  • Membrane and Soluble Forms of Endoglin in Preeclampsia. Oujo, B.; Perez-Barriocanal, F.; Bernabeu, C.; Lopez-Novoa, J. M. // Current Molecular Medicine;Jun2013, Vol. 13 Issue 5, p1345 

    Preeclampsia is a disease of high incidence in pregnant women which complicates pregnancy and may lead to the death of mother and baby. Preeclampsia is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction. Although the causes...

  • MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin. Kaitu'u-Lino, Tu'uhevaha J.; Palmer, Kirsten; Tuohey, Laura; Louie Ye; Stephen Tong // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1 

    Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-organ damage. Soluble endoglin is an anti-angiogenic protein released from placenta and thought to play a central role in causing the endothelial dysfunction and...

  • Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia. Levine, Richard J.; Lam, Chun; Qian, Cong; Yu, Kai F.; Maynard, Sharon E.; Sachs, Benjamin P.; Sibai, Baha M.; Epstein, Franklin H.; Romero, Roberto; Thadhani, Ravi; Karumanchi, S. Ananth // New England Journal of Medicine;9/7/2006, Vol. 355 Issue 10, p992 

    Background: Alterations in circulating soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein, and placental growth factor (PlGF), a proangiogenic protein, appear to be involved in the pathogenesis of preeclampsia. Since soluble endoglin, another antiangiogenic protein, acts...

  • Hypoxic treatment of human dual placental perfusion induces a preeclampsia-like inflammatory response. Jain, Arjun; Schneider, Henning; Aliyev, Eldar; Soydemir, Fatimah; Baumann, Marc; Surbek, Daniel; Hediger, Matthias; Brownbill, Paul; Albrecht, Christiane // Laboratory Investigation (00236837);Aug2014, Vol. 94 Issue 8, p873 

    Preeclampsia is a human pregnancy-specific disorder characterized by a placental pro-inflammatory response in combination with an imbalance of angiogenic factors and clinical symptoms, including hypertension and proteinuria. Insufficient uteroplacental oxygenation in preeclampsia due to impaired...

  • Angiogenesis factors and preeclampsia. Dechend, Ralf; Luft, Friedrich C. // Nature Medicine;Nov2008, Vol. 14 Issue 11, p1187 

    The article comments on a study by R. J. Levine and colleagues which demonstrates an important role for placental-derived soluble antiangiogenic factors as mediators of the pathologies associated with preeclampsia. According to the authors, the findings have implications for the diagnosis,...

  • Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia. Perez-Sepulveda, Alejandra; Monteiro, Lara J.; Dobierzewska, Aneta; España-Perrot, Pedro P.; Venegas-Araneda, Pía; Guzmán-Rojas, Alejandra M.; González, María I.; Palominos-Rivera, Macarena; Irarrazabal, Carlos E.; Figueroa-Diesel, Horacio; Varas-Godoy, Manuel; Illanes, Sebastián E. // PLoS ONE;10/7/2015, Vol. 10 Issue 10, p1 

    Introduction: Preeclampsia is a maternal hypertensive disorder with uncertain etiology and a leading cause of maternal and fetal mortality worldwide, causing nearly 40% of premature births delivered before 35 weeks of gestation. The first stage of preeclampsia is characterized by reduction of...

  • Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Kanasaki, Keizo; Palmsten, Kristin; Sugimoto, Hikaru; Ahmad, Shakil; Hamano, Yuki; Xie, Liang; Parry, Samuel; Augustin, Hellmut G.; Gattone, Vincent H.; Folkman, Judah; Strauss, Jerome F.; Kalluri, Raghu // Nature;6/19/2008, Vol. 453 Issue 7198, p1117 

    Despite intense investigation, mechanisms that facilitate the emergence of the pre-eclampsia phenotype in women are still unknown. Placental hypoxia, hypertension, proteinuria and oedema are the principal clinical features of this disease. It is speculated that hypoxia-driven disruption of the...

  • Response to Plasmapheresis Measured by Angiogenic Factors in a Woman with Antiphospholipid Syndrome in Pregnancy. Mayer-Pickel, Karoline; Horn, Sabine; Lang, Uwe; Cervar-Zivkovic, Mila // Case Reports in Obstetrics & Gynecology;8/27/2015, Vol. 2015, p1 

    An imbalance of angiogenic and antiangiogenic placental factors such as endoglin and soluble fms-like tyrosine kinase 1 has been implicated in the pathophysiology of preeclampsia. Extraction of these substances by plasmapheresis might be a therapeutical approach in cases of severe early-onset...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics