Neuroblastoma anaplásico del bulbo olfatorio con áreas de diferenciación rabdomioblástica. Descripción de un caso

Márquez-Pérez, Trinidad; Pérez-López, Carlos; García-Cabezas, Miguel A.; Castillo, José L.; Gutiérrez-Molina, Manuel
January 2013
Revista Española de Patología;ene-mar2013, Vol. 46 Issue 1, p55
Academic Journal
Olfactory neuroblastoma is a small-cell tumour of neuroectodermal origin occurring in the upper nasal cavity in the region of the cribriform plate, which can show aggressive behaviour and affect intracranial structures. We report a case of a 25 year old male with a mass at the level of nasal cavity that invaded the orbit and the intracranial extracerebral compartment. The mass was removed using a combined neurosurgical and maxillofacial approach and a neuroblastoma was diagnosed. One month later, the patient had an aggressive, mostly intracerebral, recurrence. He underwent further surgery and the neuroblastoma was found to contain areas of rabdomyoblastic differentiation. Although rabdomyoblastic areas within neuroblastoma are extremely rare, when they are present the degree of aggressivity and possibility of recurrence are greatly increased. Thus, surgery should be as radical as possible, even though it does not guarantee long term survival.


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