Concurrent thymic squamous cell carcinoma and disseminated intravascular large B-cell lymphoma. A previously unreported association

Val-Bernal, J. Femando; Mayorga, Marta; Bermúdez, G. Mariuxi
January 2013
Revista Española de Patología;ene-mar2013, Vol. 46 Issue 1, p45
Academic Journal
The incidence of extrathymic malignancies in patients with thymoma is significantly higher than in the general population. Non-Hodgkin lymphoma represents the most commonly associated tumor type. We report the concurrence of primary thymic squamous cell carcinoma and disseminated intravascular large B-cell lymphoma (IVL) in a 78-year-old man characterized by a rapidly fatal clinical course. To our knowledge, this is the first time that such an association is reported. Due to its rarity and the multiplicity of presentations, it is very difficult to diagnose this type of extranodal lymphoma antemortem. The intravascular lymphoma should be included in the differential diagnosis when a patient presents signs of a systemic disease and marked elevation of serum LDH. In this case the lymphoma may have been developed as a result of defective immunologic surveillance or impaired immunoregulation caused by the thymic carci-noma. In our case as in some other cases of IVL, diagnosis could only be conclusively confirmed on autopsy.


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