TITLE

Long-Term Suppressive Combined Antiretroviral Treatment Does Not Normalize the Serum Level of Soluble CD14

AUTHOR(S)
Méndez-Lagares, Gema; Romero-Sánchez, M. Concepción; Ruiz-Mateos, Ezequiel; Genebat, Miguel; Ferrando-Martínez, Sara; Muñoz-Fernández, María Á.; Pacheco, Yolanda M.; Leal, Manuel
PUB. DATE
April 2013
SOURCE
Journal of Infectious Diseases;Apr2013, Vol. 207 Issue 8, p1221
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Levels of soluble CD14 (sCD14) were longitudinally measured in 85 human immunodeficiency virus (HIV)–infected subjects during long-term receipt of suppressive combined antiretroviral therapy (cART) and compared to those in young and elderly HIV-negative control subjects. cART did not normalize sCD14 levels; rather, the HIV-infected group displayed a significantly higher sCD14 level at baseline (ie, before cART initiation), 1 year after cART initiation, and 5 years after cART initiation, compared with both control groups. Furthermore, the baseline CD4+ T-cell count was inversely associated with the baseline sCD14 level. Our results point to the necessity of complementary therapies to treat the activated/inflamed status associated with chronic HIV infection and to the benefits of early initiation of cART.
ACCESSION #
86429003

 

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